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Biomedical subjects

J L Federman

Publications and source records attributed to J L Federman.

At least 37 records · Page 2Linked to original sources
PubMed1984

Automated static perimetry to evaluate diabetic retinopathy.

The Octopus automated static perimeter was used to evaluate patients with early diabetic retinopathy. It showed islands of threshold sensitivity depression that were equal to areas of nonperfusion seen on fluorescein angiography. The geographic area of the fundus at risk of developing these field defects was found to be between 20 and 45 degrees, representing the central area of the midperiphery. This procedure has potential as an excellent screening test for early diabetic retinopathy.

Adult↗
PubMed1983

Cover slip lens.

Explore the source record for details and available documents.

Cornea↗
PubMed1983

Subretinal cellular bands.

Subretinal cellular proliferation manifests itself in such a way that, with newer techniques in microsurgery, this previously often untreatable condition can be managed. Study of the ultrastructural components of the band suggests that it originates from pigment epithelium.

Aged↗
PubMed1982

In vitro characteristics of uveal malignant melanomas.

During a 17-month period, 33 histologically proved posterior uveal melanomas were prepared for in vitro cultivation in our laboratory. Nine of these remained in culture from five to 12 passages. Four tumors histologically classified as heavily pigmented spindle B cell type remained as pigmented spindle cell tumors in primary culture. During subcultivation one culture lost pigmentation and exhibited mixed cells. Three other tumors, classified histologically as lightly pigmented spindle B cell type, appeared as amelanotic mixed cells in primary culture and grew as epithelioid cells during subcultivation. Two tumors classified as mixed cell type grew as spindle cells in primary culture. One of these last cultures reverted to mixed cell type on subcultivation. One cell culture has shown pigmentary and morphologic changes with variations in carbon dioxide level and media composition.

Culture Techniques↗
PubMed1982

The microsurgical management of giant retinal tears with trans-scleral retinal sutures.

Eight cases of retinal detachment from giant tears were followed from four months to two years. Patients were treated with a combined procedure, including pars plana vitrectomy, rotation of the patient with air-gas fluid exchange to bring the retina into its normal anatomic position, and trans-scleral retinal sutures, using an external rather than internal approach. Seven of the eight cases were reattached successfully. Methods, materials, and complications are described. Pre- and post-operative information regarding visual acuity and results are listed in tabular form.

Adolescent↗
PubMed1982

Management of intraretinal foreign bodies.

Closed posterior intraocular microsurgery with vitreous instruments and bimanual surgical techniques have markedly altered the management of intraocular foreign bodies (IOFB). This paper presents an approach to 14 metallic intraretinal foreign bodies (IRFB) that could not be removed by conventional methods. In all cases, posterior vitrectomy was required to visualize the foreign body or to facilitate its removal through a pars plana incision with intraocular forceps under microscopic visualization. Although successful removal of the intraretinal foreign body was possible in all 14 patients, central visual acuity of 20/400 or better was obtainable in only 40% of this series. An important observation in these patients was a tendency to macular pucker from subsequent epiretinal membrane formation and retinal detachment with massive periretinal proliferation (MPP), which occurred in 90% of these eyes. Despite an obviously enhanced ability to remove foreign bodies from the retina, made possible by vitreous instruments and surgical techniques, the magnitude of the secondary complications in this variety of ocular trauma suggests a poor visual prognosis for such injuries.

Adolescent↗
PubMed1982

Arterial obstruction and ocular neovascularization.

A series of 12 patients (13 eyes) with neovascular glaucoma in association with arterial obstructive disease is presented. Appropriately characterized as having an ocular ischemic syndrome, the anterior segment findings in each included aqueous flare and rubeosis iridis. Posterior segment manifestations included midperipheral intraretinal hemorrhages (venous stasis retinopathy), narrowed retinal arteries, often a cherry red spot, and neovascularization of the disc and/or retina. Most eyes with the ocular ischemic syndrome have either ipsilateral common carotid artery obstruction or severe bilateral obstruction of the internal carotid arteries.

Aged↗
PubMed1982

The surgical and nonsurgical management of persistent hyperplastic primary vitreous.

Fifteen patients (16 eyes) with persistent hyperplastic primary vitreous (PHPV) were followed from one to four years. All but one of the nine eyes in the nonsurgical group showed progressive deterioration. A closed intraocular microsurgical (CIOM) approach posterior to the limbus was used in seven eyes. Three intraoperative complications involving the retina occurred because the retina in these cases inserted directly into the pars plicata and due to the presence of a thick, well-formed vitreous gel. Anterior placement of incisions is recommended to avoid intraoperative complications in small eyes. Early CIOM management is suggested in selected cases of PHPV to prevent progressive deterioration leading to phthisis and to afford reasonable cosmetic improvements.

Eye Diseases↗
PubMed1981

Antibody to Toxocara canis in the aqueous humor.

The aqueous humor and serum samples of patients with presumed ocular toxocariasis were examined by an enzyme-linked immunosorbent assay (ELISA) for antibody to the embryonated egg antigen. Using a single dilution (1:8), higher amounts of antibody have been found in the aqueous humor than in the serum samples. Antibody was not found in the serum or aqueous humor of patients with retinoblastoma, Coats' disease, uveal malignant melanoma, or central retinal artery obstruction. While two patients with presumed ocular toxocariasis had normal serum levels of antibody, the aqueous humor ELISA titers were greatly elevated, supporting the clinical diagnosis and suggesting localized antibody production.

Adult↗
PubMed1980

Tritiated fluorescein binding to normal human plasma proteins.

Aliquots of normal human plasma that had been incubated with tritiated fluorescein were examined for radioactive binding to proteins. Samples were fractionated by polyacrylamide gel electrophoresis (PAGE) and gel filtration. Aliquots removed between zero time and two hours showed no specific radioactive binding peaks by either method. Tritiated fluorescein ran well ahead of all proteins at all times on PAGE and well after the protein eluted from a fractionating column (Sephadex G-75). Ten minutes after intravenous injections, PAGE of plasma from three patients undergoing fluorescein angiography with nonradioactive dye showed the only fluorescent band migrating ahead of all protein bands. These methods failed to demonstrate specific binding of tritiated fluorescein to normal human plasma proteins. We conclude that during angiography, fluorescein exists in plasma as an unbound molecule or is so weakly associated with plasma proteins as to be undetectable by the methods used.

Blood Proteins↗
PubMed1980

Experimental ocular angiogenesis.

In 29 experiments, vascular autologous retina from the contralateral rabbit eye was implanted into corneal pockets in New Zealand white rabbits. The implants induced a neovascular growth of limbal vessels that anastomosed with the vessels of the implant in 15 of the cases. Implantation of vascular autologous iris, choroid, optic nerve extraocular muscle, and conjunctiva also induced neovascularization. Avascular peripheral retina, cornea, and scleral implants did not cause a neovascular response, nor did boiled vascular retina, boiled iris, and boiled choroid. Neovascularization from the retinal and iris intracorneal implants was induced by V2 carcinoma.

Animals↗
PubMed1980

Vitrectomy and cystoid macular edema.

Twenty-two patients who underwent vitrectomy surgery for chronic cystoid macular edema (CME) were evaluated. These patients all had uneventful intracapsular cataract extraction, but CME with vitreous adhesions to the cataract incision later developed. Vitrectomy was performed to remove the vitreous from the anterior segment structures in each case. Nineteen of the 22 patients showed improved visual acuities within six months, and all but two had complete resolutions of the CME by one year. These two patients did show marked improvements of visual acuity. The majority of patients younger than 65 years of age had final visual acuities of 20/50 or better, whereas the majority of those older than 65 years had less than 20/50. The results were not influenced by the duration or the pattern of the CME prior to vitrectomy. A prospective study to determine the value of vitrectomy in this type of patient is suggested.

Aged↗
PubMed1980

Tumor-associated antibodies in the serum of patients with ocular melanoma. IV. Correction for smooth muscle antibodies.

Serum samples from patients with choroidal malignant melanoma, carcinoma metastatic to the choroid and "normal" controls containing tumor-associated antibodies (TAA) to tissue cultured melanoma cells were examined for the presence of smooth muscle antibody (SMA). Sera found to contain SMA were absorbed with actin or thrombosthenin and reassayed for TAA. With this modification, 72% (78% before absorption) of patients with uveal melanoma, 26% (78% before absorption) of patients with carcinoma metastatic to the choroid and 13% (24% before absorption) of "normal" controls were found to have tumor-associated antibodies in their serum.

Actins↗