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Biomedical subjects

J Jirka

Publications and source records attributed to J Jirka.

At least 73 records · Page 4Linked to original sources
PubMed1978

Possibilities of dynamic scintigraphy in renal allografts.

Dynamic scintigraphy, a non-invasive method, is suitable due to its sparing procedure in particular in clinical conditions where more pretentious examination methods are contraindicated or risky. Very frequently it can serve as a guide for more aimed examination methods. Its diagnostic value is great in particular where pathological conditions of the efferent urinary pathways are concerned, i.e. above all fistulae. In parenchymatous lesions it provides information on focal processes of an inflammatory and non-inflammatory nature. Investigation of both functions, of perfusion and transport of hippuran is sometimes a supplement for the differentiation of ATN and rejection nephropathies. The distribution of perfusion after administration of technetate helps to detect occlusion of the afferent arteries and minor arterioles.

Adult↗
PubMed1978

Urea and ammonia excretion into gastric juice in regularly dialyzed patients and patients after renal transplantation. I. Dialyzed patients.

In regularly dialyzed patients in basal gastric juice and after stimulation with pentagastrin the volume of titrable acidity, urea and ammonia were assessed. It was revealed that in relation to the plasma urea concentration in basal juice the mean urea and ammonia concentration is roughly half and in stimulation juice roughly one third. The urea concentration in gastric juice is negatively correlated to the ammonia concentration. Urea excretion into the stomach depends on the plasma urea level and on the secretory gastric activity. The decisive factor of gastric secretion is probably parietal cell secretion. From the results ensues that gastric juice of dialyzed patients contains a quantitatively significant amount of urea and ammonia. Ammonia due to its neutralizing action distorts the examination of gastric acidity assessed by titration. The findings call for a revision of hitherto known data concerning gastric secretion of uraemic patients.

Ammonia↗
PubMed1976

Human serum Zn-alpha 2-glycoprotein in renal disease.

The serum concentrations of Zn-alpha 2-glycoprotein (ZnaGP) were found to be increased in renal patients with both normal and restricted function; in the latter they showed significant correlation with serum creatinine and urea levels and a decrease after haemodialysis. Renal clearance of ZnaGP studied in four subjects was found to be from 0.1 to 0.8 per cent of that of inulin, and its excretion fraction was inversely proportional to the level of inulin clearance. The significance of the association of hyper-ZnaGP-aemia with renal pathology is unknown; it is supposed to be due rather to some defect in metabolic function of the kidney (utilization or degradation) than to restricted excretion, and its decrease after haemodialysis-with dialysis membrane not permeable to ZnaGP - to be caused by other factors than by the removal of the protein from the body.

Adult↗
PubMed1976

Clinical detection of rejection nephropathy using 125I-labelled fibrinogen.

Using a modified fibrinogen-uptake (FUT) test, 22 patients were investigated at various intervals after kidney transplantation. Eight of the patients had developed or showed early clinical signs of acute rejection crisis at the time of measurement. Another fourteen patients formed the control group with no evidence of florid rejection process. Comparison of the 125I-fibrinogen accumulation in the renal grafts between the two mentioned groups showed clear differences with high statistical significance (p less than 0.001). Uptake of labelled fibrinogen was increased in every acute rejection transplant. Histologically the kidneys with increased accumulation of fibrinogen showed extensive deposits of fibrin in blood vessels, glomeruli, intracapillary thrombi and in the interstitium. Except for the limitations discussed in this paper we consider this test to be of a great clinical value in the diagnosis of rejection episodes.

Female↗
PubMed1976

Decrease of endothelaemia during immunosuppression.

The counts of circulating endothelial cells estimated by a new quantitative method were significantly decreased in a group of patients after renal transplantation. Subsequent animal studies have shown that such a decrease may be attained by the administration of immunosuppressive drugs. The explanation of this observation may be based on the suppression of a normal endothelial cell replacement.

Animals↗