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Biomedical subjects

J Lange

Publications and source records attributed to J Lange.

At least 127 records · Page 7Linked to original sources
PubMed1990

The effect of substitution on anticonvulsant activity of some 5,5-diphenylhydantoin derivatives.

Some 5,5-diarylhydantoins and their 3-amino derivatives were synthesized as phenytoin analogs with enhanced rotational restriction of the benzene moieties. In preliminary pharmacological tests, the compounds symmetrically substituted in the benzene rings proved practically inactive as anticonvulsants. High and prolonged activity was observed with 3-amino-5,5-diphenylhydantoin.

Animals↗
PubMed1989

Tetracycline and erythromycin distribution in pathological lungs of humans and rat.

Tetracycline and erythromycin concentrate highly in pulmonary tissues in humans as well as in the rat. Their binding to the lung, whatever the species and the pathological state, is weak. Their intrapulmonary concentrations could be explained by a passive diffusion which depends on the pH variation between the intra- and extratissue compartments, the percentage of un-ionized form present, and their liposolubility. The importance of retention of tetracycline and erythromycin by plasma proteins is demonstrated by the decrease of their pulmonary index of penetration (IP, the intra- and extratissue concentrations ratio). The IP values are, respectively, 1.09 and 1.23 for tetracycline and erythromycin. These concentrations are in excess of their minimal inhibitory concentrations for bacteria responsible for pneumopathies. The lung homogenate binding of these antibiotics is weak (5% for erythromycin and 33% for tetracycline), corresponding to a nonsaturable binding to three main subcellular fractions (nucleus, mitochondria, and cytosol). Tetracycline has the same penetration in healthy or cancerous human lungs, whereas erythromycin presents a decreased IP in cancerous tissue. However, the binding of these antibiotics to healthy or cancerous lung homogenates is similar. So, the structure of cancerous cells is solely responsible for this modification of erythromycin penetration. The intrapulmonary concentration of tetracycline is increased in rat lungs infected by Legionella pneumophila. This modification is due to a great bacteria retention. In contrast, erythromycin possesses the same IP in healthy and infected rat lungs.

Animals↗
PubMed1987

[Stomach cancer--the current situation from the surgical viewpoint].

From July 1st 1982 to December 31st 1986, 359 patients with a histologically confirmed gastric carcinoma were operated on. At the beginning of therapy, 44.3% were in the pathological anatomical stages I and II, 55.7% in stages III and IV (UICC 1987). 307 patients could be resected (resection rate 85.5%). The proportion of R0 resections (no residual tumor) was 61.9%, R1 resections (microscopically demonstrable tumor residues) 23.1% and R2 resections (macroscopical tumor residues) 15%. Overall, a curative resection could be carried out in 61.9% of the cases and a palliative resection in 38.1% of the cases. In 21.5%, a subtotal gastric resection, in 48.2% a total gastrectomy and in 30.3% an extended total gastrectomy was necessary in addition. The lethality was 3.0% for subtotal resection, 5.4% for the simple total gastrectomy and 9.6% for the extended total gastrectomy. The prognosis corresponds to the tumor stage at the beginning of therapy (three year actuarial survival: stage I 76%, stage II and III 26%, stage IV 7%).

Gastrectomy↗
PubMed1987

[Lymphadenectomy: indications--technic--invasion--documentation].

From July 1st, 1982 until December 31st, 1986 359 patients were operated on carcinoma of the stomach. On an average 27.1 +/- 7.2 lymphnodes were removed and of these 9.8 +/- 6.1 lymphnodes were positive. The number of lymphnodes may be increased up to 42.2 +/- 8.8 by extended gastrectomy + splenectomy + left resection of the pancreas, that means by clearing out compartment III. It seems that radical lymphadenectomy of compartment I and II improves prognosis for stage N 1 by adjusting the median survival time to stage N 0.

Gastrectomy↗
PubMed1987

Alterations of beta-adrenergic, muscarinic cholinergic receptors and imipramine binding sites in human lung tumors.

Direct ligand binding techniques have been used to compare beta-adrenergic receptors, muscarinic cholinergic receptors and imipramine binding sites in human tumoral and healthy lungs removed from eleven patients during operations. Beta-adrenergic and muscarinic cholinergic receptors are present in tumoral tissues but their concentrations were decreased compared to healthy tissues. Imipramine binding sites were absent. It is concluded that this type of studies could bring additional information to morbid anatomy analysis and be used to follow illness evolution.

Adenocarcinoma↗
PubMed1987

Escape of hybridomas from cellular defense mechanisms: an in vitro study using autologous and allogeneic lymphocytes.

This study revealed that a hybridoma cell line made from an adenocarcinoma of the colon and autologous enucleated peripheral lymphocytes shared antigenicity of the fusion partners. The hybrid cells could be grown in BALB c nu/nu mice, forming a solid tumor. Gating out hybridoma cells with both CEA and T3 antigens by means of cytofluorometer cell sorting and using them as target cells in a cytotoxicity assay against autologous and allogeneic lymphocytes, the susceptibility for cell-mediated lysis within the cultured hybridoma cells was already lost. These findings suggest that transferred membrane component(s) (T3 antigen) from enucleated lymphocytes are candidates for functional regulator(s) in cell-mediated lysis.

Adenocarcinoma↗
PubMed1986

A differential sex effect of amphetamine on exploratory behavior in maturing mice.

The effects of amphetamine (5-20 mg/kg) were studied 60 min after injection in mice aged 2, 3, 4 and 6 weeks postpartum. Exploratory behavior as indicated by the "head poke" test was depressed at all ages, but appeared to be relatively uncomplicated by other effects at the 5 mg/kg dose. At 4 and 6 weeks control females showed significantly greater activity than males, and amphetamine produced a greater reduction for control levels than in males.

Age Factors↗
PubMed1986

Cerebral resuscitation after cardiac arrest using hetastarch hemodilution, hyperbaric oxygenation and magnesium ion.

This study was done to investigate the effects of hemodilution, hyperbaric oxygenation, and magnesium sulfate on cerebral resuscitation. Sixteen mongrel dogs were anesthetized, and monitored via pulmonary artery catheter, arterial catheter and electrocardiogram. A left lateral thoracotomy was done. Ventricular fibrillation was obtained by application of a 6-volt AC current. Mechanical ventilation was stopped. Total arrest time was 12 min. All dogs were cardiac resuscitated within 6 min using internal massage, ventilation, bicarbonate, epinephrine and internal defibrillation. The animals were then randomized into three groups. Group I represented controls, and were not treated. Group II dogs received normvolemic hemodilution using hetastarch (Hespan) containing magnesium sulfate (2000 mg/l), resulting in a hematocrit of 20%-30%. Group III dogs received the above hemodilution plus compression in a hyperbaric oxygen chamber to 2 atmospheres absolute. Critical care management and hourly neurologic scoring was performed for 7 days by blinded observers. All dogs at the time of death underwent autopsies for gross study. Data analysis revealed no statistical difference among the three groups with respect to survival time, cardiac function or neurologic scoring.

Analysis of Variance↗