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Biomedical subjects

J L Giunta

Publications and source records attributed to J L Giunta.

At least 37 records · Page 2Linked to original sources
PubMed1985

Studies on the vascular drainage system of the hamster buccal pouch.

Because some investigators feel that the hamster buccal pouch is an immune privileged site with no lymphatic drainage, this study was done to demonstrate and further elucidate a drainage system from the pouch to the cervical nodes. Eight hamsters were injected with india ink, submucosally in the right pouch. Dissections at one or 2 days revealed ink in macrophages in the right submandibular nodes at 2 days. Histologically, the ink was noted within macrophages which aggregated around blood vessels. No lymph vessels were noted in the pouch. Six hamsters were injected with fluorochrome-labelled latex microspheres. At 2 and at 4 days the microspheres were noted in both the pouches and the ipsilateral submandibular nodes. The results indicate there is a delayed lymphatic drainage from cheek pouches to the submandibular nodes mediated by macrophages.

Animals↗
PubMed1984

Swelling of the neck caused by the submandibular gland on swallowing.

Swellings of the neck are important to note. They may represent inflammations, primary tumors, or metastatic disease. Sometimes, however, there are normal structures that present as swellings and mimic disease. This is an account, with explanation, of a unilateral swelling in the neck that was caused by a normal submandibular gland with aberrant movement.

Adult↗
PubMed1984

Ampicillin allergy presenting as secondary syphilis.

This article reports a case of ampicillin rash with oral and skin lesions, including lesions on the palms and the soles. The distribution of the lesions in a young, sexually active man was suggestive of secondary syphilis. The history, the nature of the delayed rash of ampicillin, and the treatment are reviewed.

Adult↗
PubMed1983

Dental erosion resulting from chewable vitamin C tablets.

A patient had severe dental erosion that was attributed primarily to the daily chewing of vitamin C tablets for three years. Tests were done to demonstrate the acidity of vitamin C tablets and the demineralization of enamel by a solution made with a tablet. The causes for dental erosion and the varying patterns of erosion are reviewed.

Adult↗
PubMed1983

Squamous odontogenic tumor. A lesion of the periodontium.

The squamous odontogenic tumor (SOT) is a benign lesion of the periodontium most probably arising from the rests of Malassez. Most lesions are solitary tumors but multiple lesions may occur. There is equal distribution in the jaws with the posterior mandible and anterior maxilla, the most common sites. The majority of patients are under age 32 and there is no sex predilection. Radiographically the usual appearance is a triangular or semicircular radiolucency of alveolar bone with sclerotic and/or scalloped margins. Clinical findings include sensitivity of teeth, mobility and movement of teeth and deep pocket formation. The maxillary lesions tend to be more aggressive than those of the mandible, and extensive resection may be required. In most cases, however, conservative surgery appears adequate. The histopathologic findings are now clearly delineated so that the SOT should not be confused with ameloblastoma or epidermoid carcinoma.

Adult↗
PubMed1982

Dermoid cyst of the tongue with sinus tract.

This article reports a rare case of a dermoid cyst of the body of the tongue in a 5-year-old child. A small nodule in the midline of the dorsum of the tongue had been present since birth. Surgically removed, the lesion was of a sinus tract that was apparently also present since birth. It was connected to the cyst within the musculature of the tongue. There has been no recurrence.

Child, Preschool↗
PubMed1981

The effect of 13-cis-retinoic acid on hamster buccal pouch carcinogenesis.

In order to determine whether 13-cis-retinoic acid, an analog of vitamin A, has antitumor activity in an oral cancer model system, the following study was undertaken. Fifty-three adult hamsters were divided into four groups. Group 1 was tested with a 0.5 percent solution of 9,10-dimethyl-1,2-benzanthracene (DMBA) in heavy mineral oil, which was painted on the right buccal pouch three times per week for 12 weeks. Group 2 received DMBA plus 13-cis-retinoic acid (RA) incorporated into gelatinized beadlets and mixed with a powdered commercial diet (dosage, 300 mg per kilogram of diet). Group 3 received only RA; Group 4 received a placebo. The animals were killed at 6, 12, and 18 weeks and tissues were studied clinically and histologically in a routine manner. Results show that all groups receiving DMBA developed epidermoid carcinomas. However, there were several other changes. In the RA-treated animals, particularly those treated with DMBA, there was an ingrowth of surface epithelium with development of ductal structures in the buccal pouch. There were changes in surface epithelium, and there were dense aggregates of lymphoid tissue with development of exophytic nodules suggestive of lymphoma. Animals fed RA showed a relative weight loss. The findings suggest that there was a hypervitaminosis A state yielding prominent epithelial metaplastic changes but not affecting the progression or production of carcinoma.

9,10-Dimethyl-1,2-benzanthracene↗