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Biomedical subjects

J Kruszewski

Publications and source records attributed to J Kruszewski.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Seasonal changes in various immunological parameters in patients with hay fever].

In 25 subjects with pollinosis the following parameters were assessed three times annually (early spring, pollen seasons, autumn): serum IgE levels and allergen specific IgE (asIgE), T lymphocyte subpopulation in peripheral blood. In selected patients allergen specific IgG-4 levels were calculated. All serum parameters were assessed using the FAST enzymatic methods (3M Diagnostic Systems). Lymphocyte subpopulations were assessed using the monoclonal antibodies (Ortho Diagnostic System). During the pollen seasons a statistically significant increase of serum IgE, asIgE and T suppressor cells was found. The CD4/CD8 ratio during this period was decreased, caused by stable level of T helper cells. In the 4 patients the levels of asIgG-4 did not change although the initial levels were elevated.

Adolescent↗
PubMed1983

Reaction to intradermally applied phytohaemagglutinin in asthma patients in relation to corticosteroid therapy.

Phytohaemagglutinin (PHA) skin test (diameter of induration 24 h following intradermal injection of 1.0 microgram purified PHA) was carried out on 23 patients with exacerbated atopic asthma and 28 patients with exacerbated non-atopic asthma. Preselected adult patients had either not previously been treated with systemic corticosteroids or steroid therapy had been suspended for at least 3 months. Nearly all non-atopic asthma patients and patients with atopic asthma previously treated with corticosteroids showed increased reactions to PHA. Patients with atopic asthma not earlier treated with corticosteroids demonstrated normal responses. None of the asthmatics showed a negative PHA reaction. Administration of single depot doses of corticosteroids produced decreased reactivity to PHA in nearly all patients. These results suggest that neither atopic nor non-atopic asthma is in itself associated with impaired PHA skin reactivity but that changes in this reactivity are largely due to the corticosteroid therapy administered to these patients. In relation to PHA reactivity certain effects of this therapy may persist for as long as 3 months after its cessation.

Adrenal Cortex Hormones↗
PubMed1983

The comparative evaluation of alpha-2-macroglobulin and immunoglobulin levels in sera of patients with bronchial asthma.

Alpha-2-macroglobulin is the major serum antiprotease capable of inhibiting proteolytic enzymes. Protease-antiprotease homeostasis within the respiratory tract can be altered in bronchial asthma. On the other hand, in their disorder marked changes in immunoglobulin levels are observed and are related to the clinical stage of the disease. Consequently, we hypothesized, that a correlation between the levels of alpha-2-macroglobulin and immunoglobulins might have been existing. In order to evaluate this concept, the comparative analysis of serum alpha-2-macroglobulin and immunoglobulin levels in patients with extrinsic (atopic) and intrinsic (non-atopic) bronchial asthma, and in patients with bronchospastic and emphysema dominated components, was carried out by radial immunodiffusion assays. The positive linear correlation between alpha-2-macroglobulin and IgM levels was observed in patients of all tested groups. These results were discussed in view of the known role of the natural inhibitor of proteolytic enzymes, i.e. alpha-2-macroglobulin, in the protection of asthmatic lung.

Adolescent↗
PubMed1982

Reaction of the human granulocyte system in successfully treated bacterial bronchopneumonia.

The behaviour of peripheral blood granulocyte pools, nitroblue tetrazolium reduction by granulocytes, migration of granulocytes out of skin windows, serum muramidase activity and bone marrow reserve of granulocytes during uncomplicated bronchopneumonia were studied. The time course of changes in these parameters during infection was established, and suggests maximal changes on day 2 of infection with gradual regression until 30 days after the disease onset, when they disappear.

Adult↗