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Biomedical subjects

J Hazard

Publications and source records attributed to J Hazard.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Results of long term use of a low dose estroprogestatif in diabetics and "high risk" women].

The authors study the long term effects (3 to 30 months) on carbohydrate metabolism of an oral contraceptive containing lowdoses of ethinyloestradiol (0.03 mg) and 0.15 mg of dnorgestrel. The study was carried out in 19 women with diabetes and/or high risk - 5 were on insulin, 6 had asymptomatic, latent or potential diabetes and 8 were obeses. In the insulin dependent group, no changes were seen in blood glucose levels. Insulin doses were the same before and during treatment. In the asymptomatic diabetes group, no modification in carbohydrate metabolism occured. Glucose tolerance tests which were abnormal before treatment became normal under treatment. This finding is discussed. In the obese group, carbohydrate tolerance remained normal during treatment. The low dose of ethinyloestradiol in this "pill" is probably responsible for the absence of diabetogenic side-effects. It would thus appear possible to use such an oral contraceptive in diabetics (overt or asymptomatic) when necessary. However the customary regular surveillance is required.

Blood Glucose↗
PubMed1975

[Assay of serum creatine phosphokinase in primary hypothyroidism. Comparison with other thyroid gland function tests in 32 cases. Value of isoenzyme studies].

Serum-creatine phosphokinase levels were measured in 32 cases of primary hypothyroidism in adults and compared with the results of other thyroid function test. C.P.K. elevation appeared to be almost completely uniform (31 out of 32 cases) and marked, reaching six times the normal value. This elevation is more marked in 18 myxoedematous patients than in 14 with those with hypothyroidism of mixed aetiology. Close correlation does not seem to exist between the elevation of C.P.K. and the lowering of serum thyroxine. The elevation of C.P.K. above the upper limits of normal seemed more constant than lengthening of the achilles reflex time, a rise in serum cholesterol, or a rise in other enzymes of muscular origin, such as the glutampopyruvic and glutamo-oxalocetic transaminases, lactodehydrogenase and hydroxybutyric dehydrogenase. In 8 cases of hypothyroidism, the isoenzymic study of serum C.P.K. by electrophoresis on cellulose acetate confirmed that the molecular structure was of the muscle type MM. The advantage of such a study shows that a structure MB found in the case of myocardial infarction in a patient with hypothyroidism deserves to be stressed.

Adolescent↗
PubMed1975

[Hypokalemic quadriplegia revealing Fanconi syndrome and myeloma].

The authors report a case of multiple myeloma presenting in an unusual fashion as a hypokalaemic quadriparesis secondary to a renal proximal tubulopathy. The tubular functional disturbance appeared to be related to the presence of kappa-type light chains. Electron microscopical study demonstrated in the cells of the concoluted tubules abnormalities which apparently constitute the anatomical substratum of this abnormality. Study of tubular function revealed glycosuria, proximal type tubular acidosis and altered reabsorption of phophorus and uric acid.

Acidosis, Renal Tubular↗
PubMed1975

[Comparative action of carbamazepine and clofibrate in diabetes insipidus. Study of 7 cases].

A study was performed on the effects of carbamazepine and of clofibrate in 7 cases of diabetes insipidus of high origin. In 4 cases the action of the two substances used in association was studied. Carbamazepine, in a dose of 0.60 g/day was effective in all cases with negativisation of free water clearance in 5 out of 7. Clofibrate, in a dose of 1.50 g/day was effective in 4 cases out of 7 with negativation of free water clearance in 2. Both medications act by provoking the secretion of anti-diuretic hormone by the hypothalamic/posterior pituitary centres and are thus only active if a minimal secretion of ADH is still possible. There is no apparent potentialisation of the two substances, which both require a minimal possibility of ADH secretion to be active. There is no diminution in the ADH secretor effect, since both products remain active for as long as they are given, making it possible to observe in 3 out of 7 cases spontaneous cure of the diabetes insipidus, allowing suppression of the treatment.

Adolescent↗
PubMed1975

[Disorders of intra-cardiac conduction and hypothyroidism in adults. A systematic study of 42 cases].

The rate of occurrence of disturbances of intracardiac conduction in association with adult hypothyroidism is not well known. On the basis of routine study of the electrocardiograms of 42 non-treated patients, disturbances of conduction were found in almost one third. Left anterior hemiblock (6/42) and first degree atrioventricular block (5/42) are the commonest. Bifascicular involvement is rare. Neither a trifascicular lesion nor complete AV dissociation were seen. There was no evident effect of hormone therapy on conduction disturbances. Their prognosis is good but they should perhaps be taken into consideration when the indications for beta-blockers are weighed.

Adolescent↗