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Biomedical subjects

J Jirka

Publications and source records attributed to J Jirka.

At least 55 records · Page 3Linked to original sources
PubMed1983

Simulated proteinuria and haematuria.

In nephrology, like in other branches of medicine, falsification is motivated by a desire for profit or is an expression of some mental disorder. Three cases are described in which artificial proteinuria and haematuria were diagnosed by agarose gel electrophoresis of urinary proteins and a simulation and aggravation of renal disease was disclosed.

Adult↗
PubMed1983

Spironolactones and glomerular filtration.

For pharmacologic screening to identify hyperaldosteronism in patients after renal transplantation, spironolactone (Soludactone, Searle) was administered intravenously in 12 subjects (mean dose 1.2 g in the course of 3 days). After its administration a decrease in glomerular filtration rate was assessed when measured by chromogen clearance. Simultaneous measurement of creatinine showed no change, nor was there any change in the plasma level and excretion fraction of urea. The decrease in chromogen clearance was due to an increase in plasma level of the chromogen. Thus the decrease in its clearance was an artifact resulting most probably from the reaction of spironolactone metabolites with alkaline picrate, which was used for the determination of chromogen. In addition to the causes of the glomerular filtration rate decrease after spironolactone which have been reported in the literature - volume depletion and direct influence on the kidneys - the possibility of a fictive decrease must be taken into consideration.

Adult↗
PubMed1981

Schematic and controlled immunosupression after renal allotransplantation.

On the basis of 15-years' experience with the allogeneic transplantation of the kidney, the authors present recommendations, concerning the dosage of azathioprine and prednisone (methylprednisolone) during the schematic immunosuppression. There are favourable first experiences with the immunosuppression controlled according to continuous following of the count of lymphocytes able to form rosettes E (degree of immunosuppression) and that of functional granulocytes (toxicity).

Azathioprine↗
PubMed1980

Renal allograft function and cytomegaly.

A retrospective study in 20 seronegative and 61 seropositive (complement fixation) first cadaver donor graft recipients brought evidence that in cytomegaly, not the infection alone, but curtailment of azathioprine shortly after transplantation (or summation of both) may result in rejection and impaired graft survival. Preliminary data (accumulation of 125I-labelled fibrinogen in two and morphology of the graft in two other patients) showed that depression of graft function in cytomegaly is not necessarily due to rejection.

Azathioprine↗
PubMed1978

Contribution to the problem of the relationship of infection and rejection in patients with kidney transplants.

The paper deals with the incidence of infectious complications and rejection crises in patients with renal transplants. It was revealed by statistical methods that there exists a certain correlation between infections and rejections, which depends on the type of the infectious agent. In patients where infectious complications were caused only by gram-negative flora an indirect relationship was revealed, while in patients with infectious complications where gram-positive flora, viruses or fungi participated, a marked direct correlation was found. Statistical methods proved also a higher incidence of rejection crises in patients with active cytomegalic infection.

Cytomegalovirus Infections↗
PubMed1978

Influence of protein intake and renal function on plasma amino acids in patients with renal impairment and after kidney transplantation.

A group of 17 patients with chronic renal impairment and a group of 11 patients surviving for 3--7 years after kidney transplantation were examined. In all patients plasma amino acids were analyzed. The ratio of essential/nonessential amino acids, the valine/glycine ratio and Whitehead's quotient are influenced above all by the dietary protein intake. Raised citrulline and 3-methylhistidine values were not influenced by the protein intake, while they correlate with indicators of renal function. Changes detected after kidney transplantation are analogous.

Adult↗
PubMed1978

Miliary tuberculosis in a patient after renal transplantation.

A report is presented on the first case of miliary tuberculosis in a group of 84 kidney transplant recipients treated in the Institute of Clinical and Experimental Medicine, Prague, until March 1976. The specific process was verified by bacteriological investigations of the sputum and urine. Productive specific tuberculoid-type nodules with sporadically occurring acidoresistant rods were detected in a bioptic specimen of the transplanted kidney. Also discussed are therapeutical problems in progressive renal graft insufficiency and in simultaneous chronic hepatopathy.

Adult↗
PubMed1978

Renal transplantation and pregnancy.

Processing of data from 79 pregnancies (incl. 11 observed by the authors) in 64 women (incl. 6 of their own patients) after renal transplantation revealed that approximately in 20% of the pregnancies in chronological association with the pregnancy the function of the graft deteriorated or ceased and in four instances this participated indirectly in the mother's death within one year after delivery. The effect of immunosuppressive treatment of the pregnant mother on the development of the foetus and 57 evaluated infants resp. was manifested by a 50% incidence of prematurity, in seven neonates by clinical or post-mortem findings of adrenal hypofunction or hypoplasia resp. and by hypofunction or hypoplasia of the lymphatic apparatus. Only in one neonate and one foetus (observed by the authors) an inborn defect was revealed. In five neonates chromosomal aberrations were described. The above findings support our disapproval of pregnancy in women after renal transplantation with the exception of recipients of grafts from siblings with closely related tissue properties and with a renal function stabilized for a long period and with minimal immunosuppression.

Chromosome Aberrations↗