Search PubMed⌕ Search

Biomedical subjects

J Kulczycki

Publications and source records attributed to J Kulczycki.

At least 55 records · Page 3Linked to original sources
PubMed1989

Immunoglobulin G subclass antibodies to measles virus in patients with subacute sclerosing panencephalitis or multiple sclerosis.

Mouse monoclonal antibodies specific for human immunoglobulin G (IgG) subclasses and a sensitive immunoassay were used to evaluate the IgG subclass antibody response to measles virus antigens in cerebrospinal fluid and serum samples from 20 patients with subacute sclerosing panencephalitis (SSPE), 12 patients with multiple sclerosis (MS), and 11 controls with high measles virus antibody titers in serum. In patients with SSPE, measles virus-specific antibodies were found mainly in the IgG1 subclass and the IgG subclass distribution remained unchanged, irrespective of the clinical stage or duration of the disease. In patients with MS and in controls, measles virus activity was also associated mainly with IgG1. However, the activity was significantly lower than that found in patients with SSPE. The results suggest that there is no primary abnormality in humoral immune response to measles virus in patients with MS. The disproportionately high levels of the measles virus-specific IgG1 subclass found in patients with SSPE may be due to persistent antigenic stimulation or reflect a defect in immunoregulatory mechanisms in response to viral infection.

Adolescent↗
PubMed1989

[Degenerative changes in the cerebellum in adult non-lymphoblastic leukemia].

Neuropathological investigations have been performed on 61 patients of both sexes, aged 17-60 years, deceased owing to nonlymphoblastic leukemias. The cerebellar degenerative changes appeared in 51 percent of cases mainly in the grey matter. Distinct rarefaction or atrophy of the cerebellar granular layer and the dentate nuclei were frequent phenomena. The following classification of the cerebellar granular layer damage was used: I degrees - focal rarefaction, II degrees - diffuse distinct rarefaction, III degrees - focal atrophy, IV degrees - diffuse atrophy. The investigations suggest that polychemotherapy is one of the causes of cerebellar degenerative changes, especially atrophy of the granular layer and dentate nuclei, as well as demyelination. In leukemias of short duration more frequently than in the remaining cases lymphocytic perivenous infiltrations appeared in the white matter. It seems to be a consequence of immunopathological reactions between the neoplasm and the nervous tissue in cases with more dynamic course of the disease.

Adolescent↗
PubMed1989

[Clinical diagnosis of Jakob-Creutzfeldt syndrome--analysis of 6 cases].

The authors present an analysis of the clinical course of 6 cases of Creutzfeldt-Jakob disease (patients were aged from 27 to 59 years). The diagnosis was established during the life of the patients. In the neurological status dementia and syndromes of pyramidal and extrapyramidal lesions predominated. Neuropathological examinations in 5 cases demonstrated also considerable cerebellar damage, however, clinical signs of this damage were noted in two patients only. EEG findings were of greatest importance among the laboratory investigations.

Adult↗
PubMed1988

Abolished phosphaturic response to parathormone in adult patients with Fahr disease and its restoration after propranolol administration.

The similar localization of intracranial calcification in hypoparathyroidism and in Fahr disease without parathyroid gland disorder suggests that in these two disorders the pathomechanism of calcium phosphate deposition in the brain may be similar. It may be that in Fahr disease some factors, such as chronic respiratory alkalosis, could lead to hypoparathyroidism-like changes in the brain tissue. Abolition of the phosphaturic response to parathormone (PTH) was recently demonstrated in acute experimental hypocapnia. In three adult patients with Fahr disease, a tendency towards compensatory respiratory alkalosis and arterial hypocapnia was found. The parathormone test revealed a marked decrease in phosphaturia response to PTH, but normal cAMP response. In one patient, the parathormone test was repeated during propranolol administration and showed a considerable improvement in the phosphaturic response to parathormone. It is postulated that chronic hyperventilation and hypocapnia as well as phosphaturic resistance to PTH, intracellular increase of phosphate concentration and development of hypoparathyroidism-like intracranial calcification in patients with Fahr disease could all be caused by disturbance of adrenergic receptors and their relationship to PTH receptors.

Adult↗
PubMed1988

[Not Available].

Explore the source record for details and available documents.

History, Ancient↗
PubMed1984

[Clinical and cisternographic differential diagnosis between presenile dementia and Hakim syndrome].

The authors compared with regard clinical and the radionuclide cisternography examination 27 patients with Hakim-Syndrome and 11 with Alzheimer-Disease. In all cases, dementia was a stable symptom. Patients with Hakim-Syndrome have an early gait disturbance, ataxia and epileptic seizures. Only in case of patients with Alzheimer-Disease we found aphasia, apraxia and psychotic disorders. 24 hours after the injection radionuclide cisternography showed ventricular retention and absence of parasagital accumulation only in patients with Hakim-Syndrome. Lighter changes (mixed cisternographic pattern) were found in patients with Alzheimer-Disease as well.

Alzheimer Disease↗
PubMed1982

Measles antibodies in the saliva of children with subacute sclerosing panencephalitis.

Using the method of haemagglutination inhibition, the authors determined the levels of measles antibodies in the saliva of 14 children with subacute sclerosing panencephalitis. In 13 of them these antibodies were found in titres from 1:8 to 1:128. In the control groups, comprising 29 children, these antibodies were found in the saliva in only two cases and in low titres. There appears to be a correlation between the levels of these antibodies in the saliva and cerebrospinal fluid in patients with subacute sclerosing panencephalitis.

Adolescent↗
PubMed1982

[Case of Creutzfeldt-Jakob syndrome with involvement of the neostriatum].

The authors describe a case of CJD in a man aged 45 years. The disease began with sluggishness of movements and speech difficulties, followed by development of pyramidal system damage and dementia. EEG findings were normal throughout the whole duration of the disease that is 3.5 years. Neuropathological examination disclosed major neuronal loss, spongy degeneration and astrogliosis in the striatum bilaterally. The cerebral and cerebellar cortex and brain stem showed similar but much less intense changes. This particular topography of the lesions was probably the cause of absent EEG changes.

Basal Ganglia Diseases↗