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Biomedical subjects

J J Merland

Publications and source records attributed to J J Merland.

At least 199 records · Page 11Linked to original sources

Arteriovenous malformations (AVM) of the spinal cord in children. A review of 38 cases.

The cases of 38 children with AVM seen at the Lariboisière Hospital since 1962 are reviewed. The clinical picture was often of sudden onset with impairment of motor function and/or subarachnoid hemorrhage. The diagnosis was usually made by myelography, but spinal arteriography is the key examination, since it confirms the diagnosis and is essential to determine the exact location of the angioma: whether it is extramedullary, intramedullary, or mixed. Angiotomography and angiomyelography with magnification are necessary to determine if the lesion is median, compact, and if it has long sulco-commissural arteries, details which have an important bearing on the prognosis. Operation should be performed as soon as possible after its feasibility has been demonstrated angiographically. But embolization with new materials has also been effective, either associated with operation or as an alternative.

Adolescent↗

Vascular malformations of the mandible (intraosseous haemangiomas). The importance of preoperative embolization. A study of 9 cases.

Haemangiomas of the mandible are relatively rare arteriovenous malformations: 85 cases have been described since 1849. The severe risk of bleeding during tooth extraction or biopsy led us to describe the radiological and angiographic features of this condition. The afferent vessels are the inferior dental, the lingual, and the facial arteries. Preoperative embolization reduces the risk of bleeding at operation. Surgical treatment must assure the complete removal of the lesion. Radiotherapy and vascular ligatures are useless and dangerous.

Adolescent↗

[Hemostatic embolization. A report on 212 cases (author's transl)].

Among 1200 patients who have undergone embolization procedure in Lariboisière Hospital, 212 were treated to achieve hemostasis. The topographical repartition shows a preeminence in the cervico-cephalic area (91 cas) but also that hemorrages can now be controlled by this method in any part of the body. Regarding the type of the hemorrages, one must distinguish acute or semi-acute bleedings (52 cases) where embolization may instantaneously stop the hemorrage and spare arterial ligation. Pre-operative embolization (48 cases) allows surgeons to operate under excellent conditions in case of highly vascular lesions. Chronic bleedings (112 cases) affords great relief to the patient while often providing a life saving solution, when other therapeutic have failed.

Acute Disease↗

[Haemostatic embolization: possibilities and prospects. 190 cases (author's transl)].

Among more than 1 100 embolizations performed by one team, 190 were for haemostatic purposes. Owing to the ever increasing availability of suitable material and trained operators, no vascular territory nowadays is unaccessible to the technique. Simultaneous identification of the lesions and control of bleeding are advantages which no longer need be demonstrated. It must be noted that haemostatic embolization can and should be used in debilitated patients with acute or chronic lesions, even in the presence of disseminated intravascular coagulation.

Embolization, Therapeutic↗

Therapeutic angiography in neuroradiology. Classical data, recent advances and perspectives.

This report summarizes the extraordinary development of the neuroradiological entrance into the treatment of massive vascular malformations of the head and spine, also highly vascularized tumors, by embolization accomplished with the appropriate type of catheter and highly refined technique, in collaboration with the surgeons of neurology, ophthalmology, otolaryngology, and of the vascular system.

Adult↗

Closed-chest myocardial ischaemia in dog.

Myocardial ischaemia in dog was induced with releasable material in the distal segment of the anterior descending branch of the left coronary artery. Three releasable materials were tested: gel foam, wax microspheres (120-200 micron) and latex balloons, using different methods of introduction. The left carotid route was selected for introduction of a preformed catheter. The gel foam and wax microspheres caused transitory ischaemia, which was proximal for the foam and distal for the microspheres. The balloons made it possible to standardize the ischaemia as its localization and duration could be selected. This material therefore provided a model for stable chronic ischaemia. Nine dogs were observed by means of precordial mapping (36 electrodes) during the phase following ischaemia or for a period of 4 weeks. The results of these experiments are analysed and correlated with histological results for the post-mortem phase.

Animals↗

[Therapeutic embolization for traumatic renal haemorrhage. 11 cases (author's transl)].

Therapeutic embolization by means of autologous clots or fragments of gelatin sponge was carried out in 11 patients suffering from renal haemorrhage of traumatic origin (5 needle biopsies, 3 surgical operations, 2 external traumas, 1 penetrating wound). Arterio-venous fistulae were present in 6 cases and arterial lesions in 5. Performed with a fine catheter, embolization was highly selective for the segmental arteries involved. The clinical symptoms disappeared within less than 12 hours in three patients, within 2 to 4 days in five and within 15 days in one. In two patients haematuria was only temporarily arrested ; a second embolization could be performed in one of these, but nephrectomy was required in the other.

Adolescent↗