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Biomedical subjects

J Harvey

Publications and source records attributed to J Harvey.

At least 253 records · Page 14Linked to original sources
PubMed1982

Studies of testicular and epididymal damage in relation to the occurrence of antisperm antibodies.

The relationship between testicular histopathology, follicle stimulating hormone levels, sperm density and the presence of antisperm antibodies was investigated. There was no association between damage to the seminiferous tubules and the presence of agglutinating or immobilising antisperm antibodies. In 2 patients with congenital obstructive azoospermia and pre-biopsy circulating antisperm antibody there was extensive lymphocytic, macrophage and plasma cell infiltration, fibrosis and perivasculitis on epididymal biopsy. Breaches in the blood epididymis barrier are worthy of further investigation when considering the genesis of antisperm antibodies.

Autoantibodies↗
PubMed1982

The pharmacology of benoxaprofen with particular to effects on lipoxygenase product formation.

Benoxaprofen has three pharmacological activities which may relate to its clinical activity profile. The most important of these for anti-inflammatory therapy is the regulation of directional monocyte movement in response to a stimulus but the inhibitory activity against lipoxygenase may be of considerable relevance in the treatment of asthma. The relatively weak inhibitory action on prostaglandin synthetase probably confers clinical benefit with a reduced potential to cause severe gastric side effects. Benoxaprofen is an inhibitor pf the lipoxygenase enzyme which converts arachidonic acid to hydroxy derivatives and the leukotrienes. These products are potent pharmacological agents with potentially important roles in inflammation and hypersensitivity disorders.

Anaphylaxis↗
PubMed1982

Severe pneumonia.

The successful management of severe pneumonia involves a logical approach to antibiotic therapy, based on selecting drugs active against the most likely pathogen in each individual case while awaiting possible identification of an organism. In patients who deteriorate, more invasive diagnostic procedures should be considered in combination with broader-spectrum antibiotic treatment. Controlled oxygen therapy monitored by arterial blood-gas tension measurements is essential and mechanical ventilation may be indicated in some cases. Other measures including physiotherapy, fluid replacement, and the relief of pleuritic pain should not be forgotten.

Acute Disease↗
PubMed1981

Mistletoe hepatitis.

A 49-year-old woman presented with nausea, general malaise, and a dull ache in the right hypochondrium. Liver biopsy showed slight inflammatory-cell infiltration, and results of liver function tests suggested hepatitis. Hepatitis B surface antigen was not detected, and a cholecystogram was normal. Two years later she presented with similar symptoms, and both illnesses were found to have occurred after ingestion of a herbal remedy containing kelp, motherwort, skullcap, and mistletoe. A challenge test established this to be the cause of the illness. Mistletoe is the only constituent of the tablets known to contain any potential toxin and thus was probably the cause of the illness. Mistletoe is widely used in herbal remedies, whose ingestion may therefore cause hepatitis.

Chemical and Drug Induced Liver Injury↗
PubMed1981

Rheumatoid arthritis in a Chippewa Band. I. Pilot screening study of disease prevalence.

The Mille Lacs Band of Chippewa Indians in central Minnesota was screened for rheumatoid arthritis, with a 77% completion rate of the reservation census. Rheumatoid arthritis was found in marked excess, namely 6.8% of those evaluated or, minimally, 5.3% of the total band if all persons had been evaluated with no additional cases identified. This relatively closed population thus provides an opportunity to assess genetic and environmental factors of significance in this disease.

Adolescent↗
PubMed1981

HLA-DR characterization of a Chippewa Indian subpopulation with high prevalence of rheumatoid arthritis.

The adult population (N = 227) of a Chippewa Indian reservation in central Minnesota is characterized by a high prevalence of arthropathy with 7.1% having rheumatoid arthritis (RA). In a prospective study 168 reservation residents (74%) were evaluated. Complete HLA typing identified 57 haplotypes, many of which probably arose via HLA-A/B or B/D recombination. The number of founder haplotypes appeared to be about 20. The population frequency of DR4 (including DRw9, formerly designated 4 X 7) was 67%; for RA it was 100% (p less than 0.05). Apparent DR4 homozygotes, a number of the RA patients, and family members were selected for further study in a mixed lymphocyte culture (MLC) test and with 8th International Workshop cellular and serologic reagents. In MLC with homozygous typing cells (HTC), non of the DR4+ cells typed for any known HLA-D specificity, although they reacted to all DR4 antisera on the local panel. However, 8th International Workshop DR antisera revealed patterns of reactivity with non-DRf4 reagents consistent with the MLC. A minimum of three DR4 variants, one DRw9 variant, and a specificity related to both DR4 and DR2 are required to explain both the cellular and serologic reactions. For the present, we are designating the antigens as DR4.1chip, DR4.2chip, DR4.3chip, DR9chip, and DR(2 X 4)chip. No single variant of DR4 was characteristic of the RA patients in this Amer-indian population.

Adolescent↗
PubMed1981

Factors modifying vitreous pressure in cataract surgery.

A prospective study of 267 intracapsular cataract extractions was conducted to assesses what makes an eye soft and capable of safely receiving an intraocular lens implant. The study showed that the use of glycerol, given orally before the operation, plus retrobulbar anesthesia is the most effective way of reducing the vitreous pressure, that there is a direct relation between this reduction and age, and that there is no apparent correlation between the preoperative intraocular pressure and the vitreous pressure.

Adult↗
PubMed1979

PGE1 metabolism by the perfused rat liver.

The hepatic and biliary metabolites of PGE1 have been isolated and identified after infusions of PGE1 into isolated rat liver preparations. The results demonstrate that in general PGE1 undergoes metabolism similar to that of PGE2 in the rat and reveals the possibility of a selective PG metabolite transport system across the biliary canalicular membrane.

Animals↗
PubMed1977

The treatment of acute superficial abscesses: a prospective clinical trial.

A total of 219 acute superficial abscesses was treated. Patients were randomly allocated to one of four treatment groups--primary suture with or without antibiotics and free drainage with or without antibiotics. No difference could be detected between the groups in duration of healing time. Eleven per cent of all abscesses sutured recurred and antibiotics did not affect this rate. It is suggested that free drainage following incision and drainage is the safest treatment for the majority of abscesses. Antibiotics do not have any significant effect on healing time or recurrence and their routine use is not recommended.

Abscess↗
PubMed1977

Familial X-linked mental retardation with an X chromosome abnormality.

An X-linked pattern of transmission observed in four families with familial mental retardation in several generations was associated with a probable secondary constriction at the distal end of the q arms of the X chromosome. Twenty retarded males and no retarded females were observed. All available live retarded males and most of their normal mothers were found to have the abnormal X chromosome. The marker chromosome was shown to be the X chromosome in each case by Giemsa banding. In affected male and female carriers the marker chromosome varied in appearance and was not present in all metaphases. The significance of this study in relation to previously reported pedigrees showing non-specific X-linked mental retardation is discussed.

Adolescent↗