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Biomedical subjects

J Kato

Publications and source records attributed to J Kato.

At least 541 records · Page 30Linked to original sources
PubMed1985

Clinicopathologic investigation of ovarian endometriosis: a comparative study of cystic and non-cystic types.

This clinicopathologic study involved 129 patients with ovarian endometriosis. All the lesions from the patients were classified macroscopically into two types being either cystic or non-cystic. The results are as follows. Endometriotic lesions were bilateral in 58 cases and unilateral in 71 cases. The average age of the patients was 38.8 and gravidity 1.8, with 43.1% of them being infertilite. In 12.2, 45.4 and 84.6% of them, irregular menstruation, hypermenorrhea, and dysmenorrhea were recorded, respectively. Regarding complicated lesions, 49 patients had fibroid, 33 uterine adenomyosis, and 13 rectocervical endometriosis. Of the 129 cases, 61.3% were regarded as of the cystic type, 30.2% as of the non-cystic type, and 8.5% as of the cystic/non-cystic type. The average ages were 35.5 and 41.6 years for cystic and non-cystic types, respectively. The incidence of each type of complicated lesion mentioned above was greater in the non-cystic type than that in the cystic type. The pathogenetic investigation suggested that cystic endometriosis in the ovary might mainly be ascribed to the endometrioid metaplasia of the celomic epithelium and that non-cystic endometriosis might occasionally originate from metastasis or implantation of endometrial tissues. In addition to this, the lesions which were histologically diagnosed as endometriosis might sometimes include obsolete follicle cysts undergoing luteinization.

Adolescent↗
PubMed1985

Case report of malignant primary nerve sheath tumor arising in the female pelvis.

This paper reports a malignant primary nerve sheath tumor (MPNST) which originated in the obturator nerve in a 54-year-old woman. That the tumor originated in the nerve sheath is supported by the site of occurrence, which was consistent with the obturator nerve, an arrangement of cells similar to that in schwannoma, and that extracellular basement membrane was noted ultrastructurally. This tumor was classified not as malignant schwannoma but as a nerve sheath fibrosarcoma because the matrix of tumor tissues contained abundant mucinous materials, some tumor cells were fibroblastic, and the clinical change was rapid. In general, with plexiform neurofibroma there is a familial manifestation and it occurs as a complication of von Recklinghausen's disease, associations not demonstrated in this patient. From these findings, this tumor is considered to be an extremely rare nerve sheath fibrosarcoma which originated from a malignant change in a sporadic and solitary plexiform neurofibroma.

Collagen↗
PubMed1985

[Hormonal therapy of endometrial cancer].

Progestin therapy is indicated for advanced or metastatic endometrial cancer as well as a adjuvant therapy for primary cancer. There are several predictors of tumor responsiveness to the hormone. Sex steroid receptor(R) is a biochemical marker. Receptor analysis was done in 73 cases of primary endometrial cancer. The concentrations of estrogen (E), progestin (P) and androgen (A) were found to correlate with the degree of tumor differentiation; well-differentiated tumor contains significantly greater receptors than moderately-and poorly-differentiated tumors. Both ER and PR were positive in about 80% of the well-differentiated tumor, but negative in 50% of the poorly-differentiated tumors. Analysis of 13 cases of death shows some correlation of the PR concentrations with the survival time. Receptor dynamics in tumor of the patients enables us to predict possible site(s) of impaired responsiveness to progestin. Furthermore, in addition to progestin and estrogen test, tamoxifen challenge test is useful as in vivo sensitivity test. Moreover, receptor manipulation by tamoxifen may be employed to enhance hormonal sensitivity of the tumor, particularly the low receptor one.

Female↗
PubMed1985

[A case of leiomyosarcoma of the rectum with widespread lymph node metastases].

A case of leiomyosarcoma of is reported. A 78-year-old man was admitted with a history of constipation and deformation of the stools. Barium contrast study and sigmoidoscopy showed a submucosal tumor of the rectum. On computed tomography and angiography, the tumor was suspected of being leiomyosarcoma. Abdominoperineal resection was performed. Microscopic examination revealed a leiomyosarcoma of the rectum and widespread lymph node metastases were found. Leiomyosarcoma of the rectum is an uncommon tumor. In our country, 89 cases have been reported. Six had lymph node metastases initially and another six subsequently. We have referred to the literature on leiomyosarcoma of the rectum.

Aged↗
PubMed1984

Overlapping of the coding regions for alpha and gamma components of penicillin-binding protein 1 b in Escherichia coli.

The mode of biosynthesis of penicillin-binding protein(PBP)-1b in Escherichia coli was investigated by use of the plasmid carrying the ponB(PBP-1b) gene region. Analyses of the products synthesized in minicells and in vitro showed that PBP-1b was synthesized as two molecular species corresponding to the alpha and gamma components of PBP-1b. The coding regions for the alpha and gamma components were located within the ca. 3.7 kb MluI-HincII fragment and transcribed in the direction from the HincII to the MluI site. The capacity for producing the alpha component was abolished by a deletion extending to the MluI site ca. 0.7 kb inward from the HincII end of the ca. 3.7 kb fragment; the remaining 3.0 kb region with the MluI site at both ends directed the production of the gamma component alone. The production of the gamma component was enough to correct all the known defects caused by a ponB mutation. In addition to these results, the analyses for cross-reacting materials produced in correspondence to the various deletions indicated that the coding regions for the alpha and gamma components overlapped and that the N-terminal portion was responsible for the difference between the two components. The distal region about 0.7 kb long inward from the MluI end of the MluI-HincII fragment was dispensable for producing the functional PBP-1b, although the PBP-1b produced was curtailed. By a larger distal deletion reaching almost to the middle of the MluI-HincII fragment, the polypeptide produced for PBP-1b lost the ability to bind penicillin and still retained a low but significant activity for glycan synthesis.(ABSTRACT TRUNCATED AT 250 WORDS)

Acyltransferases↗
PubMed1984

The ontogeny of cytosol and nuclear progestin receptors in male rat brain and its male-female differences.

The fetal and postnatal development of the progestin receptor systems in the intact male rat brain was investigated by means of the in vitro cytosol binding and the nuclear exchange assay using [3H]R5020 [( 17 alpha-methyl-3H]17 alpha, 21-dimethyl-19-nor-4, 9-pregnadiene-3,20-dione). The cortical cytosol receptors, first detectable at day 0, rapidly increased at day 7, reaching a maximum at day 10, then gradually declined thereafter. The receptors in the HPOA appeared clearly at day 1, increased during the first 10 days, then remained constant at days 14-21. The postnatal developmental patterns of cytosol brain progestin receptors in males were essentially similar to those in females, but there were some differences between both sexes. The male HPOA at days 10-14 contained more receptors than the female one. Nuclear progestin binding was low in the neonatal male brain at days 1-3. Despite the low level of serum progesterone, the cortical nuclear binding suddenly increased at days 7-10, then remained high at days 14-21. A similar, though less pronounced, pattern was seen in the HPOA. The male pattern of nuclear binding, thus, essentially resembled the female one. However, lower binding in the cortex and, possibly, HPOA was found in males than in females at days 10-21. After progesterone injection postnatal male rats accumulated a lower concentration of progestin receptors in the cortex and, possibly, HPOA than similarly-treated females. It is concluded from these results that progestin receptors in male rat brain appear immediately after birth and develop differentially in the cortex and HPOA. The sudden onset of increased nuclear translocation of endogenous progestin receptor complexes may occur in the brain at around days 7-10. There is a marked sex difference in the nuclear progestin receptor system in the postnatal brain, particularly the cortex. Moreover, the postnatal male brain has lower capacities of nuclear receptor translocation than does the female one. The progestin receptor system in the cortex and, possibly, HPOA of rats in the early postnatal life might be involved with some processes in the mechanism of sexual differentiation of the brain.

Animals↗
PubMed1984

Bioconversion of arachidonic acid by human uterine cervical tissue and endocervix in late pregnancy.

Prostaglandins (PGs) may play an important role on cervical ripening in late pregnancy, namely cervical dilatation and softening. To investigate this, arachidonic acid metabolites of cervical tissue and endocervix were studied. To separate and identify the metabolites, silicic acid chromatography, thin layer chromatography, reversed phase chromatography, gas-liquid chromatography and GC-MS were used. In cervical tissue, arachidonic acid was converted to 6-ketoPGF1 alpha, PGF2 alpha, PGE2, thromboxane B2, and 12-HETE. In endocervix, arachidonic acid was converted to PGF2 alpha, PGE2, thromboxane B2, 12-hydroxy-5, 8, 10-heptadecatrienoic acid, and 12-HETE. There was no relation between the arachidonic acid conversion rate and the Bishop score (points of cervical ripening).

Adult↗
PubMed1984

Bioconversion of arachidonic acid to prostaglandins and related compounds in human myometrium and uterine cervix.

Arachidonic Acid metabolites in human myometrium and uterine cervix were studied using silicic acid column chromatography, thin layer chromatography, reversed phase partition chromatography and gas-liquid chromatography. Myometrium produced 6-ketoPGF1 alpha, PGF2 alpha, PGE2, thromboxane B2. Uterine cervix produced 6-ketoPGF1 alpha, PGF2 alpha, PGE2, thromboxane B2, and one hydroxyacid. There was no difference between the rate of conversion of prostaglandins in myometrium and cervix. But only cervix could convert arachidonic acid to hydroxyacid.

Arachidonic Acid↗