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Biomedical subjects

J Huber

Publications and source records attributed to J Huber.

At least 271 records · Page 15Linked to original sources
PubMed1981

[Postpartal serum bilirubin levels in the newborn after induction of labour with "prostaglandin cap" or oxytocin (author's transl)].

In the course of a prospective study the development of Serum bilirubine levels was controlled in 90 neonates. In 30 cases labour had been induced by means of intravenous oxytocin infusion, in a further 30 cases by means of local peri-cervical prostaglandine E2 (PGE2)-application. The control group consisted of 30 children, with spontaneous onset of labour. Anamnesis, duration of gravidity, course of labour and method of delivery were the same in all groups; the neonates were all treated the same. The serum bilirubine was determined fotometrically with the Greiner Selective Analyzer GSA II on the 1st, 3rd and 5th post partum day and the results assessed by the multivariant analysis according to Newman-Keuls. No differences were found between the PGE2- and the control group, the bilirubine values of the oxytocin groups were significantly higher (p less than 0.001). Icteric neonates with serum bilirubine values of greater than 12 mg% were found more than double as often in the oxytocin group than in the PGE2- group (7:3). The results indicate, that for labour induction by pharmaceuticals, local application of PGE2 by means of a portio cap should be favored over intravenous oxytocin administration.

Bilirubin↗
PubMed1980

[Death caused by ill-fitting dentures].

Two deaths afford evidence of the fact that ill-fitting dental prostheses may have fatal consequences. These may arise from swallowing the wrong way, aspiration or distorsion of the pharyngeal mucosa, especially where the patient's consciousness is somehow impaired and above all under the influence of alcohol. Both of the deaths under consideration could have been avoided by adequate correction of a dental prosthesis. Patients with defective or ill-fitting prostheses should be made aware of the dangers and referred to a dentist.

Adult↗
PubMed1980

In vivo and in vitro effects of lithium on granulopoiesis in human neutropenic disorders.

Studies have been cazrried out to determine the in vivo and in vitro effects of lithium carbonate in various neutropenic disorders. Addition of lithium to culture of bone marrow from patients with a variety of neutropenic disorders and ANLL in which normal or elevated serum and/or urinary CSA levels were present did not enhance granulocyte colony formation. Administration of lithium carbonate to patients with Felty's syndrome, in which serum and urinary CSA levels are reduced, enhanced peripheral blood neutrophil levels and serum and urinary CSA values. Lithium administration appears to be most beneficial in neutropenic patients in whom it can be demonstrated that CSA production is reduced.

Acute Disease↗
PubMed1980

[Ten-year record of surgical treatment of gynaecological carcinomas at Kaiser-Franz-Josef Hospital (author's transl)].

Brief reference to surgical techniques applied to carcinomas of the cervix, corpus, and ovaries is followed by a comprehensive report in greater detail on carcinoma patients treated between 1969 and 1978. Mention is made first of carcinoma of the cervix, with particular reference being made to its preliminary phases, including basal hyperplasia, dysplasia, carcinoma in situ, and microcarcinoma. No patients in preliminary phases at all had been admitted to hospital in 1969, but almost 100 patients per annum were hospitalised more recently, in the wake of extended routine testing, including colposcopy, Papanicolaou's diagnosis, and checks by reflected light. The total number of patients admitted over the ten years under review has been 476, with carcinomas being detected in most of them by conisation. Wertheim's radical surgery with lymph node exstirpation was applied to 221 cases of invasive carcinoma of the cervix. Hysterectomy, with both adnexa involved, and lymph node exstirpation were applied to 154 cases of corpus carcinoma. The uterus only, but usually together with the adnexa, was removed in 19 cases. Surgery was applied to 109 cases of ovarian carcinoma, with adnexa being removed, in some cases with hysterectomy and omentumectomy. Also admitted were 17 patients with different types of carcinomas and eleven cases of uterus sarcoma. Surgical treatment was given to 984 of 1,130 genital carcinomas, bringing the overall operability rate to 87 per cent. Primary therapeutic irradiation was decided for most of the other patients. Ther overall mortality was 1.6 per cent (16 cases).

Austria↗
PubMed1980

[Perioperative metronidazole-prophylaxis for cesarian section (author's transl].

A prospective, randomized clinical trial was conducted in 103 patients undergoing cesarian section to assess the efficacy of prophylactic, intravenously administered Metronidazole on the infectious morbidity. A group of 53 patients with perioperative Metronidazol-prophylaxis was compared to a similar controll-group without prophylaxis. Bacteriologic swabs were taken from the cervix pre- and postoperatively, using anaerobic transport media. Prophylactic Metronidazole reduced postoperative fever of more than 38 degrees C on two subsequent days from 60% in the controll-group to 30,2% in the Metronidazole-group (p less than 0,01) wound infections were reduced from 18% without to 5,7% with prophylaxis (p less than 0,05) and Endometritis from 30% without to 13,2% with prophylaxis (p less than 0,05). An additional antibiotic therapy was necessary in 44% of the cases in the controllgroup, compared to 24,5% of the cases in the Metronidazolegroup (p less than 0,05). The mean duration of hospitalisation was reduced from 12,1 +/- 3,2 days in the controll-group to 11,2 +/- 2,1 in the Metronidazole-group (p less than 0,01). Anaerobic bacteria were isolated from the servical swabs in 60% preoperatively, with a still increasing incidence to 72% postoperatively, compared to 7% in the Metronidazole-group. Our results suggest, that prophylactic, intravenously administered Metronidazol reduces the infectious morbidity following cesarian section due to the reduction of the anaerobic flora at the female genital-tract.

Adult↗
PubMed1980

[Local application of prostaglandins by means of a portio-adapter: A new method of induction of labor (author's transl)].

In 102 pregnant women with low cervix-scores (37th-42nd week of gestation) 1,25 mg PGE2 were applied to the cervix uteri by means of a portio-adapter. In 69 cases (67,6%) labor was induced. In 7 cases additional 0,75 mg PGE2 were instilled after 6h. in 9 women the portio-adapter was applied a second time the next day (in 4 of these even a third time). In 17 cases amniotomy was performed the next day. 11 patients (10,8%) were delivered by Cesarian section or low forceps, one women was discharged from hospital, all other delivered spontaneously. In 15 consecutive spontanous deliveries the pH of the V. umbilicalis was 7,29 +/- 0,12, the arterial pH 7,23 +/- 0,15. Intrauterine tocography revealed a uterine hyperactivity with no dystocie. When prostaglandins are applied to the cervix by means of a portio-adapter, the preparation of a gel-mixture can be avoided, an exact anatomic localisation of the therapeutic solutions is provided and the prostaglandins can be withdrawn at least partly in case of hyperstimulation. Another advantage of this from this induction is that the women are not confined to their bed until shortly before delivery.

Administration, Topical↗
PubMed1979

[A study of a swimming training programme in the rehabilitation of patients following myocardial infarction (author's transl)].

A special swimming programme was initiated during the course of rehabilitation of patients after myocardial infarction with additional disturbances of the musculoskeletal system. Allowance was made for aspects of individual training requirements. Patients were divided in two groups according initial values of physical working capacity: One group contained patients with less than 80% of the normal work capacity, the other those with borderline normal values. The first group showed an average increase of 35% in the initial values during a one-year period of swimming training once a week. The other group with practically normal initial values showed only a slight or negligible increase. Serum lipid levels were unchanged in both groups. No serious side effects were encountered in more than 3000 patients hours. However, no prediction of the risks of this type of training as compared to other forms of physical exercise in patients recovering from myocardial infarction can be made from this study.

Adult↗
PubMed1979

Hepatitis B-associated membranous glomerulonephritis in a child.

This appears to be the first reported case of membranous glomerulonephritis in a pediatric asymptomatic carrier of hepatitis B virus in North America. Routine immunofluorescent methods were used to identify the hepatitis B surface antigen in glomeruli. In addition, the glomerular immune deposits were searched for the known ultrastructural forms of the virus.

Biopsy↗
PubMed1979

[ECG changes in adriamycin therapy].

185 electrocardiograms, of a total of 39 patients were analyzed during and after Adriamycin treatment. Total Adriamycin doses did not exceed 70--120 mg in each course, respecting the 550 mg/m2 limit. ECG changes were found in 80% of such therapeutic regimen, changes of heart-rate, PQ, QT-intervals and ST/T predominating, Arrhythmias (supraventricular and ventricular ectopic beats as well as AV-blocks grade I--II) were observed in several patients.

Adolescent↗
PubMed1979

Complement-fixing anti--double-stranded DNA with the Crithidia method: a better indicator of active SLE than anti-DNA with the Farr method.

Twenty-seven patients with SLE of juvenile onset were studies for 2 years. Episodes of active disease and quiescence were defined and were related to levels of anti-dsDNA and C3. Two methods for the detection of anti-dsDNA--the Farr assay and Cr immunofluorescence--were compared. The latter method was also used to differentiate anti-dsDNA according to its Ig class and its CF property. Positive tests for anti-dsDNA and low C3 levels were correlated with activity of the disease. Results with the Farr assay and Cr Ig test were comparable, but both low C3 and Cr CF anti-dsDNA showed a significantly stronger association (p less than 0.001) with active SLE than did DNA binding by the Farr method or Cr Ig anti-dsDNA. Furthermore, in six patients followed during active disease and remission, a negative Cr CF test was the earliest sign of ensuing clinical remission; DNA binding and C3 levels took weeks to months longer to normalize. This predictive value of CF anti-dsDNA may be useful in monitoring therapy for SLE, especially if symptoms due to prior renal damage may be confused with active disease as in lupus nephritis.

Adolescent↗
PubMed1979

Membranoproliferative glomerulonephritis type 1: comparison of natural history in children and adults.

Clinical, laboratory and pathological data on 46 patients (29 children and 17 adult) with Type 1 membranoproliferative glomerulonephritis (MPGN) were reviewed in order to compare the natural history of the disease in two age groups. The nephrotic syndrome was the most common presenting clinical feature in both age groups. Established renal failure at time of biopsy was seen in adult males only. All the adults males, but none of the women, were either dead or in renal failure after a mean duration of diseases of 17.7 months. In contrast 43% of the children (both sexes) were in renal failure after a mean duration of disease of 51.6 months. Statistical analysis disclosed that only up to 48 months was there a significant difference in survival between the two age groups (P less than .01). Beyond this time the difference was not statistically significant. The difference in behaviour of MPGN in the two age groups is similar to that observed in other glomerulonephropathies.

Adolescent↗
PubMed1978

Fatal rotavirus gastroenteritis: an analysis of 21 cases.

During the period of May 1972 to March 1977, twenty-one fatal cases of rotavirus acute gastroenteritis were recorded in the city of Toronto. The mean age of these subjects was approximately 1 year. Boys outnumbered girls by 12 to 9. Death occurred within three days of onset of symptoms in all cases. Sixteen of the subjects were profoundly dehydrated and had sodium levels (serum or vitreous humor) in excess of 150 mEq/liter. In 11 subjects, sodium values were greater than 160 mEq/liter. Although a physician was contacted in 16 instances, these infants still perished. We suggest that both language difficulties and the rapid rate of fluid depletion contributed significantly to the fatal outcome. At autopsy the bowel was often dilated and filled with fluid. Postmortem autolysis precluded an accurate histological assessment of the small bowel mucosa.

Acute Disease↗
PubMed1978

Idiopathic infantile arterial calcification in siblings: radiologic diagnosis and successful treatment.

Idiopathic infantile arterial calcification is a disorder of unknown etiology manifested by widespread arterial calcification. This usually leads to early death from coronary artery occlusion. In 12 of the 75 cases in the literature, radiographs were taken and it was possible to make the diagnosis in them all. We present two patients, siblings, in whom the diagnosis was established radiologically. The nature of the calcium deposits was studied in one of the infants and proved to be calcium hydroxyapatite. Therapy with diphosphonate was apparently successful in the other child.

Arteriosclerosis↗
PubMed1978

Recurrence of the hemolytic uremic syndrome in a 3 1/2-year-old child, 4 months after second renal transplantation.

Terminal renal failure secondary to the hemolytic uremic syndrome (HUS) developed 18 months after initial transplantation and 4 1/2 months after the child received his second cadaveric renal allograft. Recurrence of the syndrome was evidenced by gross hematuria and hypertension after a 'flu-like' illness, sudden decrease in platelet count and hemoglobin, and erythrocyte fragmentation. Renal biopsy findings were compatible with HUS. Evidence is presented that the HUS was a recurrence of the original disease.

Cadaver↗
PubMed1978

Clinical, pathological and genetic aspects of a form of cystic disease of the renal medulla: familial juvenile nephronophthisis (FJN).

A combined clinical, pathological and genetic study of 13 cases of FJN is reported. The clinical features are conistent with those described in the literature, except that short stature is not a feature in this group. Hyperplasia of the juxtaglomerular apparatus has been seen in 5 of 9 cases where histology was done. The genetic studies support the view that FJN is an autosomal recessive hereditary disease. Because their patterns of inheritance differ, FJN and medullary cystic disease (MCD) are separate entities. We suggest simplification of the nomenclature to: medullary cystic disease of childhood type, formerly FJN and medullary cystic disease of adult type, formerly MCD.

Adolescent↗
PubMed1978

Cerebral white matter lesions in sudden infant death syndrome.

In 21.6% of infants who died of sudden infant death syndrome, the cerebral white matter showed areas of leukomalacia. Of those infants with congenital heart disease, 24.8% had lesions, whereas 4.4% of infants who died from known acute causes had lesions. The sites of the cerebral white matter lesions, subcortical or periventricular, seem to be related to the age of the infant.

Age Factors↗