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Biomedical subjects

J L Giunta

Publications and source records attributed to J L Giunta.

At least 55 records · Page 3Linked to original sources
PubMed1978

The effect of dinitrochlorobenzene (DNCB) on dimethylbenzathracene (DMBA) carcinogenesis on hamster buccal pouch.

DNCB is an antigen that stimulates the cell-mediated response in a sensitized host. The purpose of this study was to define the effect DNCB would have on a standard model system for oral carcinogenesis, theorizing that tumorgenesis would be delayed or inhibited. Fifty-six Syrian hamsters were divided into four groups. In group A (DNCB/DMBA), the right buccal pouch of twenty animals was treated with 2% DNCB in orabase, twice a week, and 0.5% DMBA, three times a week, for 10 weeks. In group B, twenty animals received DMBA only. In group C, six animals received DMBA in Orabase. In group D, ten animals received DNCB in Orabase only. The animals were killed at 6, 12, 16, and 20 weeks. The results indicate that there were no differences in the latent period or in the histologic characteristics of the epidermoid carcinomas that developed. However, there was sensitization of the buccal pouch in pouches painted with DNCB, in that gross and histologic evidence of a delayed sensitivity reaction was demonstrated.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1977

Radiographic changes of the mandible related to oral contraceptives.

This study tested a hypothesis that some radiopacities on radiographic surveys, specifically in the alveolar bone of the mandible from first molar to first molar, not related to the teeth by position or by pathosis, were related to the taking of oral contraceptives. The random sample included 218 adults entering consecutively for full-mouth radiographic surveys at the Radiology Department. All female patients were asked pertinent questions regarding their use of oral contraceptives. Those not responding (fourteen) were not included in the final tabulations. Radiographs were viewed without regard to sex by two persons at the same time, and an interpretation was made concerning the presence (positive) or absence (negative) of the radiopacities in question. Results were based on 204 patients (112 women and 92 men). Positive radiographic findings were significantly more frequent in women (45/112 versus 14/92; chi-square = 14.12; df = 1; p less than 0.001). Positive radiographs were significantly more likely in women using oral contraceptives (28/45 versus 5/67; chi-square = 36.25; df = 1; p less than 0.001).

Adolescent↗
PubMed1976

Keratonodular tonsillitis.

Reported is an unusual lesion on the right palatine tonsil in a man with latent primary syphilis. The lesion was white, nodular, firm, and asymptomatic, and histologically had a keratinized surface; it was not caused by primary syphilis or any other known or described entity. The term keratonodular tonsillitis has been coined to designate this lesion of unknown cause or significance.

Adult↗
PubMed1975

Oral focal acantholytic dyskeratosis (warty dyskeratoma). Report of two cases.

Two cases of intraoral focal acantholytic dyskeratosis are presented. These uncommon, small, nodular, keratotic lesions, with a distinct histologic pattern similar to that of Darier's disease, have been reported as warty dyskeratomas. Treatment is conservative surgical removal and follow-up. It is suggested that the histologic diagnostic term of focal acantholytic dyskeratosis be used, since there may be several clinical entities with a similar histology but different etiology.

Acantholysis↗
PubMed1975

Congenital granular-cell tumor of alveolar ridge and tongue. Report of two cases.

Granular-cell tumors in the oral cavity occur primarily on the tongue (myoblastoma) in adults and on the gum pads (congenital epulis) in infants. Because of the usual location and age, these histologically and histochemically similar tumors have been separate clinical entities. These case reports, however, report the concurrence of both clinical entities in the same patient. A 7-day-old female infant had a 1 cm. epulis on the right anterior maxilla and two 1.5 mm. masses on the anterior ventrum of the tongue. A 12-day-old girl had a 1 cm. epulis on the anterior mandible and two 1.5 mm. masses on the anterior tongue near the tip. In both cases, all lesions were histologically and histochemically similar and were granular-cell tumors. This suggests a relationship in the origin of these entities and tends to rule out an odontogenic origin for the epulis.

Female↗
PubMed1975

The staphylococcal scalded-skin syndrome versus erythema multiforme.

This article reports a case of scalded-skin syndrome in a young child. Characterized by a generalized exfoliative dermatitis resembling scalded skin, the disease may involve the oral mucosa and must be differentiated from Stevens-Johnson syndrome (erythema multiforme). Since the etiology is specific, the disease can be treated with antibiotics with dramatic results.

Administration, Oral↗
PubMed1975

Raynaud disease with oral manifestations.

A young women with a history of Raynaud phenomenon, without underlying disease, manifested spasms of the tongue at times when the episodes of the hands were most severe. Striking changes in the appearance of the tongue occurred.

Adult↗
PubMedDate not supplied

Nasolabial condylomata lata: report of case.

The clinical manifestations of secondary syphilis are many and varied. Thus the venereologist frequently does not see the common textbook picture of this stage of syphilis. The present history of an atypical case of secondary syphilis illustrates one of the many manifestations of syphilis.

Adult↗
PubMedDate not supplied

Relationships among education, dentate status, and diet in adults.

The Nutrition and Oral Health Study (NOHS) was established to study the interrelationship of oral health status, dietary intake, and education, and to define their relative impact on the middle aged and elderly. Two hundred forty-seven partially or fully dentate (at least 6 teeth) subjects returned two food diaries over a 16-month period. Despite the investigators' efforts to enroll from a socio-economically diverse Boston population, the volunteers were health-conscious, with 85% having been to the dentist within the last year; 95% brushed, and 60% flossed daily. More than half the volunteers had attended college. With the exception of cholesterol intake, which was high in both the higher- and lower-educated males, most individuals, despite their dentate status, sought good nutrition. People who wore dentures consumed more refined carbohydrates and sucrose. As the number of teeth declined, Vitamin A, crude fiber, and calcium declined, while cholesterol rose. These factors may have a significant implication for general health.

Adult↗