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Biomedical subjects

J Kopolovic

Publications and source records attributed to J Kopolovic.

At least 127 records · Page 7Linked to original sources
PubMed1984

Amputation neuroma of common bile duct with obstructive jaundice: a case report.

A 67-year-old woman was hospitalized because of recurrent attacks of epigastric pain, chills, fever, jaundice and pruritus of 6 months' duration. Six years earlier, the patient had undergone cholecystectomy. The present endoscopic retrograde cholangiopancreatography demonstrated a proximal irregular choledochal stricture. Resection of the stricture with end-to-end anastomosis was performed. Histological examination of the surgical specimen revealed an amputation neuroma.

Aged↗
PubMed1984

Granulomatous prostatitis with vasculitis. A sequel to transurethral prostatic resection.

An 80-year-old patient suffering from prostatism underwent repeated transurethral prostatic resection. Histologic examination of the prostatic tissue that was removed at the time of the second operation disclosed a granuloma with fibrinoid necrosis combined with necrotizing vasculitis. Only four cases of granulomatous prostatitis and vasculitis have been reported in the literature:two were generalized vasculitis, while in the two other instances, the vasculitis was confined to the prostate. We report an additional case of granulomatous prostatitis combined with vasculitis localized in the prostate.

Aged↗
PubMed1983

A case of familial Mediterranean fever with cutaneous vasculitis and immune complex nephritis: light, electron, and immunofluorescent study of renal biopsy.

A 29-year-old patient suffering from familial Mediterranean fever developed severe myalgia and hematuria. Skin biopsy showed vasculitis. The kidney biopsy revealed diffuse proliferative and exudative glomerulonephritis. On immunofluorescent examination, IgM deposits accompanied by C3 were found in coarse granular peripheral distribution. Electron microscopy revealed glomerular subepithelial deposits. Familial Mediterranean fever with vasculitis and immune complex nephritis is discussed.

Adult↗
PubMed1983

Multiple myeloma presenting as dense deposit disease. Light chain nephropathy.

A 45-year-old male was admitted to the hospital because of polyuria and polydipsia. After admission, proteinuria and hematuria were found. The kidney function deteriorated and necessitated the initiation of chronic hemodialysis. Examination of the bone marrow revealed multiple myeloma and kappa light chains were found in the urine. The kidney biopsy showed membranoproliferative glomerulonephritis with dense deposits in the glomerular basement membrane.

Basement Membrane↗
PubMed1980

Second primary lung carcinoma.

Long-term survivors with bronchogenic carcinoma represent only a small fraction of the overall population affected with this disease. Therefore, the occurrence of a second primary lung carcinoma is a rare event and can be diagnosed either simultaneously, or, more frequently, sequentially. A review of the literature disclosed a median interval of five years between metachronous lesions with a range of 0 to 16 years. We thus consider it of interest to report a case in which 17 years had elapsed between the first tumor, successfully treated by a lobectomy, and the diagnosis of a second primary tumor located in the contralateral lung. The literature on second primary lung tumors is reviewed and the histopathological aspects, as well as the therapeutic implications, of this relatively rare condition are discussed.

Aged↗
PubMed1980

Compressed air emboli of the aorta and renal artery in blast injury.

A patient with severe blast injury died shortly after his arrival in the emergency room. A massive compressed air embolism of the aorta was found during exploration of the abdominal cavity in order to use the kidneys for transplantation. The post-mortem findings in the kidney were mainly of multiple air spaces in the interstitium compressing the collecting tubules.

Adult↗
PubMed1978

Development of Hodgkin's disease in a patient with leprosy.

We present a patient with leprosy who developed Hodgkin's disease of the nodular sclerosing type. There are two previous reports describing the combination of leprosy and Hodgkin's disease in a single patient [3, 9]. Hodgkin's disease was diagnosed 14 months after the complete disappearance of mycobacterium leprae from the skin lesions, under treatment with DDS (diamino-diphenyl-sulfone). Hodgkin's disease was treated by irradiation and chemotherapy. Obstructive jaundice developed which resolved under treatment by irradiation of the hilar area of the liver, chemotherapy and hormones. During two years of immuno-suppressive therapy, without DDS, no exacerbation of the leprosy occurred.

Adult↗
PubMedDate not supplied

Relation of preexisting anti-beta2GPI antibodies to infarct size in a rat model.

BACKGROUND: Anti-beta2-glycoprotein I (beta2GPI) antibodies (a subpopulation of antiphospholipid (aPL) antibodies) are associated with a procoagulant state in humans and with enhanced atherosclerosis in experimental animal models. Moreover, the presence of high titers of aPL antibodies in relatively young patients is associated with higher incidence of subsequent myocardial infarction. Herein, we evaluated the role of preexisting high levels of aPL antibodies in determining the size of the infarct induced by permanent ligation of the left anterior descending artery (LAD) in a rat model. METHODS AND RESULTS: A total of 11 Wistar rats were immunized and boosted with 10 microg of the phospholipid binding protein -beta2GPI (a method commonly applied for induction of aPL antibodies). Rats in the control group (n=9) were immunized and boosted with a Freund's adjuvant. Upon development of high anti-beta2GPI antibodies levels, myocardial infarction was induced by ligation of the LAD coronary artery. Rats were sacrificed 7 days later, their lymph nodes were collected for evaluation of cellular immunity to beta2GPI and their hearts were removed for assessment of infarct size and for immunohistochemical stains for iNOS and TGF-beta. beta2GPI-immunized rats exhibited high levels of aPL antibodies (mean optical density of 1.3+/-0.3) as compared with the control group (mean optical density of 0.12+/-0.03; P<.0001). Cellular immunity to beta2GPI was also pronounced as evident by an increased thymidine uptake and by increased interferon gamma secretion by the lymph node cells from beta2GPI-immunized rats. Myocardial infarct size has shown a tendency to be increased in rats induced to develop anti-beta2GPI antibodies (mean size 23+/-9%) as compared with controls (17+/-12%; P<.23). iNOS positive cells in the infarct area of beta2GPI-immunized rats were significantly increased in comparison to the control group (P<.01). Similarly, TGF-beta cell expression was significantly increased in the infarct area of the immunized rats in comparison to the control group (22.6+/-5.1 and 7+/-2.1 per 100 mononuclear inflammatory cells, respectively; P=.01). CONCLUSION: The presence of high levels of aPL antibodies is associated with higher expression of iNOS and TGF-beta and may contribute to myocardial damage.

Animals↗
PubMedDate not supplied

Analyses of p53 expression pattern and BRCA mutations in patients with double primary breast and ovarian cancer.

OBJECTIVE: To analyze the somatic pattern of p53 expression and BRCA germline mutation status in Israeli patients with both ovarian (OvCa) and breast cancer (BrCa). METHODS: The study group comprised 43 Israeli patients with OvCa, all of whom had previous primary BrCa. p53 immunohistochemistry (IHC) on all available archival tissues and genotyping for the three predominant Jewish germline BRCA1-2 mutations were carried out. Samples from 64 patients with solitary OvCa and 61 with solitary BrCa were similarly analyzed as controls. RESULTS: p53 expression pattern and the immunopositivity rate were similar in the ovarian and breast tumors within the study group and in the two control groups: positive p53 staining was detected in 68% of ovarian tumors in the study group compared with 71.9% in the controls, and in 19.4% of the BrCa tissues versus 21.3% in the controls. Within the study group, advanced stage OvCa had a higher rate of p53 expression (84%) compared to early stage disease (38.5%) (P = 0.006). This difference was not apparent in the solitary OvCa control group. OvCa in BRCA1-2 mutation carriers from the study group were more likely to display positive p53 staining (79%), especially in tumors diagnosed before the age of 60 (90%) compared with the OvCa of noncarriers (60%), but this difference was statistically insignificant. The p53 expression rate in BrCa samples from the study group was not associated with BRCA1-2 mutation status. CONCLUSIONS: Positive p53 expression, detected by IHC, in OvCa patients with previous primary BrCa is significantly higher in advanced stage disease in BRCA1-2 mutation carriers. There is a higher positive p53 expression somatically in OvCa in BRCA1-2 carriers in whom OvCa was diagnosed before the age of 60 years, although this trend is not statistically significant. These observations suggest that somatic p53 inactivation may be an important event in ovarian tumorigenesis in this subset of patients.

Aged↗
PubMedDate not supplied

Chondrosarcoma at the skull base.

A rare case of chondrosarcoma at the skull base is presented. Computerized tomography scan was very helpful in delineating the exact extent of the tumor. Chondrosarcoma is a slow growing malignant tumor which metastasizes very late. Usually it is radioresistant, but when surgery is not feasible, irradiation treatment is worth a trial.

Chondrosarcoma↗
PubMedDate not supplied

Functional and morphological alterations following isolated rat stomach irradiation. A model for estimation of radiation injury.

Exposure of the stomach to tumoricidal doses of radiation is associated with functional and morphological changes. The experimental data have been mainly obtained from studies of whole body irradiation of the stomach. We investigated the separate effect of irradiation on the surgically exposed stomach with doses of between 3 and 30 Gy. A dose-dependent decrease in free and total acidity was observed with relatively low doses (5-9 Gy). Serum pepsinogen and serum gastrin levels increased following irradiation with doses ranging from 5 to 15 Gy. Two phases of increased regenerative activity were documented (between the 1st and 3rd weeks and between the 4th and 8th weeks). No radioprotective effect was observed when sucralfate or misoprostol were utilized. Further investigations are mandatory in order to find an effective radioprotector for the irradiated stomach.

Animals↗