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Biomedical subjects

J Justus

Publications and source records attributed to J Justus.

At least 19 recordsLinked to original sources
PubMed1991

[The biological behavior of exocrine pancreatic carcinoma from a pathological-anatomical viewpoint. A contribution to the problems of surgical therapy].

The general biologic behaviour of exocrine pancreatic cancer was examined retrospectively in a total of 840 autopsies (382 males, aged 31-86 [average 66.5] and 458 females, aged 2-90 [average 72]). 95 % of autopsies showed definable tumours (caput 64%, corpus 17%, cauda 14%), in 5% the gland was diffusely permeated by cancer tissue. 19.5% had no metastases, whereas in 80.5% carcinomatosis was diagnosed. In 7% only locoregional metastases of the lymph nodes could be found. Tumour sizes were observed in the range of 0.3 to 14 cm. All carcinomas below the size of 1 cm were free of metastases. In tumours larger than 2 cm, the formation of metastases increased sharply. In sizes more than 3 cm complications were important for the prognosis. Carcinomatosis proceeds cascade-fashion with high first rate metastatic spread into the liver. 6% of liver metastases were solitary ones, 94% were multiple. In 171 cases malignancy grading was performed. Free of metastases were 50% of the decreased with grade-I-carcinomas, 21% with grade-II-carcinomas and 7% with grade-III-carcinomas. These data comment on the possibilities and limitations of curative cancer resection from a morphological view.

Adult↗
PubMed1990

[Epidemiology of cancer of the exocrine pancreas 1979-88 in the area of Dresden].

In the catchment area of two Pathological Institutes in Saxony with a population of approximately 1.3 million people all autopsies with the diagnosis of exocrine pancreatic cancer were evaluated with respect to age and the number of autopsies carried out in the period of the past ten years (1979-1988). The trend of this type of cancer within this group of all dissected cancer patients was followed. Absolute increase rates of 48% for males and 32% females could be calculated. An increasing incidence of pancreatic cancer was observed not only in the 7th and 8th decade of live--as was typical so far--but also from the age of 50 years onwards. Rates of increase were also found with regard to all cancer autopsies: 6% for males and 34% for females. The data agree with other observations of an increased pancreatic cancer incidence in all industrialized countries.

Adult↗
PubMed1988

[Assessment of positive cytologic and/or colposcopic findings in the uterine cervix in pregnancy].

When cytologic and colposcopic findings are atypical during pregnancy, a differentiated diagnostic approach is necessary for the sake of an undisturbed course of pregnancy. Scraping of the portio with cervical curettage--a procedure with a low complication rate--for provisional diagnosis (to rule out an invasive carcinoma) permits a definitive diagnosis to be established after lying-in. Problems are pointed out.

Adolescent↗
PubMed1988

[Liver morphology and clinical aspects of a case of cholesterol ester storage disease].

Liver specimen morphology and clinical course of a case of cholesterol ester storage disease are presented. In a 16-year-old boy on the first biopsy a massive storage of neutral fats was found light microscopically and of cholesterol ester micropolariscopically. Advanced portal field fibrosis and severe reactive hepatitis indicate the danger of progression up to metaplasia. Typical membrane-surrounded lipid inclusions were found electron microscopically in hepatic cells, stellate cells and also in bile duct epithelium.

Adolescent↗
PubMed1988

[Lymphogenous metastasis of urinary bladder cancer].

In 83 patients with locally curable bladder cancer of stage T1-T3 an exploratory pelvic lymphadenectomy was performed. The rate of metastases in all patients was 15.66%. In the analysis of lymphogenous metastasizing routes an obligatory direct deposition primarily in the lymph nodes of the obturatorius and/or external group with constantly by-passing of the viscero-vesical nodes was found. From this some conclusion to a modified technical-tactical approach of the exploratory pelvic lymphadenectomy have been done.

Humans↗
PubMed1988

[Drug-induced hepatitis after dihydralazine treatment with fatal consequences].

Adverse drug side effects of the antihypertensive substance dihydralazine have been increasingly observed in recent years. Damage is concentrated on the liver and is characterized by drug-induced hepatitis with confluent necrosis. Three cases (60 year old woman, 79 year old woman, 61 year old man) with lethal course after antihypertensive treatment, using dihydralazine are reported in this paper.

Aged↗
PubMed1978

[Sclerodermiform paraneoplastic syndrome during a kidney carcinoma].

Sclerodermiformous alterations of the skin are described as paraneoplasia in different malignant tumours. By an own observation sclerodermiformous alterations of the skin are described for the first time as paraneoplasmia in a female patient aged 60 with nephrous carcinoma. The cutaneous efflorescences receded after elimination of the tumour.

Female↗