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Biomedical subjects

J J Murphy

Publications and source records attributed to J J Murphy.

At least 127 records · Page 7Linked to original sources
PubMed1985

Simultaneous flow cytometric deoxyribonucleic acid and acid phosphatase analysis of benign and malignant lesions of the prostate.

Flow cytometry can differentiate benign from malignant lesions of the prostate through deoxyribonucleic acid distribution analysis. A method has been developed that permits simultaneous cytometric determination of deoxyribonucleic acid and acid phosphatase activity in the cell cycle compartments of prostatic biopsy specimens. Histograms of prostatic carcinoma reveal higher acid phosphatase activity and greater deoxyribonucleic acid content in the S and S + G2/M populations than the histograms representing benign lesions. This compartmental difference may have prognostic usefulness.

Acid Phosphatase↗
PubMed1984

Percutaneous drainage of pancreatic pseudocysts.

Ultrasonography was used to diagnose, localize and direct the percutaneous transabdominal needle aspiration of 10 pancreatic pseudocysts in 9 patients. Thirty-four aspirations were performed without complication. In 9 pseudocysts no other treatment was necessary, and in all patients relief of pain or obstructive symptoms when present was obtained. None of the cysts have recurred with a mean follow-up of 26 months.

Adult↗
PubMed1984

Torsade de pointes induced by N-acetylprocainamide.

N-Acetylprocainamide (NAPA), a class III antiarrhythmic drug, caused torsade de pointes in a 72 year old woman who had this arrhythmia on two previous occasions while being treated with quinidine and disopyramide. Initial evaluation with an intravenous infusion of NAPA indicated a favorable antiarrhythmic response. The QTC interval was prolonged, but the 2.4 ms/microgram per ml incremental QTC interval lengthening caused by NAPA was not greater than usual. During subsequent oral therapy with NAPA, torsade de pointes developed at plasma levels of this drug that appeared to be well tolerated during the initial evaluation.

Acecainide↗
PubMed1982

Role of immunoglobulin classes in experimental histoplasmosis in bats.

Pooled normal bat serum was separated by gel filtration to give fractions rich in IgG-, Iga- and IgM-like proteins. These fractions were analogous to the corresponding human immunoglobulin classes by immunoelectrophoresis and SDS-polyacrylamide gel electrophoresis. Rabbits were immunized with the fractions and the antisera absorbed. Neotropical bats (Artibeus lituratus) were infected with Histoplasma capsulatum and serum samples were collected weekly and tested for specific serologic response to the fungus. A radial immunodiffusion test was devised to monitor changes in concentrations of IgG, IgA and IgM in the same sera. Bats infected with a low dose of fungus had significantly increased levels of IgM and IgA between 2-6 weeks post-infection. Bats receiving a high dose maintained elevated levels of IgM and IgA through the end of the study. Significantly elevated levels of IgG were not detected until late in the disease (8-9 weeks). In bats with histoplasmosis, IgM and IgA appeared to contribute primarily to the early positive serologies, while precipitating antibodies of the IgG class were detectable later in the disease. These results are similar to the serologic profile seen in human histoplasmosis, and extend our understanding of comparative immune responses in an important wildlife reservoir of human mycotic pathogens.

Animals↗
PubMed1980

Pancreatic pseudocyst: management by ultrasonically guided aspiration.

Five pancreatic pseudocysts were managed by percutaneous transabdominal needle aspiration under ultrasound guidance. Thirteen aspirations were performed without complication. In four cysts this was the sole treatment required. None of these cysts have recurred, with a follow-up of between 6 and 12 months. Surgery of acute pseudocysts can be postponed or eliminated by this technique. Relief of pain and of obstructive symptoms can be obtained and time gained, when necessary, for maturation of the cyst wall.

Adult↗
PubMed1980

Omental transposition as an aid in genitourinary reconstructive procedures.

Mobilization of an intact omental pedicle graft for supportive use has been carried out in a variety of genitourinary reconstructive procedures. Mobilzation is accomplished by detachment of the omentum from the transverse colon and by separation from the greater curvature of the stomach. The right gastroepiploic artery is generally preserved as the blood supply to the omental pedicle. Further pedicle lengthening can be achieved as necessary by selective division of the omentum, based on the arterial anatomy. The rich vascular and lymphatic supply of the omentum and its attendant potential to contribute to healing, even in the presence of infection, while maintaining its suppleness and allowing epithelization to occur over its surface, makes the omental pedicle graft an extremely useful adjunct in the following difficult situations: complicated vesicovaginal, prostatorectal, and rectovaginal fistulas; reconstruction of the bladder neck and bulbo-membranous urethral areas; extensive injury to the bladder; and a variety of renal and ureteral reconstructive procedures.

Female↗
PubMed1980

Repair of vesicovaginal fistula by a suprapubic transvesical approach.

Thirty-four vesicovaginal fistulas of various causes were repaired using a suprapubic, transvesical approach modified after the original technique of O'Connor. Only four failures resulted. Two of the failures were attributed to residual or recurrent carcinoma and two to poor tissue healing resulting from an inadequate delay between the initial surgical procedure and an attempt at reconstructive surgery. Surgical complications included three wound infections and one instance of severe gastrointestinal bleeding. Technical considerations thought to be important include excision of all diseased tissue in the bladder and vagina; complete separation of the bladder from the vagina with a margin of healthy tissue in all directions; careful, watertight closure of both bladder and vagina without tension; interposition of peritoneum or omentum between the closed bladder and vagina, and initial postoperative maintenance of an uninfected and dry suture line.

Evaluation Studies as Topic↗
PubMed1979

The management of some special problems with renal neoplasm.

Simultaneous bilateral renal cell carcinoma has been treated in 5 patients at our hospital during the last 6 years. Improvements in radiologic diagnostic techniques are responsible for the increased detection of these lesions. Results of surgical management are reported. Angiographic embolization of renal cell carcinoma has proved to be a useful method to manage patients with solitary kidneys or those with severe medical problems contraindicating an operation, and our results with this approach are described.

Adenocarcinoma↗