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Biomedical subjects

J Kruszewski

Publications and source records attributed to J Kruszewski.

71 records · Page 4Linked to original sources
PubMedDate not supplied

[Incidence of antigen expression for HLA antigens A,B,C and DR in patients with atopic diseases in Poland].

Studies of several authors suggest an interdependence of atopic diseases and HLA antigens. Therefore, the authors evaluated an incidence of HLA antigens of classes I and II in patients with atopic disease and healthy individuals. The study involved 127 patients with atopy and 79 healthy blood donors. Anamnesis, results of skin tests and serum levels of allergenic-specific IgE served as the base of atopy diagnosis or exclusion. HLA antigens were assayed with a standard micro-lymphocytotoxic test using two series of standard anti-HLA sera. It enabled to detect 16 locus A-dependent antigens, 25 locus B-dependent and 8 locus C-dependent antigens as well as 8 antigens dependent on locus DR. Only antigen HLA-Bw53 was found more frequently in patients with atopic diseases suggesting its relation to atopy. The results concerning other HLA antigens did not confirm HLA antigens association with atopy suggested by other authors.

HLA Antigens↗
PubMedDate not supplied

Value of the test of spontaneous reduction of nitroblue tetrazolium in diabetes decompensation.

Nitroblue tetrazolium (NBT) test was performed in forty-four diabetic patients of both sexes ranging in age from 15 to 64 years. Some of the patients were tested both before and after diabetes compensation. In cases of decompensated diabetes caused by dietary errors or by inadequate dosage of the antidiabetic drugs, NBT results were within normal range. Significantly higher values were observed in decompensation of diabetes caused by bacterial infection. This observation may be used to detect the real cause of diabetes decompensation.

Adolescent↗
PubMedDate not supplied

[Effect of cetirizine therapy on the rate of adverse reactions to specific desensitization].

An effect of cetirizine--one of antihistaminic agents--on the rate of adverse reactions to the specific desensitization has been evaluated in patients with atopic respiratory diseases. The study included 270 patients desensitized in 1988-1993 for the atopic diseases due to hypersensitivity to grass pollens and Dermatophagoides pteronyssinus. Standard Alvac-P. Pollinex, and Alvac-S HDM vaccines have been used. Occurrence and severity of the adverse reactions noted during 3,368 injections of vaccines have been analysed. Frequency and adverse reactions severity have been compared for two periods--1988-1990 when patients have not been given antihistaminic agent, and 1991-1993--when ceterizine has been administered during the whole period of desensitization. It has been found that simultaneous cetirizine administration decreases frequency and severity of adverse reaction to the used vaccines. Such a procedure may be recommended to patients with advance hypersensitivity given vaccines in out-patient clinics.

Adolescent↗