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J Kermarec

Publications and source records attributed to J Kermarec.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Primary pulmonary lymphoma].

The authors report 2 cases of primary pulmonary lymphoma. The first case was a 65 year old woman with a diagnosis of lymphocytic lymphoma confirmed by surgical biopsy, after being suspected on the basis of bronchoscopic biopsies and bronchiolo-alveolar aspiration. Twenty one months after the beginning of treatment with chemotherapy and six months after this treatment was completed, the patient was in complete remission. The second patient was a 52 year old man who underwent left inferior lobectomy for a lympho-plasmacytic lymphoma, which was only diagnosed definitively on the operative specimen. The authors discuss the clinical and radiological features and the histological and immunological criteria of primary pulmonary lymphomas (PPL). There are a number of related diseases with varying degrees of malignancy: interstitial lymphocytic pneumonitis (ILP), pseudo-lymphoma, which corresponds to a localised form of ILP, lymphomatoid granulomatosis (LYG) and pulmonary lymphoma, which usually has a lymphocytic or lympho-plasmocytic cell type.

Aged↗
PubMed1984

[Lymphocytic interstitial pneumonia in Gougerot-Sjögren syndrome with scleroderma].

The authors report the case of a 70 year old woman with a 15 year history of the Gougerot-Sjogren syndrome, Raynaud's phenomenon and sclerodactyly. Progressive respiratory symptoms in this case were not due to pulmonary fibrosis secondary to scleroderma but to diffuse interstitial lymphocytic pneumonia (ILP) secondary to the Gougerot-Sjogren syndrome. The authors emphasize the diagnostic value of the significant, permanent lymphocytosis in the aspirate after broncho-alveolar lavage. The differential diagnosis is difficult because the radiological and clinical signs of pulmonary complications of the Gougerot-Sjogren syndrome and of scleroderma are very similar. Reports of the triple association of ILP-Gougerot-Sjogren syndrome-scleroderma are uncommon in the medical literature. However, prospective studies suggest that paraclinical stigmata of the Sjogren syndrome are relatively common in patients with scleroderma. These observations suggest that some patients with clinical "pulmonary fibrosis" may in fact have ILP secondary to slowly progressive Sjogren's syndrome.

Aged↗
PubMed1983

[Osteomedullary pathology in 5 cases of systemic mastocytosis. Pseudomyelomatous forms with dysglobulinemia and benign medullary polyclonal plasmacytosis. Hamazaki-Wesenberg Bodies associated with mast cell granuloma].

The authors describe bone marrow lesions in five cases of mastocytosis, with particular emphasis on the characteristic features of the infiltration of the mast cells, and the associated bone and medullary lesions. The five cases show two features not commonly encountered in the literature: the presence of seric dysglobulinemia with medullary polyclonal plasmacytosis in two cases; and the association of mast cells with Hamazaki-Wesenberg bodies in the other three. After recalling the actual mechanisms of bone lesions secondary to mast cell infiltration, the authors propose an explanation for the non-casual association of mastocytosis and Hamazaki-Wesenberg bodies, which has not been previously reported.

Adult↗
PubMed1982

[Functional interpretation of villous atrophy of the small intestine].

The villosities of the small intestine form a special structure (absorbing enterocytes, functional vascularisation of mucosa), manifestly adapted to the working of the absorption function. As a reciprocal, we propose the hypothesis that the maintenance of villous structures depends on the use of the absorption function and we have classified villous atrophies in three groups, according to their mechanism: by insufficiency of the absorbing enterocytary coating, alteration of the connective tissue and especially of functional vascularisation of mucosa, insufficient absorption (functional regression). Though based on a largely conjectural theoretical conception, this classification corresponds, in fact, to particular aspects of the mucosa as to organization of the connective tissue and especially to maturation of the enterocytary series: it should therefore help pathologists to add to the static appreciation of the hight of villosities and the abondancy of plasmocytes, an appreciation of anatomoclinical syndromes or, at least, of unquestionable lesional mechanism.

Atrophy↗
PubMed1982

[Interpretation of minimal medullary plasmacytoses in monoclonal dysglobulinemias. Importance of the study of osteomedullary biopsies of semi-thin sections and immunologic marking].

A monoclonal gammopathy (M.G.) is usually associated with multiple myeloma or macroglobulinemia. Cases whose follow up have not demonstrated myeloma or lymphoma for several years are called "benign monoclonal gammopathies" (B.M.G.). Numerous criteria were suggested to distinguish multiple myeloma from B.M.G., chiefly an abnormal medullary plasmacytosis. But frequently it is only beyond 15 to 20 % that this plasmacytosis is considered as significative. Some authors have reported the peculiarities of these plasma cells immune labelling with rather conflicting results. We reviewed semi-thin sections of bone marrow biopsies with a low grade plasmacytosis (less than or equal to 10 %) by histological cytological and immunological methods in a group of 39 patients with a M.G. A diagnosis of multiple myeloma or of B.M.G. was made on the initial examination of these biopsies. The 24 cases of multiple myeloma were diagnosed using : --topographical criteria : inhomogenous sharing, nests of plasmocytes exclusively away from the periphery of vessels, --cytological criteria such as frequent cellular immaturity, nuclear immaturity in binucleated cells, bizarre shaped nuclei . . . --immunological criteria obtained by immunofluorescence method : strictly monoclonal labelling of plasma cells or "limit"-monoclonal labelling in 50 % of cases. The latter is less characteristic because of its presence in 25 % of B.M.G. In this prospective study, the initial diagnosis was maintained in 37 out of the 39 cases according to clinical and laboratory data. These results seem to demonstrate the practical value of the proposed criteria.

Aged↗
PubMed1982

[Mediastinal pseudotumor due to atrial hernia caused by a left pericardial defect].

Radiological examination in a young adult revealed the presence of an opacity facing the second left arch of the heart shadow. This finding associated with data from computed tomography suggested a diagnosis of a thymic tumor. Surgical exploration demonstrated a defect in the left pericardium through which there was a rhythmic protrusion of the auricle and fatty tissue. Aplasia of the pericardium is rarely observed, and usually involves its left side. It results from premature atrophy of the left Cuvier's canal, and is associated with cardiac or pulmonary anomalies in half of the cases. Diagnosis should be suggested by the abnormal appearance of the second left arch, very often clinically asymptomatic, and is confirmed when the creation of a pneumothorax produces a simultaneous pneumopericardium. A thoracic scan can visualize the left auricular hernia beyond the mediastinal limits. However, pericardial aplasia must remain a differential diagnosis of pathological opacities in the middle mediastinum.

Adult↗
PubMed1982

[Malignant mediastinal embryoma. A case with pulmonary metastasis. Complete remission after chemotherapy].

Rapid increase in growth of a pulmonary metastasis following incomplete excision of a malignant mediastinal embryoma was treated by multiple chemotherapy combining platinum derivatives, actinomycin B, bleomycin, and vincaleucoblastin. Complete remission was obtained. These extremely rare tumours have a histological appearance close to that of testicular tumours. Until recently, their prognosis was such that therapy appeared to be of no avail, but this has been modified by new chemotherapy schedules including, more particularly, the use of platinum.

Adult↗
PubMed1981

[Cefotaxime in bronchopulmonary infections (author's transl)].

Thirty-nine patients, 17 to 80 years old, were admitted to a pneumology department. The diagnosis was acute serious or severe respiratory tract infection in 25 patients, exacerbation of chronic bronchopulmonary infection in 6, purulent pneumonia in 4, purulent bronchitis in 4. 28 infecting organisms were identified: Gram-positive cocci (Pneumococcus: 6, Streptococcus: 8. Staphylococcus: 1) and 6 Haemophilus influenzae (3 of which were associated with 1 Pneumococcus) 7 Enterobacteria (isolated or associated). Local, biological and systemic tolerance was generally very good in the majority of patients. Cefotaxime at a daily dose of 2 g intramuscularly for 12 days, showed very good efficacy in the treatment of various bacterial infections of the lower respiratory tract. The activity was evident against a variety of organisms in respiratory infections. The in vitro results of the antibiogram which indicated a superiority of cefotaxime in some cases on other antibiotics currently used in these indications were confirmed by the clinical results.

Adolescent↗
PubMed1981

[Late cutaneous porphyria in a child with Down's syndrome (author's transl)].

The authors report the case of a patent form of cutaneous or late porphyria in a 4 1/2 year-old child with a reduced activity of the erythrocyte uroporphyrinogene decarboxylase (URO D). This genetically transmitted disease (the father having the same enzyme defect) only appears after the occurrence of an external factor, usually alcohol and estrogens, rarely acute hepatitis with the presence of HAV antibodies as in this case of Down's syndrome. The same clinical picture may be accompanied by various hepatic lesions and, occasionally, by a deficiency of erythrocyte URO D. This justifies that one distinguish generalized familial forms from sporadic forms with exclusive hepatic involvement.

Child, Preschool↗