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Biomedical subjects

J Inoue

Publications and source records attributed to J Inoue.

At least 253 records · Page 14Linked to original sources
PubMed1982

Therapeutic effects of tiopronin on chronic hepatitis: a double-blind clinical study.

The efficacy of tiopronin (2-mercaptopropionyl glycine) 600 mg daily in the treatment of chronic active or chronic persistent hepatitis has been assessed in a double-blind controlled clinical trial of 12 weeks involving 165 Japanese patients with histologically proven disease. Treatment with the drug was associated with a significant improvement in abnormalities of serum transaminase and gamma glutamyl transpeptidase, with reversion towards baseline values on stopping the drug. Improvement was independent of the histological classification of the disease, or HBsAg status. The drug was well tolerated with few side-effects. The results of this short-term study indicate that tiopronin may be of value in the treatment of chronic hepatitis.

Acyltransferases↗
PubMed1982

Superior and inferior vena cava flow velocity in patients with anomalous pulmonary vein connection.

The superior and inferior vena cava flow velocities (SVC and IVC flow velocities) of 3 patients with anomalous pulmonary vein connection were recorded with the Doppler flowmeter catheter. The cases consisted of a patient with partial anomalous pulmonary vein connection to the SVC (Case 1), one with total anomalous pulmonary venous connection to the SVC (Case 2), and one with partial anomalous pulmonary vein connection to the IVC (Case 3). The SVC and IVC recordings of these patients were compared with those of 10 normal subjects, 20 patients with atrial septal defect and 150 patients with other heart diseases. The SVC and IVC flow velocities in the latter group of 180 patients showed a biphasic pattern, having systolic (S) and diastolic (D) waves, the peak S wave occurring around midsystole. In Cases 1 and 2, the SVC flow velocity showed a markedly delayed peak S wave, similar to the pattern of the pulmonary vein flow velocity; this pattern was also seen in the IVC flow velocity in Case 3. This abnormal pattern could be useful in diagnosing anomalous pulmonary vein connection.

Adolescent↗
PubMed1981

Infection of group A streptococcus and antibody response to extracellular antigens.

A study demonstrating the relationship between pharyngeal infection of group A streptococci and the antibody response was performed. Group A streptococci were recovered from 44 (9.4%) of 466 children, of which 41 strains were typable by T-protein. Fifty-five percent of 41 children from whom group A streptococci were recovered showed a significant rise in anti-streptolysin O (ASO) titers in sera. In children from whom group A streptococci were recovered and with elevated ASO titers, titers of antideoxyribonuclease B (ADNase B) were significantly higher than those who were negative for group A streptococci and also showed elevated or normal titers for ASO. Patients with acute rheumatic fever demonstrated elevated titers of both ASO and ADNase B. These findings suggest that a combination of ASO and ADNase B titers should be applied to diagnose the streptococcal infections. Antinicotinamideadenine dinucleotidase showed a low level of titers in children who had group A streptococci in their throat and exhibited elevated titers in streptococcal antibodies, and also in patients with acute rheumatic fever.

Adolescent↗
PubMed1980

The movement of streptococcal infection in Otsu City.

The throat cultures were collected on swabs from total number of 3,599 of first grade children of elementary schools in Otsu City in 1978. Beta-hemolytic streptococci were isolated from 628 of 3,599 children (17.4%). Group A strains were found in 403 of 628 children (64.2%). Thus the frequency of recovery of group A streptococci from the children was 11.2% in this study. The size of tonsils in children with positive cultures for group A streptococci and negative response of ASO was larger than tonsils of children with negative cultures for group a strains and negative ASO response, and were smaller than the tonsils of children with positive cultures for group A strains and with positive ASO response. On the 20th day after oral administration of 400,000 units of penicillin derivative, group A strains were eradicated from throats in 76.2% of the treated children.

Antistreptolysin↗
PubMed1980

Detection and characterization of circulating immune complexes during acute exacerbation of chronic viral hepatitis.

For the detection and characterization of circulating immune complexes (CIC) in various liver diseases, a Clq binding test was used. Though the CIC level was almost normal in HB surface antigen (HBsAg) positive asymptomatic carriers, the level increased in patients with liver diseases. During acute exacerbation of chronic viral hepatitis, the CIC level reached peaks 1 to 3 weeks before and after the hepatic cell necrosis. Study of the sedimentation rates of CIC in various liver diseases showed CIC in the 19s-22s region and in the 7s-19s region. In acid buffer, CIC was dissociated into 5 to 6 components by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). In one case of HBsAg positive severe chronic aggressive hepatitis, CIC was composed of HBsAg, IgG and another three or four undetermined components. During acute exacerbation of chronic hepatitis, minor changes of these dissociation patterns of CIC were observed.

Adult↗
PubMed1980

Tissue immune complexes demonstrated in the liver of patients with chronic aggressive hepatitis using FITC-labelled human Clq.

Immune complexes in liver specimens from 10 patients with chronic liver diseases [2 with chronic persistent hepatitis (CPH), 3 with chronic aggressive hepatitis (CAH) of moderate activity, 3 with CAH of severe activity, and 2 with liver cirrhosis] were examined by a technique of direct immunofluorescence using FITC-labelled human purified Clq (FITC-Clq). FITC-Clq bound to the nuclei of all cells in liver tissue. After DNase treatment, positive nuclei were absent, but positive staining with FITC-Clq remained in amorphous deposits and hepatic cell membranes in the areas of piecemeal necrosis of four CAH patients. Since FITC-Clq could not be demonstrated in the liver tissue of CPH and liver cirrhosis which contained no piecemeal necrosis, positive fluorescence in the liver of CAH patients was thought to indicate immune complexes bound to FITC-Clq. The fact that these positive substances, however, were few in number, may be the result of physiological mechanisms of immune clearance which rapidly eliminate immune complexes from the body.

Antigen-Antibody Complex↗
PubMed1980

Detection of tissue T-cell in patients with chronic active hepatitis using fragmented sheep red blood cell (SRBC) membrane.

Fragmented sheep red blood cell (SRBC) membrane was used for detection of T-cells in liver biopsy specimens from patients with chronic active hepatitis. SRBC was separated with Lymphoprep, sonicated, then filtered through a 3 mu Millipore-membrane as a fragmented SRBC reagent. Tissue T-cells were stained by an indirect immunofluorescent technique using SRBC reagent and fluorescein isothiocyanate (FITC)-labelled rabbit anti-SRBC. Positively staining lymphocytes were present in portal tracts and in areas of piecemeal necrosis. There also seemed to be a positive correlation between the number of positively staining lymphocytes and the activity of chronic hepatitis; numerous lymphocytes being stained in areas of severe piecemeal necrosis. Our findings suggest that the fragmented SRBC technique for detection of T-cells is reliable and reproducible, that it could be used as a clinical routine method, and that it is useful for further elucidating the nature of host immune reactions on tissue levels.

Adult↗
PubMed1980

Follow-up ten years after corticosteroid therapy for chronic active hepatitis type B.

Follow-up studies were conducted on chronic liver disease patients treated 10 years previously with corticosteroid (CS), Hbs antigen (HbsAg) was measured in previously collected paraffin embedded liver sections by enzyme-labelled antibody technique. Of 57 cases examined, 38 cases were treated with CS or immunosuppressive agents and 19 cases were not treated with CS (control group). -- Two deaths occurred in the CS-treated group and 4 in the non-CS treated group. These patients were diagnosed as either the 2B type (severe activity) of chronic aggressive hepatitis (CAH) or as having liver cirrhosis. One death was found in the 10th year due to hepatocellular carcinoma in a chronic persistent hepatitis (CPH) patient with HBsAg diffusely distributed in liver tissue. No significant difference was found in the rehabilitation rate in HBsAg negative cases of the CS group versus the control group. In positive cases, the rehabilitation rate was found to be 66.7% in the CS group compared with 0% in the non-CS group.

Adrenal Cortex Hormones↗
PubMed1980

Further studies on gangliosides of erythrocytes from horses and cattle.

The ganglioside patterns of erythrocytes from individual horses and cattle were examined. Variations in the ganglioside patterns were found in both horses and cattle. In the erythrocytes of most horses examined, NeuGc-Gal-Glc-ceramide (NeuGc-GM3) of 25 horses examined had only NeuGc-GM3 with no 4-O-Ac-NeuGc-GM3. The erythrocytes of various breeds of cattle had a characteristic ganglioside pattern, but they could be divided into 4 types on the basis of the composition of their gangliosides.

Animals↗
PubMed1979

Occurrence of hematoside with two moles of N-acetyl-neuraminic acid in a certain breed of Persian cat.

The glycolipids of erythrocytes from individual cats were examined. The main glycolipid of cat erythrocytes was generally NeuGc-NeuGc-Gal-Glc-ceramide (NeuGc-GD3), but among 41 cats of 5 breeds and 2 mongrels examined, 2 Persian cats were found to have NeuAc-NeuAc-Gal-Glc-ceramide (NeuAc-GD3). This is the first report of the occurrence of NeuAc-GD3 in cat erythrocyte membranes.

Animals↗