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Biomedical subjects

J Hattingh

Publications and source records attributed to J Hattingh.

At least 55 records · Page 3Linked to original sources
PubMed1982

Effects of heat and cold exposure and exercise on the interstitial fluid proteins of the rat.

1. Interstitial fluid (obtained from capsules implanted subcutaneously) and plasma were obtained from rats before and after heat and cold exposure and exercise. 2. In the case of plasma, cold and heat exposure and exercise decreased A/G ratios. Albumin concentrations also decreased after heat and cold and protein concentration increased after exercise. 3. Cold decreased interstitial protein and albumin concentrations and A/G ratios. Heat exposure increased protein concentration and decreased the A/G ratio. Exercise decreased decreased protein concentrations. 4. The results are discussed in relation to previous findings.

Albumins↗
PubMed1982

Effects of haemorrhage on colloid osmotic pressure in the pigeon.

1. Colloid osmotic pressure, plasma osmolality and plasma protein concentration, percentage composition and A/G ratio were measured before and after haemorrhage in the pigeon. 2. Colloid osmotic pressure, total protein, albumin and beta-globulin concentrations decreased significantly immediately post-haemorrhage, but were significantly elevated after one week. 3. Osmolality and A/G ratio values were significantly increased post-haemorrhage. 4. The results are discussed in relation to fluid exchange across capillaries.

Animals↗
PubMed1979

Precipitation of animal plasma proteins by puff-adder venom.

1. Plasma and serum samples obtained from various animals never previously exposed to snakes or snake venom were diffused against different concentrations of puff-adder, Bitis arietans, venom using the double immunodiffusion technique. 2. Depending upon venom concentration, two precipitin arcs could be produced in the case of all plasma samples used. No serum samples showed any arcs except pigeon serum, where one precipitin line was observed. 3. By altering the concentration of snake venom between 1% and 10% when immunodiffusing against plasma a change in position of the precipitin lines was observed and also the disappearance of one or both of the two bands at higher concentrations. This indicates that the arcs observed are in all probability due to precipitation of plasma protein fractions. 4. Previous results indicated that one of the two bands observed when diffusing venom against plasma was due to the precipitation of fibrinogen. By diffusing snake venom against heparin we have now shown that the second band involves this molecule and is not due to another coagulation factor as was suggested previously.

Animals↗
PubMed1979

Fever induced in rabbits by intravenous injection of bovine serum albumin.

1. Bovine serum albumin injected into conscious rabbits produced a dose-dependent fever of short latency and duration of at least 2 1/2 hr. 2. The fever was not due to contamination by other proteins nor due to contamination by bacterial endotoxin. 3. The fever following albumin injection had characteristics similar to endogenous pyrogen fever. 4. Some traditional ways of distinguishing bacterial endotoxin fever from other types of fever need to be reassessed.

Animals↗
PubMed1978

Cerebrovascular effects of cerebrospinal fluid removal.

The effects on cerebral blood flow of withdrawal of graded volumes of cerebrospinal fluid (CSF) from the cisterna magna were studied in 12 barbiturate-anaesthetized baboons. The results show that withdrawal of CSF was accompanied by a decreased CSF pressure, an increased CSF PCO2, a decreased CSF PO2 and an increased cerebral blood flow. The possible clinical significance of these findings is pointed out.

Animals↗
PubMed1978

Commercial heparin solution investigated in vitro after reported impaired nerve function in a patient.

Exposure to commercial heparin solution caused rapid conduction failure in frog sciatic nerve preparations. The toxic substance was not the heparin itself, but the 0,5% phenol preservative. Phenol solutions with concentrations between 0,1% and 5% caused a dose-dependent nerve failure, which manifested as a progressive decline in compound action potential amplitude. Care must be taken in the administration of any solution preserved with phenol, to prevent nerve damage.

Animals↗