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Biomedical subjects

J Kaneti

Publications and source records attributed to J Kaneti.

At least 37 records · Page 2Linked to original sources
PubMed1992

Gonadotropin-releasing hormone specific binding sites in normal and malignant renal tissue.

Renal cell carcinoma has been reported to contain estrogen and progesterone receptors. Thus, it has been suggested that these tumors are hormone dependent in a similar manner described for the breast and prostate cancers. It has been recently shown that mammary and prostate tumor cells contain gonadotropin-releasing hormone (GnRH) receptors and are growth inhibited directly by GnRH antagonists. In this study we examined for the presence of GnRH, estrogen and progesterone receptors in normal and malignant renal tissues. Estrogen receptors were found both in the normal and malignant kidney while progesterone receptors were present only in the normal tissue. Specific binding of [125I]buserelin, a GnRH agonist, was evident in renal carcinoma and in normal kidney and was displaced with equal efficiency by unlabeled buserelin and by D-Trp6-GnRH, but not by unrelated peptides such as thyrotropin releasing hormone and oxytocin. The non-linear scatchard curve obtained for buserelin binding, suggests the presence of at least two binding sites, one with high affinity in the nanomolar range and another in the micromolar range.

Buserelin↗
PubMed1992

Testicular carcinoma with inferior vena cava thrombosis extending into the right atrium treated with chemotherapy and anticoagulation.

A 34-year-old male with pulmonary emboli and thrombosis of the inferior vena cava extending into the right atrium was found at presentation to have a mixed seminoma and embryonal cell testicular carcinoma with high-volume retroperitoneal disease and visceral metastases. The patient was free of disease 19 months after treatment with combination chemotherapy and anticoagulation followed by resection of the residual mass. We could not find any previous report of a patient with bulky retroperitoneal disease and vena cava thrombosis successfully treated with chemotherapy without vena cava resection.

Adult↗
PubMed1991

Perinephric inflammatory process following extracorporeal shock wave lithotripsy.

A patient with large branched staghorn calculi was treated with ESWL. She suffered from recurrent urinary tract infections. Following ESWL she developed a perinephric abscess, which necessitated percutaneous drainage. The clinical course is described and a possible pathogenesis of perinephric abscess following ESWL is suggested.

Abscess↗
PubMed1991

Cellular B-2 microglobulin expression as a prognostic indicator in renal cell carcinoma.

The expression of B-2 microglobulin (B-2M) on tumor cells and their normal cell counterparts in 39 patients with renal cell carcinoma was studied and correlated to tumor stage and survival. The median survival time of patients with localized disease (stage I) whose tumors expressed B-2M was 10.2 years while the median survival time for patients whose tumors did not express B-2M was only 3.6 years (p less than 0.001). For patients with more advanced disease (stages II, III, IV) whose tumors expressed B-2M, median survival time was 3.6 years compared to 2.0 years in patients whose tumors did not express B-2M, a non-significant difference. It is suggested that the tumor cell membrane expression of B-2M may serve as an indicator of good prognosis in early renal cell carcinoma.

Adolescent↗
PubMed1988

Embryonal carcinoma of testis in elderly men.

A rare case of pure embryonal carcinoma of the testis in a 63-year-old man is presented. The literature on germ cell tumours in men 60 years of age and older is also presented.

Age Factors↗
PubMed1988

Pelvi-uretero-cutaneostomy en-Y as a temporary diversion in children. Soroka experience.

Improved surgical techniques and instrumentation may facilitate an aggressive approach in correcting lower urinary tract abnormality in one stage in seriously ill children, but nevertheless be complicated and dangerous. Temporary diversion is still being used by some as a life-saving procedure as well as for salvage of the kidneys initially. Pelvi-uretero-cutaneostomy en-Y (PUC en-Y) has been proved to be a very useful approach with some advantages over the other temporary drainage procedures. The clinical material, indications, results and modifications are discussed. Reference is made to a case illustrating the potential danger of loop ureterostomy.

Female↗
PubMed1988

Agenesis of kidney associated with malformations of the seminal vesicle. Various clinical presentations.

Ureteral seminal vesicle anomaly associated with ipsilateral renal agenesis is a rare occurrence. Cystic anomaly of the seminal vesicle may be asymptomatic or discovered by rectal examination and cystoscopy for evaluation of bladder irritative symptoms, perineal and testicular pain, ejaculatory disturbances and rarely infertility. The condition was diagnosed in three patients with various clinical presentations.

Abnormalities, Multiple↗
PubMed1988

IgG and IgA antibodies specific for Chlamydia trachomatis in acute epididymitis.

The possibility of using elevated Chlamydia trachomatis-specific serum IgG and IgA as a screening test for Chlamydia-associated epididymitis was analyzed in 28 acute epididymitis patients and 42 apparently healthy men by the single antigen (L2) immunoperoxidase assay. The prevalence rates of C. trachomatis IgG antibody titer greater than or equal to 64 and elevated C. trachomatis IgG titers (greater than or equal to 128) were significantly higher in the epididymitis patients (75 vs. 40%, p less than 0.01, and 39 vs. 14%, p less than 0.025, respectively) than in controls. The prevalence rate of C. trachomatis IgA antibodies (titer greater than or equal to 8) was significantly higher (p less than 0.001) in epididymitis patients as compared to controls (46 vs. 10%, respectively). The potential application of elevated serum C. trachomatis IgG and IgA antibodies as a noninvasive screening marker in epididymitis patients is discussed.

Adult↗
PubMed1988

Fate of nonneurogenic neurogenic bladder--end-stage renal failure.

The nonneurogenic neurogenic bladder syndrome which actually comprises a large spectrum of clinical radiological, psychological and behavioral disorders, is manifested by bladder-sphincter incoordination and constitutes a very complex problem of overall management. The condition refers to infravesical functional obstruction in children in whom no anatomic or neurological defect is demonstrated. Although the etiologic bases are often unclear, successful management of urinary infection and reflux and prevention of upper tract deterioration are achievable by multidisciplinary conservative measures, sometimes reinforced by ureteric reimplantation. End-stage renal failure due to this syndrome is a rare complication. The presented case demonstrates well all the clinical features of this syndrome, which unfortunately ended in hemodialysis.

Adolescent↗
PubMed1987

Vascular polyps of ureter associated with megacalycosis and nephrolithiasis.

Multiple benign vascular polyps of the ureter are rare, and the associated congenital megacalycosis and nephrolithiasis are very uncommon. Herein we report a case with vascular polyps of the right ureteropelvic junction dissociated with extensive hydronephrosis which was considered to be megacalycosis. Clinical features and treatment modalities are reviewed.

Adolescent↗
PubMed1987

Fibroepithelial polyp of the renal pelvis.

Benign tumors of the renal pelvis are rare, with less than 10 cases reported in the literature. The fibroepithelial polyp, a benign mesodermal tumor, seems to be the most common type. We report a case of a fibroepithelial polyp of the renal pelvis, and discuss its clinical features and diagnostic pitfalls.

Adult↗
PubMed1986

Partial cystectomy in the management of bladder carcinoma.

We reviewed 62 patients who had undergone partial cystectomy for carcinoma of the bladder. Specific indications are discussed. Five-year survival rates were 68% for stage 0-A lesions, 40% for stage B (B1 and B2), 30% for stage C and none survived even 3 years in stage D. Overall 3- and 5-year survival were 57 and 50%. Fifty-four patients have been followed for 10 years and the survival rate for this group of patients was 22% (12 patients). There was 1 death in the immediate postoperative period. The recurrence rate was 38% of which only 1 patient needed radical cystectomy while the others were controlled by transurethral resections. Reimplantation of ureters was performed in 35 patients (56%) which is a high percentage compared with other series. Postoperative irradiation was given to 41 (66%) patients, all of whom were in stages greater than or equal to B disease. Five patients (1 stage C and 4 in stage B) were operated upon during the last 2 years with no evidence of recurrence so far. The results of this review were encouraging and correlated well with other published reports.

Adult↗