Search PubMed⌕ Search

Biomedical subjects

J Justus

Publications and source records attributed to J Justus.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Morphologic studies on the occurrence of HBs antigen in liver cirrhoses, epicirrhotic and pure cancers in a large autopsy sample].

1063 hepatic cirrhoses, 138 epicirrhotic carcinomas, and 138 carcinomas without cirrhosis from the autopsy material of the Dresden region obtained from 1970 to 1979 were examined for the occurrence of HBsAg by means of reclassification and after-staining of the documented section material with orcein staining according to Shikata. The portion of the post-B-hepatic cirrhoses of the liver was 95 (8.9 per cent of the total material). In epicirrhotic carcinomas a HBsAg-containing cirrhotic portion was identified in 14 cases (10.1 per cent), whereas hepatic tissue of carcinomas without cirrhosis never showed HBsAg. A relation between the activity degree of the hepatic cirrhosis and the quantity and distribution of HBsAg could not be established. The found out numbers (about equally frequent occurrence of HBsAg in hepatic cirrhosis and epicirrhotic carcinomas, no identification in the hepatic tissue of carcinomas without cirrhosis) reveal that the thesis of a hepatocarcinogenic effect of the hepatitis B virus cannot be supported by the histologic identification of HBsAg in our investigational material. The possibility of confusion of ground-glass hepatocytes with liver oncocytes in the HE-stained section material of the autopsy material is pointed out.

Aged↗
PubMed1982

Storage of the complement components C4, C3, and C 3-activator in the human liver as PAS-negative globular hyaline bodies.

Liver biopsies of a 58-year-old clinically healthy patient with a hepatomegaly and intracisternal PAS-negative globular hyaline bodies were immunofluorescent-optically examined for the content of the complement components C 1 q, C 4, C 9, C 1-inactivator, C 3-activator. Further examinations were performed for fibrinogen, IgG, IgA, IgM, IgD, IgE, L-chain (type chi and lambda), alpha 1-antitrypsin, alpha 1-fetoprotein, alpha 1- and alpha 2-glycoprotein, cholinesterase, ceruloplasmin, myoglobin, hemopexin, HBsAg and HBsAg. Th inclusion bodies reacted with antisera against the complement components C 4, C 3 and C 3-activator, as also identified by double immunofluorescence. Probably this is a disturbance of the protein metabolism of the liver cell with abnormal complement storage in the presence of normal total complement and normal complement components in the serum.

Complement Activating Enzymes↗
PubMed1981

[Finding and significance of copper protein complexes in liver cirrhoses (author's transl)].

302 liver cirrhoses obtained from the post-mortem material 1970 to 1979 have been examined for the occurrence of the cuprous protein complexes by means of the orcein-staining according to Shikata. The part of the B-posthepatic cirrhoses (89%) could be simultaneously determined with the help of this method. Cuprous protein complexes have been found in bilious (100%), alcoholic (43.9%), etiologically uncertain (34.4%), and B-posthepatic (25,9%) liver cirrhoses. They prove an existing or experienced chronic cholestasis. The demonstration of copper has no principal significance for the etiologic classification of cirrhoses. In the bioptic diagnostics the demonstration of copper has a certain significance for the differentiation of the primary destructive cholangitis from chronically active hepatites of other genesis. The investigations incidentally revealed that HBsAg-containing hepatocytes could be identified by means of orcein in sections performed on archive material after destaining independent of the age of the sections and their primary staining.

Copper↗
PubMed1980

[Value of cytological diagnostic in differential diagnosis and staging of lymphogranulomatosis (author's transl)].

Report on 38 cases with thoracic x-ray changes in Hodgkin's disease in a lung clinic. One third of the cases was found by preventive investigations (VRRU). There are various roentgenologic pictures. In 24 from 31 cases neck lymphonodules were involved. In 24 cases diagnosis of Hodgkin's disease was primarily made by cytologic fine needle biopsy of neck lymphomas, perbronchial or parasternal punctions. Only in 2 cases surgical bioptic intervention would have been necessary. There was no false positive cytological diagnosis. Fine needle biopsies in abdominal staging interventions are recommended.

Biopsy, Needle↗
PubMed1978

[Sclerodermiform paraneoplastic syndrome during a kidney carcinoma].

Sclerodermiformous alterations of the skin are described as paraneoplasia in different malignant tumours. By an own observation sclerodermiformous alterations of the skin are described for the first time as paraneoplasmia in a female patient aged 60 with nephrous carcinoma. The cutaneous efflorescences receded after elimination of the tumour.

Female↗