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Biomedical subjects

J J Pindborg

Publications and source records attributed to J J Pindborg.

At least 127 records · Page 7Linked to original sources
PubMed1980

Verrucous hyperplasia of the oral mucosa.

Verrucous hyperplasia of the oral mucosa is a relatively unrecognized entity that may resemble verrucous carcinoma clinically and histologically. This study describes the clinical and histological features of the condition, particularly in relation to verrucous carcinoma. Sixty-eight cases were selected by screening all lesions accessioned as verrucous or papillary lesions of various kinds, dysplasias and leukoplakias. More cases occurred in women (56%) than in men (44%). All but 3 patients were 50 yr. or older, and 35% were over 70. Gingiva or alveolar mucosa were involved most frequently (27%), followed by cheek (24%), tongue (17%), floor of mouth and lip (12% each), and palate (8%). Verrucous processes are either sharp and heavily keratinized or blunt with a thin parakeratin layer. In 36 patients (53%), there was associated leukoplakia; in 20 (29%), there was associated verrucous carcinoma; in 45 (66%), associated epithelial dysplasia; and in 7, (10%) there was associated squamous carcinoma. Verrucous carcinoma or squamous carcinoma. Verrucous hyperplasia is best distinguished from verrucous carcinoma in biopsies taken at the margins of the lesions. In the former, the verrucous processes and the greater part of the hyperplastic epithelium are superficial to adjacent normal epithelium. In the latter, the verrucous processes are superficial, but the broad rete processes extend considerably deeper than adjacent normal epithelium, often pulling a margin of normal epithelium down with them into the underlying connective tissue.

Adult↗
PubMed1980

Tobacco-induced changes in oral leukoplakic epithelium.

A study of 112 biopsy specimens from Danish oral leukoplakia patients and 145 biopsy specimens from Indian leukoplakia patients revealed a chevron-like keratinization of the epithelium in a number of cases. Clinically, this type of keratinization was often characterized by a pumice-like appearance. The clinical and histologic changes were only observed in tobacco users, and appeared to be associated particularly with use of pipes, snuff, and hooklis.

Adolescent↗
PubMed1980

Granulomatous gingival manifestations of Melkersson-Rosenthal syndrome.

Of thirty patients with complete or incomplete forms of Melkersson-Rosenthal syndrome, five patients with gingival lesions that microscopically showed the characteristic granulomatous changes are presented, with special reference to their gingival manifestations. In some cases bluish red, small, distinct, and irregular edematous swellings characterized the gingival changes, while in other cases more extensive and diffuse, edematous swellings dominated. All five patients had only vague symptoms from the gingiva. Because of the apparent slowly progressing nature of the gingival swellings and occasional spontaneous regression of the gingival changes, a conservative attitude in the treatment of gingival lesions in MRS is recommended. Gingival symptoms may be the first manifestation of the disease, and it is emphasized that, with an increased diagnostic awareness, gingival involvement may be found more commonly in patients with MRS.

Adolescent↗
PubMed1980

Incidence and early forms of oral submucous fibrosis.

The yearly incidence of submucous fibrosis per 100,000 person-years was found to be 9 for males and 20 for females over a 10-year period in the Ernakulam district of Kerala, South India. In the same area possible early case of submucous fibrosis, under the clinical diagnosis of leukoplakia and lichen planus, showed the typical histologic features of the disease.

Adolescent↗
PubMed1980

An oral lichen planus-like lesion in Indian betel-tobacco chewers.

During an epidemiologic study of oral cancer and precancerous lesions among Indian villagers, a lichen planus-like lesion was observed in Kerala. The lesion consisted of white, wavy, parallel, non-elevated lines that could not be scraped off. The lesion occurred exclusively among chewers and at the site of placement of quid. There were no subjective symptoms. The peak prevalence of the 35 diagnosed lesions was in the 35-44 years age-group for males and 45-54 for females. There was a marked female predominance. The histologic features were very similar to those seen in oral lichen planus.

Adolescent↗
PubMed1979

Clinical and histologic studies on electrogalvanically induced oral white lesions.

Among 1,128 patients with oral leukoplakia and 326 patients with oral lichen planus included in long-term follow-up studies, thirty-two patients showed lesions of the oral mucosa which could be attributed to electrogalvanism. The material consisted of twenty female and twelve male patients. The clinical diagnosis was leukoplakia in sixteen patients and oral lichen planus in the remaining sixteen patients. Histopathologic characteristics were analyzed and correlated to the clinical findings. In five cases malignant transformation developed. The term electrogalvanic white lesions is suggested as a common denominator for these mucosal changes, which seem to take the shape of lichen planus as often as that of leukoplakia.

Adult↗
PubMed1979

Follow-up study of 14 oral granular cell tumors.

The granular cell tumor is an uncommon benign lesion with a predilection for the oral cavity. Fourteen tumors from 13 patients have been reviewed with a follow-up period ranging from 7 months to 21 years with an average of 7.1 years. Women were affected twice as often as men, and the age of the patients varied from 14 to 75 years. Eleven of the lesions were located on the tongue, the remaining on the lower lip, sublingual papilla, and the buccal mucosa. Multiple lesions were found in one patient.The tumors varied in size from 3 to 25 mm in diameter and were all firm to hard in consistency. All the lesions were treated by local excision. Pseudoepitheliomatous hyperplasia of the overlying epithelium was seen in four patients. In spite of a possible inadequate removal of 10 of the lesions where granular cells extended to the margin of excision, no recurrence was seen. A simple but deep local excision is the recommended treatment.

Adolescent↗
PubMed1979

Erythroplakic lesions in relation to oral lichen planus.

In a cohort of 740 referred patients with oral lichen planus eight patients were found with a sharply demarcated slightly depressed erythroplakic area. The histological examination of the biopsies from the erythroplakic lesion of the 8 patients showed seven with epithelial dysplasia. In addition, two of the lesions revealed a squamous cell carcinoma. In the erythroplakic lesion without dysplasia the histological picture was found to be characteristic of lichen planus. All eight patients were seen at later follow-up examinations (median observation period: 3.6 years) and in one patient a squamous cell carcinoma arose in the erythroplakic lesion during the control period. It is concluded that the reported erythroplakic lesions in relation to oral lichen planus seem to be premalignant and they should be followed and/or treated like oral erythroplakias.

Aged↗
PubMed1979

Incidence rate of oral lichen planus among Indian villagers.

In a house-to-house survey in South India, comprising 10,000 villagers, the age-adjusted incidence rate per 1,000 person-years for oral lichen planus was found to be 2.1 for males and 2.5 for females, based upon a 10-year follow-up study. The highest incidence was in the age group 55-64 for males and 45-54 for females. The age-adjusted relative risk was higher for the 'chewing habits' group (6.2) than for the 'smoking habit' group (2.2). The combined effect of the two habits appeared to be multiplicative; the age-adjusted relative risk for the mixed habit group being 13.7.

Adolescent↗