Search PubMed⌕ Search

Biomedical subjects

J Kelly

Publications and source records attributed to J Kelly.

At least 469 records · Page 26Linked to original sources
PubMed1969

The oxygen uptake and pulmonary blood flow during resuscitation from asphyxia in foetal and adult sheep.

1. The foetuses of twenty-seven Welsh ewes and eight Clun Forest ewes were delivered by Caesarian section at an approximate gestational age of 140 days, maintaining the umbilical circulation. They were asphyxiated by clamping the umbilical cord, and resuscitated with IPPV. Oxygen consumption, heart rate, and blood pressures were recorded, and in one series of eight, blood flow through the left lung was recorded whilst IPPV was applied to this lung only.2. The hypothesis that oxygen consumption is abnormally low during resuscitation of the new-born from extreme asphyxia because of limited blood flow, was supported.3. Adult ewes were also asphyxiated and in a series of eight a quite different pattern of behaviour was observed, due to very rapid and complete recovery of the circulation.4. Observations on the pulmonary vascular resistance suggest that complete vasomotor paralysis occurs during extreme asphyxia, so that resistance falls to a near-minimum level for unexpanded lung. Expansion of the lung produced a large fall in resistance which appeared to be due to the introduction of gas into the alveolar spaces, lessening the resistance to flow of the capillaries.

Animals↗
PubMedDate not supplied

Touch-screen computerized education for patients with brain injuries.

The use of computer technology for patient education has increased in recent years. This article describes a study that measures the attitudes and perceptions of healthcare professionals and laypeople regarding the effectiveness of a multimedia computer, the Brain Injury Resource Center (BIRC), as an educational tool. The study focused on three major themes: (a) usefulness of the information presented, (b) effectiveness of the multimedia touch-screen computer methodology, and (c) the appropriate time for making this resource available. This prospective study, conducted in an acute care medical center, obtained healthcare professionals' evaluations using a written survey and responses from patients with brain injury and their families during interviews. The findings have yielded excellent ratings as to the ease of understanding and usefulness of the BIRC. By using sight, sound, and touch, such a multimedia learning center has the potential to simplify patient and family education.

Attitude of Health Personnel↗
PubMedDate not supplied

A reduced calorie-high fiber diet retards age-associated decreases in muscarinic receptor sensitivity.

The effects of a reduced calorie-high fiber diet (RCHF) were examined on three cholinergic signal transduction (ST) parameters: (a) oxotremorine enhancement of K(+)-evoked dopamine release and (b) carbachol-stimulated low KM GTPase activity [an indicator of muscarinic receptor (mAChR)-G protein coupling/uncoupling], and (c) [3H]Quinuclidinyl benzilate (QNB) autoradiography. Comparisons were made among: young control (6 months), old normal control, old reduced calorie high fiber [both 24 months)]. The results indicated that old reduced calorie high fiber rats (1900 kcal/kg/day, 2.4%, lipids 2.4%, fiber 28%, carbohydrates 40.7%) as compared to the old normal control rats (3000 kcal/kg/day, 4.8% lipids, 4.2% fiber, carbohydrates 61.5%) showed a retardation of age-related deficits in dopamine release (a above) and GTPase activity (b above). These parameters were 25% higher in the old reduced calorie high fiber rats as compared to old normal controls and did not differ from young controls, even though there was no increase in mAChR concentration in the restricted group. Thus, these results indicate that a reduced calorie high fiber diet as utilized in these experiments was effective in retarding the age-related decrements in two of three signal transduction parameters. They are discussed in terms of the induction of membrane changes (e.g., fluidity) or related decreases in oxidative stress by the restricted diet that may be involved in these signal transduction effects.

Aging↗