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Biomedical subjects

J J Bubis

Publications and source records attributed to J J Bubis.

At least 55 records · Page 3Linked to original sources
PubMed1976

Experimental cerebral ischemia in Mongolian gerbils. v. Ultrastructural changes in H3 sector of the hippocampus.

Mongolian gerbils exposed to relatively short (7 or 15 min) unilateral or bilateral occlusions of the common carotid artery develop, 20 h after release of the clipping, characteristic morphologic changes in the H3 sector of the hippocampus. Ultrastructural study of these changes revealed an eccentric shift of the nuclei associated with chromatolytic perikarya which showed a dense accumulation of lysosomes and mitochondria in their central parts. The Golgi apparatus was recognizable only by clusters of vesicles, and this change was associated with a negative thiamine pyrophosphatase reaction.

Animals↗
PubMed1976

Acinic cell tumor of the bronchus.

A bronchogenic tumor was removed from a 12-year-old girl. Histology showed a clear cell lesion with electron microscope features compatible with serous acinic cell origin.

Bronchial Neoplasms↗
PubMed1975

Myeloid bodies formation in triparanol treated cultured cells.

Cultured cells (chicken embryo liver cells and rat embryo fibroblasts) were treated with triparanol (MER-29) for various lengths of time. Both types of cells have developed numerous membranous whorls-myeloid bodies in the cytoplasm. Various stages in myeloid bodies development are described. Acid phosphatase activity was cytochemically demonstrated within the myeloid bodies, indicating their lysosmal nature. This activity appeared only at a late stage of the myeloid bodies formation.

Acid Phosphatase↗
PubMed1975

Oxidation of lipids and membranes II: Effects of oxidants on cerebral white matter homogenates.

Bovine cerebral white matter homogenates were oxidized by various oxidizing solutions of equal molarity and subsequently extracted with water. Most of the oxidants tested (K-dichromate, FeCL3, H2O2, O2, and chloroperbenzoic, ascorbic, performic, and periodic acids) rendered the various myelin constituents less extractable than the constituents of unoxidized control homogenates. KMnO4, and to a lesser degree hemoglobin, rendered myelin constituents more extractable with water than those of the control homogenates. The findings indicate that most of the oxidants produced stabilization of the lamellar pattern, probably through cross-linking and polymerization. KMnO4 and hemoglobin caused labilization and breakdown of the membranous structure. Proof that stabilization of membranes is caused by some oxidants and that fragmentation occurs by the action of KMnO4 and hemoglobin was obtained by the light scattering technique and by electron microscopy of the oxidized homogenates. Evidence obtained indicated that formation of hydrophobic end groups during oxidation favors polymerization, while prevalence of hydrophilic groups is associated with fragmentation.

Animals↗
PubMed1975

Ultrastructural study of focal epithelial hyperplasia.

Biopsy material from two young Israeli patients with focal epithelial hyperplasia revealed acanthosis, papillomatosis, and the presence of many epithelial cells with a clear cytoplasm in the basale and stratum spinosum. Many of the inclusions seen with the electron microscope had the morphologic appearance of lysosomes, but definite identification must await cytochemical evidence.

Adolescent↗
PubMed1975

Storage of polyvinylpyrrolidone mimicking a congenital mucolipid storage disease in a patient with Munchausen's syndrome.

A 24-year-old woman from the Sinai peninsula had, since the age of 15 years, repeatedly undergone surgery because of gastrointestinal bleeding. The bleeding was found to have been caused by self-inflicted injuries. Histiocytes in the patient's liver and lymph nodes (the spleen had been removed nine years previously) contained a peculiar material which was, in part, basophilic and had puzzling histochemical characteristics. The material is believed to be polyvinylpyrrolidone (PVP), which had been administered to the patient during one of her operations. The importance of recognizing this change, especially in countries where PVP is administered as a plasma expander, is stressed.

Adult↗
PubMed1975

Acid esterase in the aorta of the hyperlipidemic rat: a histochemical study.

In rats maintained for about three weeks on a diet inducing hyperlipidemia E-600 resistant acid esterase activities were markedly reduced in the aorta in comparison with untreated animals. In rats which were maintained on an ordinary diet containing the same amount of thiouracil as given to the hyperlipidemic animals, only a slight reduction of acid esterase activities was noted. Another group of animals was fed an ordinary diet for three weeks after three weeks on a hyperlipidemic diet. In the aorta of these animals the acid esterase activities were almost normal. There was little fat deposition in the aortas of animals given the various diets. No such effects on esterase activities were observed in the liver and lung of animals of the various groups. Inhibition of acid esterase activity was also observed in rats kept on a hyperlipidemic diet for 65 days. In these animals patchy deposition of partly anisotropic lipid was observed in the intima and media.

Acid Phosphatase↗
PubMed1972

Subacute spongiform encephalopathy and its relation to Jakob-Creutzfeldt disease: report on six cases.

An account is given of six cases of Jakob-Creutzfeldt disease confirmed at necropsy. The rapid fatal outcome within three months was typical of the variety designated subacute spongiform encephalopathy (Nevin-Jones). The characteristic EEG changes were found to be of great value in making an early diagnosis and, together with akinetic mutism and myoclonus, constituted an easily recognizable picture. Treatment with idoxyuridine was ineffective in one case in which electronmicroscopy of brain biopsy material supported the diagnosis.

Adult↗
PubMed1972

Subacute spongiform encephalopathy. Electron microscopic studies.

Electron microscopic changes in brain biopsies from two cases of subacute spongiform encephalopathy are described. Large vacuoles seen in astrocytic and neuronal processes were surrounded by one or more concentric membranes. Dense-core vesicles were found in axonal endings and in nerve cell perikarya; these particles could represent catecholamine-containing vesicles.

Brain↗