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Biomedical subjects

J J Ryan

Publications and source records attributed to J J Ryan.

At least 181 records · Page 10Linked to original sources
PubMed1984

Validity of the Narcissistic Personality Inventory (NPI) in a psychiatric sample.

Investigated the validity of the Narcissistic Personality Inventory (NPI) in a psychiatric sample. Fifty psychiatric patients were given the NPI as part of a routine psychological evaluation. Correlations between the NPI and the basic personality style scales of the Millon Clinical Multiaxial Inventory (MCMI) were obtained; the largest correlation was between the NPI and the narcissism scale of the MCMI (r = .66, p less than .001). When classified into the low and high narcissistic groups, there was 74% agreement between the NPI and narcissistic scale of the MCMI. These results provide further support for the construct validity of the NPI.

Adult↗
PubMed1984

Wechsler performance IQ greater than Verbal IQ index in a forensic sample: a reconsideration.

Explored the relationships of the Performance IQ (PIQ) greater than Verbal IQ (VIQ) to type of crime, ethnicity, and reading disability in a corrections sample of 70 adult males incarcerated on felony charges. The PIQ greater than VIQ sign was not related to Full Scale IQ or to violent vs. nonviolent crime, per se. The PIQ greater than VIQ sign showed a trend toward association with Ethnicity (black vs. white) and was related significantly to reading disability, with the reading disabled inmates more likely to show the sign, and to type of crime, with perpetrators of sex crimes most likely (87%) to show the sign and those incarcerated for murder or attempted murder least likely (33%) to show it. The difference in the proportion of inmates who showed the sign in these two classes of violent crimes (murder and sex crimes) was significant, and further analysis showed that with murder excluded, PIQ greater than VIQ occurred significantly more frequently in those accused of violent crimes than for nonviolent crimes. The latter findings suggested that differences between studies in the relationship of PIQ greater than VIQ and violence may be the result of differences in the proportion of murderers in the violent samples. Additional analyses indicated that the significant relationships between PIQ greater than VIQ and both type of crime and reading disability were most likely independent of ethnicity and each other.

Adolescent↗
PubMed1984

Validity of the Verbal IQ as a short form of the Wechsler Adult Intelligence Scale-Revised.

Assessed the validity of the Verbal IQ as a short form of the WAIS-R. Ss were 104 psychiatric patients with means for age, education, and Full Scale IQ of 36.22 (SD = 9.04), 12.46 (SD = 1.98), and 93.94 (SD = 12.19), respectively. A correlation of .93 (p less than .001) between the Verbal and Full Scale IQs was found. The average Verbal IQ exceeded the average Full Scale IQ by a small (i.e., 1.65 IQ points) but statistically significant amount (p less than .001). Thirty-three (32%) Ss showed changes in their intelligence categories when the Verbal IQ was compared to the Full Scale IQ. However, when the Verbal IQ was banded by the standard error of measurement (SEM = +/- 3) and the precision range was compared to the Full Scale IQ, results indicated 88% agreement. If clinicians must rely on the Verbal IQ as an estimate of the Full Scale, reporting the score in conjunction with a precision range will increase its accuracy.

Adult↗
PubMed1984

Rey Auditory-Verbal Learning Test performance of patients with and without memory impairment.

Investigated performance on the Rey Auditory Verbal Learning Test (AVLT) of 92 psychiatric and neurological patients classified as memory-impaired (N = 45) or non-memory-impaired (N = 47). The groups were comparable on age and education. Relative to the non-memory-impaired Ss, performance of the memory-impaired patients was significantly lower on all AVLT scores, ps less than .01. The AVLT appears to hold promise as a quick screening measure for the clinical evaluation of patients with suspected verbal learning and memory impairments.

Diagnosis, Differential↗
PubMed1984

Application of the four-subtest WAIS-R short form with an older clinical sample.

Investigated the validity of the Arithmetic + Vocabulary + Picture Arrangement + Block Design subtest combination as an estimate of the WAIS-R Full Scale IQ in a sample of 55 elderly patients. The correlation between the short-form IQ and the WAIS-R Full Scale IQ was highly significant, r(53) = .95, p less than .001. A pairwise t-test computed between the mean IQs for the two forms was nonsignificant, t(54) less than 1. Approximately one-fourth of the Ss showed changes in intelligence classification levels when the short form was used. The short form does not provide a precise estimate of IQ; however, it appears to have clinical utility as a screening device to identify patients with atypical cognitive functioning. The short form correctly categorized 84% of the current sample with respect to the presence or absence of abnormalities on the full WAIS-R.

Aged↗
PubMed1984

In vivo and in vitro binding of alpha- and gamma-hexachlorocyclohexane to mouse liver macromolecules.

alpha-Hexachlorocyclohexane (alpha-HCH) but not gamma-HCH, produces a strong neoplastic response in HPB strain mouse liver. In vivo and in vitro binding studies with 14C-labelled HCH isomers showed no preferential binding of the alpha-HCH isomer to protein or DNA. Moreover, the binding of both isomers to DNA in vivo or in vitro occurred only at very low levels, a result consistent with the lack of mutagenic activity associated with these compounds. The results suggest that the neoplastic response observed with alpha-HCH results from a non-genotoxic mechanism.

Animals↗
PubMed1984

Recognition and response to alloantigens in vivo. II. Priming with accessory cell-depleted donor allogeneic splenocytes: induction of specific unresponsiveness to foreign major histocompatibility complex determinants.

Although the role of non-T, non-B Ia+ accessory cells as the cells that stimulate alloreactive T cells in vitro has been carefully examined, the capacity of such accessory cells to trigger host T cells in vivo has been considerably less well studied. Therefore, to address the latter issue, this investigation compared the ability of accessory cell-containing and accessory cell-depleted donor cells to mediate in vivo negative and positive selection of mixed lymphocyte reaction (MLR)-responsive peripheral blood lymphocytes (PBL). It was observed that both unseparated and accessory cell-depleted (Sephadex G-10-passed) allogeneic splenocytes, which expressed similar levels of Ia antigens as detected by flow cytometry, were equally efficient in inducing temporary specific unresponsiveness to alloantigens in host PBL 24 hr after donor cell injection. In contrast, 4 days after priming with unseparated major histocompatibility complex (MHC)-incompatible splenocytes, specific MLR hyperresponsiveness was detected in the PBL of these recipient mice, whereas specific hyporesponsiveness was consistently noted in animals injected with accessory-cell depleted splenocytes. PBL obtained from this latter group of mice continued to be specifically reduced in MLR proliferative capacity throughout the culture period and for at least 13 days after administration of accessory cell-depleted allogeneic splenocytes. Mixture of these MLR hyporesponsive and hyperresponsive PBL did not identify suppressor cells as responsible for the specifically lowered proliferative potential. These findings are discussed in the context of discrete signals required for T cell recognition and T cell activation.

Animals↗
PubMed1984

Recognition and response to alloantigens in vivo. I. Negative and positive selection of MLR reactivity in murine peripheral blood lymphocytes to major histocompatibility complex and Mls antigens.

Specific mixed lymphocyte reaction (MLR) responsiveness to allogeneic major histocompatibility complex (MHC), or minor lymphocyte-stimulating (Mls) determinants, was depleted in the peripheral blood lymphocytes (PBL) obtained from mice 24 to 48 hr after i.v. injection of 5 to 7.5 X 10(7) MHC or Mlsa-incompatible spleen cells, respectively. Results of cell mixture experiments suggest that the generation of suppressor cells was not the explanation for this specific reduction in MLR proliferation occurring with these PBL responder cells. To gain additional insight into parameters involved in the recognition of allodeterminants in vivo, experimental manipulations of the host environment and donor cell inoculum utilized in the negative selection procedure were employed. For example, removal of the spleen in the recipient animal, an anatomic site in which injected allogeneic cells and corresponding host antigen-reactive cells (ARC) are trapped, still permitted the specific depletion in murine PBL of host ARC for donor foreign MHC antigens. This finding may implicate other sites such as the liver where unprimed host alloreactive clones are trapped. In addition, irradiation of allogeneic donor cells significantly reduced their capacity to trap alloreactive T cell clones in vivo, whereas heat treatment of the donor cells completely eliminated this ability, even though the Ia determinants were still expressed, measured by flow cytometry. After the negative selection period, kinetic analysis of proliferation showed that 3, 4, or 5 days after injection of MHC-incompatible allogeneic spleen cells, the PBL of the recipient showed specific hyperresponsiveness to the MHC-haplotype of the donor cells. Interestingly, these primed PBL responder cells had the volume distribution of small resting cells; thoracic duct lymphocytes (TDL), positively selected by adoptive transfer of T cells to irradiated semiallogeneic recipients, are reported to be mainly blast cells. In contrast to the MLR hyperresponsiveness that results from priming with MHC-incompatible splenocytes, PBL, obtained at these later time points from mice primed with Mlsa-incompatible, H-2-compatible splenocytes, showed complete unresponsiveness in MLR to these Mlsa-bearing stimulator cells, as well as some nonspecific reduction in proliferation to MHC-incompatible stimulator cells regardless of their Mls genotype.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1984

Expression of Lyb-5 and Mls determinants by Peyer's patch B lymphocytes of X-linked immunodeficient mice.

Treatment of the Peyer's patch (PP) B cells from X-linked immunodeficient (xid) (CBA/N X DBA/2)F1 male mice with anti-Lyb-5 plus complement kills approximately 75% of these cells, although xid spleen B cells are unaffected. Cytotoxic depletion of Lyb-5+ cells renders the xid PP B cell population unable to generate an in vitro direct plaque-forming cell response to the TI-2 antigen TNP-Ficoll. In addition, the B cell-enriched population from the PP of xid (CBA/N X CBA/J)F1 male mice were strong stimulators of proliferation in an M1s-defined MLR, thereby demonstrating that they also express the M1s antigen(s). Two cell surface antigens associated with mature B cells are therefore expressed by xid PP B cells, suggesting that the TNP-Ficoll responsive cells in this population are mature B cell.

Animals↗
PubMed1984

Symmastia: the problem of medial confluence of the breasts.

This paper presents the problem of medial confluence of the breasts producing a web across the midline. Significant references in the literature dealing with uncommon clinical problems are virtually nonexistent. The purpose of this paper is to stimulate discussion of this entity and its surgical management and to propose the term symmastia to facilitate retrieval of information about this entity in the future. Two cases that highlight the central problem but which differ in the specifics of the surgical approach are presented. In the first case, the medial web was corrected by elevating an inferiorly based triangular skin flap that was advanced superiorly in an inverted Y-V manner after the excess medial soft tissue was divided and sutured superiorly to the medial pectoralis fascia to create a brassiere-band sling effect. In the second case, a superiorly based medial flap containing both skin and soft tissue was elevated. The excess skin and soft tissue were then excised. The remaining flap was tailored to fit into a V-shaped defect in the inferior incision to place the scar in a less viable place inferior to the sternum. The relative advantages of the two surgical approaches are discussed and a third approach based on the strengths of the two approaches is suggested. This approach would consist of the vertical division and superior rotation of the excess subcutaneous tissue flaps and the elevation of a superiorly based skin flap inserted into a V-shaped defect in the inferior incision.

Adult↗
PubMed1984

The lower thoracic advancement technique in breast reconstruction.

This technique, which uses local tissues, allows a modest supplementation of prethoracic skin coverage and creation of a stable, well-defined inframammary fold. With placement of a subpectoral implant, there is progressive expansion of the inferior and lateral skin coverage, resulting in progressively more natural ptotic shape. This expansion also allows subsequent increases in implant volume if appropriate. Advantages include good match of skin color and texture, confinement of donor site scarring to the relatively inconspicuous inframammary fold area, and relative ease of performance.

Breast↗
PubMed1983

A method for size separation of murine spleen cells using counterflow centrifugation.

A method for the rapid separation of murine spleen cells into subpopulations on the basis of their size has been developed using counterflow centrifugation. Upon separation of normal spleen cells with a mean cell volume of 125.5 +/- 6.0, 5 fractions of cells were obtained with mean cell volumes which ranged from 107.8 +/- 3.2 microns3 in fraction 1 to 152.7 +/- 4.9 microns3 in fraction 5. The cells in these 5 fractions were characterized by analysis on a fluorescence activated cell sorter (FACS) after staining with fluorescein conjugated anti-mu, delta, Ia, or Thy 1.2 antibodies, and by assaying for the presence of non-specific esterase activity. Surface Ig+, Ia+ B lymphocytes and Thy 1.2 T lymphocytes were present in all 5 fractions. However, while these T and B lymphocytes accounted for virtually all of the cells in the first 3 fractions, non-T, non-B cells were found in fractions 4 and 5, and represented 30% of the total population in the 5th fraction. Comparison of the intensity of anti-mu, delta or Ia staining of the B cells in fractions 1-5 revealed differences which suggested that B cell size correlated with different activation states of these cells. Increases in the intensity of the staining of T lymphocytes by anti-theta antibodies were also noted in the various fractions. The capacity of the B and T cells in each fraction to proliferate to B or T cell mitogens, respectively, was proportional to their frequency within the fractions. By contrast, the fractions containing larger cells were enriched in cells which proliferated in vitro in the absence of added mitogen. Furthermore, only fractions containing larger cells had the capacity to stimulate allogeneic T cell proliferation in a mixed lymphocyte reaction. Our data suggest that this technique provides a useful method for separating splenocytes on the basis of cell size. Use of this methodology provides a way to correlate cell size with phenotypic surface markers and functional abilities.

Animals↗
PubMed1983

Cognitive functions in tardive dyskinesia.

Cognitive functions of psychiatric patients with and without tardive dyskinesia were evaluated using the Wechsler Adult Intelligence Scale, Wechsler Memory Scale and Rey Auditory Verbal Learning Test. Schizophrenic patients with and without tardive dyskinesia did not differ in their performance on the administered psychological tests. However, affective disorder patients with tardive dyskinesia showed significantly more impairment on the Wechsler Memory Scale and Rey Auditory Verbal Learning Test than affective disorder patients without tardive dyskinesia. These findings suggest that affective disorder patients who develop tardive dyskinesia may have some predisposing brain damage or that tardive dyskinesia in these patients represents both a motor and a dementing disorder.

Antipsychotic Agents↗
PubMed1983

Dose proportionality of amrinone.

Amrinone was given to 18 healthy subjects in doses of 75, 150, and 225 mg in a randomized crossover design. Plasma levels were shown to rise in proportion to dose. The mean plasma AUC, extrapolated to infinite time, was determined for each dose level; the values obtained were 4, 8.18, and 12.35 micrograms . hr/ml for the 75-, 150-, and 225-mg doses. Mean maximum observed plasma concentrations were 1.03, 1.74, and 2.58 micrograms/ml. At higher doses the extrapolated AUC is more variable, but it is linear over the range of 0.73 to 3.81 mg/kg. The apparent first-order terminal elimination rate is not dose dependent and corresponds to a t1/2 of 3.85 hr.

Adult↗
PubMed1983

On substituting the WAIS-R for the WAIS in neuropsychological assessment: a caution for clinicians.

The Wechsler Adult Intelligence Scale-Revised (WAIS-R) yields lower Full Scale IQs than the Wechsler Adult Intelligence Scale (WAIS). Thus, a prediction about a patient's neuropsychological functioning based on the WAIS-R will differ from that based on the WAIS. The present study compared predicted Halstead Category Test (HCT) error scores based on the WAIS-R with those based on the WAIS. Thirty-five patients with the neurological and/or psychiatric conditions completed the HCT and WAIS-R, while 35 diagnostically similar patients were given HCT and WAIS. Regression equations to estimate HCT error scores were developed with the use of appropriate Full Scale IQs as the predictors. Results indicated that predicted HCT error scores were higher with the WAIS Full Scale IQ than with the WAIS-R. When the WAIS-R is substituted for the WAIS in a neuropsychological battery, the established relationship between IQ and expected neuropsychological performance should not be utilized.

Adult↗