Biomedical subjects
J L Federman
Publications and source records attributed to J L Federman.
Ischaemia and neovascularization.
Varied clinical situations associated with ocular neovascularization are described and categorized according to whether they are initially venous, capillary, or arterial obstructive in origin. Common to many of these entities is the presence of retinal ischaemia, as evidenced by retinal capillary non-perfusion with intravenous fluorescein angiography. The similarities between an experimental angiogenesis model and clinical vasoproliferative disease states are also noted.
Tumor-associated antibodies in the serum of patients with ocular melanoma. II. Variation in antibody level after xenon arc photocoagulation.
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Tumor-associated antibodies in the serum of patients with ocular melanoma. III. Immunoperoxidase detection.
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Vitreous inhibition of tumor neovascularization.
Cartilage has been reported to contain a factor that inhibits tumor neovascularization. Rabbit vitreous, another avascular tissue, has also been shown recently to have an inhibitory effect on tumor neovascularization. This report describes our results on the effects of bovine and human vitreous on tumor neovascularization with use of a rabbit cornea model. Inhibition of neovascularization was observed with both bovine and human vitreous in the form of reduced new blood vessel growth over and around the vitreous pellet and subsequent delayed exophytic tumor growth. Stimulation of neovascularization by bovine and human vitreous was also observed as an early, short-lived response.
An objective analysis of proliferative diabetic retinopathy before and after pars plana vitrectomy.
Nineteen eyes on which pars plana vitrectomy was performed were studied with fluorescein angiography. The degree of background diabetic retinopathy before and after surgical treatment appeared unchanged. The degree of proliferative retinopathy not only was less after surgical treatment, but continued to show regression with time.
An alternative method of gas-fluid exchange through the limbus in giant tears and other complicated retinal detachments.
An alternative method of gas-fluid exchange through the limbus in patients with giant tears and complicated retinal detachments is presented. The indications for the combined surgery of scleral buckle, vitrectomy, and gas-fluid exchange are suggested. The results of this type of surgery in 5 patients with giatn retinal tears, and in 12 patients with complicated retinal detachments, are reported. Most failures were caused by massive periretinal proliferation.
Varix of the optic disk.
A 74-year-old woman had a saccular dilatation, presumably of the central retinal vein, on the optic nerve head. The lesion caused no symptoms, and over a four-month period showed (vidence of thrombosis and stagnation within it. The lesion caused no interference with either the arterial or venous circulation of the retina. We advised no treatment and continue to observe the patient.
Retinitis secondary to acquired systemic toxoplasmosis with isolation of the parasite.
A 43-year-old woman developed a heterophile-negative infectious mononucleosis syndrome for which no cause was apparent. During her illness she developed subjective changes in the central vision of her right eye and had focal retinal inflammation, which suggested the diagnosis of toxoplasmosis. The clinical course was accompanied by an increased titer to Toxoplasma gondii. Organisms were isolated from lymph node tissue and injected into the peritoneum of mice from which organisms were harvested.
Effect of local treatment on antibody levels in malignant melanoma of the choroid.
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Fluorescein angiography of the uvea.
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Intraocular microsurgery: I. New instrumentation (SITE).
The SITE instrument appears to combine advantages of other instruments previously described. It meets the proposed objectives of an efficient cutter where tissue is removed at the front end of the tip. It allows the surgeon complete control of the suction and reflux systems. The instrument is of a simple modular dsign. A fiber optic attachment is available. It is dependable and safe.
Angioid streaks. II. Fluorescein angiographic features.
Fluorescein angiographic sequences from 31 patients with angioid streaks were evaluated. In contrast to previous reports, the streaks usually showed an early central zone of hypofluorescence. We postulated that the hypofluorescence was due to a break in Bruch membrane, causing a separation of the choriocapillaris. This resulted in an area of nonperfusion. Adjacent light-colored areas were hyperfluorescent, possibly due to abnormal retinal pigment epithelium, thickened Bruch membrane, and patent choriocapillaris. The hypofluorescence of the paired red-brown spots may have resulted from an increased pigment density. The intermittent hypofluorescent spots comprising the area of peau d'orange were thought due to focal dehiscences in Bruch membrane and the choriocapillaris. The hyperfluorescent isolated focal lesions may have resulted from an abnormal thickening of Bruch membrane and a patent choriocapillaris.
Angioid streaks. I. Ophthalmoscopic variations and diagnostic problems.
Fifty-six patients with angioid streaks were evaluated ophthalmologically. Most had repeated fundus photography and fluorescein angiography during a follow-up period of 6 months to 7 years. The ophthalmoscopic variations and diagnostic difficulties which occurred were noted. In most instances, the angioid streaks were not initially recognized and the patient was referred with another diagnosis. In several cases, the peripapillary, macular, and peripheral changes seen with angioid streaks were found to simulate other better known fundus conditions, resulting in the erroneous diagnosis and improper treatment. In some cases, the angioid streaks were so subtle that they were overlooked and in others they were observed, but initially interpreted as something else. Because of the medical significance of angioid streaks, ophthalmologists should be aware of their variable features. These are discussed, with emphasis upon those subtleties which differentiate angioid streaks from other conditions which they may simulate. On the basis of these observations, an ophthalmoscopic differential diagnosis of angioid streaks is proposed.
Tumor-associated antibodies to ocular and cutaneous malignant melanomas: negative interaction with normal choroidal melanocytes.
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The retinal vasculature of the Chinese hamster: a preliminary study.
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The significance of the 32-P uptake test in the diagnosis of posterior uveal melanomas.
One hundred consecutive histologically confirmed malignant melanomas of the posterior uvea; on which the 32-P test was performed prior to enucleation, were classified according to cell type. The 32-P uptake results of the pure spindle cell melanomas were compared with the results in the mixed and epithelioid cell tumors. There appears to be no relationship between 32-P uptake and cell type using the Callender classification. The 32-P uptake results in the 100 melanomas were then compared with the results in teh 30 benign lesions which are known to simulate melanoma occasionally. There was a significant difference in 32-P uptake between the benign and malignant lesions, and no false-positive results were encountered. The importance of the 32-P test as a diagnostic adjunct for malignant intraocular tumors is emphasized.