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Biomedical subjects

J Hata

Publications and source records attributed to J Hata.

At least 271 records · Page 15Linked to original sources
PubMed1980

Serum CEA levels in gastrointestinal diseases.

Preoperative carcinoembryonic antigen (CEA) levels in 36 colorectal carcinoma patients were corrected in accordance with pathological stage and tumor location. Increasing levels of CEA were found in advanced stages of the disease. There were no significant differences among the CEA levels of right-sided colon tumors, left-sided tumors and rectal tumors.

Adolescent↗
PubMed1979

Immunopathologic and histologic studies on benign recurrent hematuria. Clinicopathologic similarities with IgA nephropathy.

From a series of 152 renal biopsy specimens examined by light, immunofluorescence, and electron microscopy, nine specimens were identified as being from patients with BRH. Histopathologic changes in renal biopsy specimens from most of the 9 patients consisted of either normal or slightly proliferative glomerulonephritis. Characteristic alterations were observed by electron microscopy, which showed the presence of small amounts of electron-dense deposits within the mesangium. In addition, immunofluorescent staining of peripheral blood lymphocytes from patients with BRH and their family members showed an increase of IgA-bearing peripheral blood lymphocytes, and the emergence of microhematuria among the families of patients with BRH indicates that some familial factors may be involved in the development of BRH and IgA nephropathy, which suggests that these two disorders may be closely related.

Adolescent↗
PubMed1979

Perimedial fibroplasia of the renal artery: a light and electron microscopic study.

Six cases of perimedial fibroplasia of the renal artery were studied by light and electron microscopy. The perimedial fibrous area was mainly composed of irregularly proliferated collagen fibers and scattered smooth muscle cells. We could not identify the usual fibroblast in any portion of the abnormal media despite examination with the electron microscope. There were many thin-walled, newly formed vessels sprouting from the adventitia in the fibrous area. We observed the complication of dissecting aneurysms in two cases. We also discussed the possible role of the smooth muscle cells in the fibrous area of perimedial fibroplasia.

Adult↗
PubMed1978

Polypoid carcinoma of the esophagus. A unifying term for "carcinosarcoma" and "pseudosarcoma".

Polypoid carcinomas with spindle-cell sarcomatous features have been designated either as carcinosarcoma or pseudosarcoma. The distinction between these two tumors has depended on the presence of "intermingling" of the carcinomatous and sarcomatous components in so-called carcinosarcoma. But unlike the carcinosarcoma, the sarcomatous component in pseudosarcoma has been considered benign. A polypoid tumor of the esophagus in a 57-year-old male was predominantly composed of spindle cell, sarcomatous cells. The presence of adjacent intraepithelial epidermoid carcinoma with transitional and ultrastructural features confirmed the epithelial origin of this tumor. Because of the absence of "intermingling," the primary tumor was considered to be a pseudosarcoma. However, our postmortem examination showed metastases composed of both carcinomatous and sarcomatous features. A review of the literature on carcinosarcomas and pseudosarcomas shows that only one case of pseudosarcoma reported by Hughes and Cruickshank showed a similar situation and indicates that the sarcomatous component in pseudosarcomas has the same metastatic potentiality as has been reported in carcinosarcomas. We conclude from these studies a basic similarity of the carcinosarcoma and pseudosarcoma. The term polypoid carcinoma is proposed for both these lesions.

Bronchial Fistula↗
PubMed1978

Plasma protein production by human tumors xenotransplanted in nude mice.

For detection of plasma proteins produced by human malignant tumors, a survey of blood plasma obtained from nude mice bearing serially transplanted human tumors was performed by immunoelectrophoresis and the double immunodiffusion technique. Among 34 lines including 18 types of human tumors, human specific plasma proteins were demonstrated in the plasma of nude mice transplanted with two lines of renal cell carcinoma, one adenocarcinoma of the colon, and one squamous cell carcinoma of the maxillary sinus. These tumors can be designated as "ectopic" plasma protein-producing tumors since the organs or tissues from which they originated are not considered to be usual sites of plasma protein synthesis. Plasma protein production, as well as that of alpha1-fetoprotein, was also found in one line of hepatoblasotma and three lines of yolk sac tumors. The above tumors were shown to produce one or more of the following 10 of 20 plasma proteins examined: albumin, prealbumin, alpha1-antitrypsin, ceruloplasmin, alpha2-macroglobulin, hemopexin, haptoglobin, C3 and C4 component of complement, and transferrin. An immunochemical demonstration of human specific cancer products observed in human tumors xenotransplanted into nude mice may provide a new approach for investigating the metabolism of neoplastic cells.

Adenocarcinoma↗
PubMed1976

Intraventricular free wall dissection causing acute interventricular communication with intact septum in myocardial infarction.

This report delineates a previously unrecognized complication of acute myocardial infarction, an intraventricular wall dissection producing interventricular communication without septal perforation. The clinical, hemodynamic, and pathologic features of this unique condition are documented, as well as the factors important in the mechanism of its production.

Aged↗
PubMed1976

Tubular stenosis of the aorta with aortic fibromuscular dysplasia.

The autopsy findings in a 2-year-old girl with severe hypertension resulting from stenosis of the lower part of the thoracic and the abdominal aorta were reviewed. The lower portion of the thoracic aorta and the abdominal aorta showed uniform narrowing down to the level of the bifurcation of iliac arteries. Histologically, the aortic wall of the stenotic site showed irregular proliferation of smooth muscle cells and collagen fibers. The elastic fibers had disappeared from outside the media. No intimal thickening and inflammatory cell infiltration were observed. These histologic changes of the aortic media in this case are apparently similar to fibromuscular dysplasia (medial hyperplasia).

Aorta, Abdominal↗