Biomedical subjects
Publications and source records attributed to J Lang.
The postnatal increase of the paramedian distances of the medial and lateral plate of the pterygoid process, its elongation and also the position of the plates to the median sagittal plane were investigated. Moreover the development of height and width of the pyramidal process and the scaphoid fossa were surveyed.
The ventricular antifibrillatory effects of two calcium channel blocking agents have been studied by determining fibrillation threshold several times in the course of an experiment on dogs placed under total cardiopulmonary by-pass to avoid the impairment of the myocardium properties subsequent to the interruption of blood circulation. These drugs were used in therapeutic or even higher doses (verapamil 0.40 mg.kg-1, diltiazem 0.60 mg.kg-1). They failed to modify fibrillation threshold significantly, and did not influence fibrillation rate or the effective refractory period of contractile fibres. Lidocaine, on the contrary, under the same experimental conditions, induced a dose-dependent rise in fibrillation threshold of up to nearly 200%, correlated to a fall in fibrillation rate and a prolongation in effective refractory period.
Occurrence, width and course of the radicular arteries and veins between the occiput and L3 level of the spinal cord were described. The diameter of the anterior spinal, posterior spinal, and posterolateral arteries, was also measured on the segments C2 to C6 and T2 to T10, and L2. Likewise the anterior and posterior spinal veins and the anterolateral and posterolateral veins were determined.
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The course of the fila radicularia in the caudal part of the dural sack is described (Diagram 1, Fig. 1), also the length of the dorsal fila is estimated (f.e. L5 = 138,6 mm), the height of the segments (f.e. S3 = 5,41, S4 = 3,88 mm), the length of the vaginae radiculares (f.e. L5 = 24,6 mm), its angle with the side border of the dural sack (f.e. L5 = 142 degrees) and the distances between the vaginae radiculares (f.e. L4-L5 = 26,67 (21-33) mm). The filum terminale of the spinal cord has a length of 153 (123-178) mm, the filum of the dural sack is 67,8 (48-92) mm long.
The above mentioned portals and channels of the skull were measured at 98 skulls of infants with variable stages of life and discussed with the results of former investigators. Length, width, angles and distances to different points of the skull base and the median sagittal plane were measured.
Course, width, and mouth of the Vv. jugularis externa, jugularis anterior, suprascapularis, transversa colli, vertebralis anterior, and retromandibularis are estimated and the variability of the arcus venosus juguli is included.
Origins, length, and insertion zones of the pectoralis muscles are described. The pocket of the pectoralis major and the square area of these muscles and some variations (Mm. sternales and the muscular arch) are included.
Nuclear DNA is looped by attachment to a matrix or cage. Using nine different lines transformed by polyoma or avian sarcoma virus, we have mapped viral sequences integrated within these loops. In all lines that contain high concentrations of viral transcripts and express the transformed phenotype, the integrated viral genes lie close to the points of attachment to the cage. Integration of polyoma DNA induces outlying cellular sequences to become closely associated with the cage. The strength of this correlation between gene activity and proximity to the cage was examined using sub-clones of one avian sarcoma virus transformant. Proviral sequences are closely associated with the cage in this transformant, much less so in two untransformed 'flat revertants' which contain no detectable viral transcripts but regain their close association with the cage in two retransformed derivatives.
Herpes simplex virus type 1 (HSV-1) induces an immediate-early (IE) polypeptide IE 12. An equivalent polypeptide coded by HSV-2 which migrated slightly more slowly on SDS-polyacrylamide gels was identified and designated IE 12.3. Analysis of the serotype of the IE polypeptide induced by five HSV-1/HSV-2 intertypic recombinants when correlated with their genome structures showed that IE 12/IE 12.3 mapped in the region spanning the TRs/Us junction. Unlike four other IE polypeptides induced by HSV-1 (IEs 175, 110, 68 and 63), IE 12 was not detectably phosphorylated.
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The postnatal growth of the nasal bones, the piriform aperture, the choanae, the anterior and posterior nasal spine, and the floor of the nasal cavity were investigated. The development of weight and width of the nasal cavity as much as some results of the postnatal development of the inferior and medical conchae are connected with out investigations. Moreover the increase of the distance between Nasospinale and the sphenoidal sinus aperture and also the development of height and width of the nasal crista of the palatine bone were determined.
A rare condition of the origin of the lateral occipital artery is described. The artery arises from the internal carotid artery and gives off cortical branches and central branches. From the A. occipitalis medialis origin from the arterial circle, central and cortical branches arises too. The caliber of the branches and the side of origin are discussed with other results from normal brains and our knowledges of the genesis of the cerebral arteries.
The postnatal growth from different structures would be investigated at 61 skulls of children and 87 skulls of adults. The mean distance between the Foramen caecum and the Protuberantia occipitalis interna (internal length of the skull) increases from 9.7 cm to 14.0 cm. The greatest internal width of the skull grows up in the mean from 6.8 cm to 12.9 cm. The mean surface area of the Fossa cranialis media includes 7.6 cm2 by newborns and 22.4 cm2 by adults. The surface area of the right Fossa cranialis media is significantly more extensive than the left one. The mean radius of the curvature of the Ala minor ossis sphenoidalis increases from 11.8 mm to about 26,0 mm. The side angle of the Ala minor ascends from 75.7 degrees to about 84 degrees in a detour way. The bight to be found underneath for the Polus temporalis has a mean surface area of 24 mm2 in the newborns and 64 mm2 in the adults. The deepest zone of the floor of the Fossa cranialis media is to be located in newborns in the mean 2 mm and in adults in the mean 0.4 mm below the Frankfort plane and 6.4 mm dorsal of the Tuberculum articulare. The mean distance to the Processus zygomaticus cornes to 4.5 mm in newborns and 0.9 mm in adults. The Fossa temporalis deepens in all measured zones during the postnatal development. Apart from the right-left-differences the acceleration during the last 150 years and the sexual dimorphismus of the skull will be discussed.
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