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Biomedical subjects

J Handa

Publications and source records attributed to J Handa.

At least 181 records · Page 10Linked to original sources

[Dissecting aneurysm of the anterior cerebral artery: report of a case].

A 43-year-old man suddenly experienced severe headaches and involuntary flexion-extension movements of four limbs, which were followed by hypertonic extension of the limbs lasting for a few hours. Two days later, he experienced generalized tonic seizure without loss of consciousness. After the seizures, he remained hemiparetic on the right side. His past medical history was non-remarkable, and the histories of hypertension, diabetes mellitus, head trauma and significant infectious diseases were all denied. Cerebral angiography performed 22 days after the onset showed a segmental, irregular narrowing of the left A2 segment and an aneurysmal outpouching immediately proximal to the stenosis. CT scan revealed a low density area in the left frontal lobe, corresponding to the territory of the involved left anterior cerebral artery. Cerebral angiography was repeated twice in the succeeding 6 months. Each time, the involved A2 segment showed persistence of narrowing, but its shape showed definite changes with the passage of time. A diagnosis of dissecting aneurysm of the anterior cerebral artery was reached by the characteristic angiographic features, and the patient was treated conservatively. Dissecting aneurysm of the cerebral arteries have been reported much less frequently than those of the aorta or other extracranial arteries. Recently, however, such reports are increasing in number, seemingly due to enhancement of knowledge of typical angiographic features, such as string sign, rosette sign, pearl reaction, double lumen and several others. Most of intracranial dissecting aneurysms involve the middle cerebral artery or vertebral-basilar artery, and the ones involving solely the anterior cerebral artery as in this present case are very rare.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

[Surgical treatment of atlanto-axial dislocation. An introduction of two new methods].

In the past fourty-two months we have operatively treated twenty cases of several types of atlanto-axial dislocation (AAD) including an atlanto-axial deformity. A transoral retropharyngeal approach to the anterior arch of the atlas and the body of the axis was performed in two cases of AAD with dens fracture, 2 traumatic pure anterior AAD with relatively narrow spinal canal and 1 os odontoideum. The operative method we have devised is a modification of the transoral micro-surgical odontoid resection. In hyperextended position the fractured dens or os odontoideum comes to the position nearest to the anterior arch of the atlas and a distance between the atlas and the axis almost disappears. In this position a Halo device is installed and the anterior arch of the atlas, the dens and the body of the axis are fixed by an autograft all together. The articular joints between the atlas and the axis are also fixed by small grafts. The "three points fixation" of the atlanto-axial vertebrae may be a better and safer operative technique for selected AADs. Another method for AAD is a posterior atlanto-axial fixation using a metal plate (Urlich Medical Instruments Co., West Germany). This technique is a modification of fixation with wire and methyl methacrylate. A strong point of this new method is that the laminae of the atlas, axis and C3 vertebra in some cases, are fixed not with wire but a plate. The wire is used only to fix the plate on the laminae, so that the wire is not snapped on elastic fatigue.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Subdural tension pneumocephalus after trephination for chronic subdural hematoma].

Symptomatic tension pneumocephalus developed after an evacuation of chronic subdural hematoma is reported. In this 71 year-old man, a rapid deterioration of consciousness was noted 5 days after a trephination for bilateral chronic subdural hematomas. An evacuation of hematoma was performed under a local anesthesia, and the preoperative and immediate postoperative course was uneventful. Subdural tension pneumocephalus was confirmed by typical CT findings and treated by re-trephination and drainage. The literature on the tension subdural pneumocephalus was reviewed, and the mechanism of its development was briefly discussed.

Aged↗

Ruptured cerebral aneurysms associated with arterial occlusion.

Seven cases of ruptured cerebral aneurysm associated with an occlusion of a large cerebral artery are reported. All seven patients had never suffered from ischemic cerebrovascular disease before the aneurysmal rupture. All nine aneurysms, including the two unruptured ones, arose on the artery serving as an important collateral pathway, and eight of the nine were found in locations where saccular aneurysms are known to occur infrequently. The role of hemodynamic factors in the pathogenesis of these aneurysms is stressed.

Aged↗

Dynamic computed tomography and functional imaging in cerebral vascular anomalies.

Dynamic computed tomography was performed on patients with cerebral vascular anomalies, the density-versus-time curves were derived, and the gray-scale functional images demonstrating the pixel-by-pixel distribution of several flow parameters were processed. This noninvasive method was found to be useful not only in delineating the vascular anomalies with their afferent and efferent vessels, but also in detecting the abnormal flow patterns within and outside the vascular anomalies. Limitations and distinct advantages of this technique are briefly discussed.

Adolescent↗

Suprasellar yolk-sac tumor in two sisters.

The familial occurrence of intracranial tumors is rare except in patients with phacomatoses. The occurrence of suprasellar yolk-sac tumors in two sisters without phacomatoses is reported. The pertinent literature is reviewed, and the possible role of heredity in the pathogenesis of these tumors is discussed briefly.

Brain Neoplasms↗

Toxicological studies on bestatin. III. Chronic toxicity test and recovery study in beagle dogs.

Chronic toxicity and its recovery of bestatin (NK421) was studied in both sexes of 28 Beagle dogs. At dose levels of 96, 38.4 and 15.4 mg/kg, NK421 was administered orally to dogs for 540 successive days. Control dogs were treated orally with 2 g/dog of corn starch. Each group consisted of 3 males and 3 females, and 2 males and 2 females were added to the 38.4 mg/kg group for a recovery test of 35 days. As general signs, anorexia, abnormal feces (loose stool, diarrhea, mucous stool), loss of activity, loss of lustre in fur, decoloration of the visible mucosa and emaciation were transiently observed in a early stage in 1 male and 1 female of the 96 mg/kg group. In correlation with these signs, slight anemia appeared hematologically, and the increased alkaline phosphatase activity and the decreased albumin ratio in serum protein fractions were observed biochemically. Except for the slight abnormal findings observed in the liver of the above 2 dogs, no significant changes were histopathologically noticed in any organ of all the dogs examined. The maximum non-toxic dose of NK421 in this study is estimated to be 38.4 mg/kg in dogs.

Animals↗

Superior sagittal sinus thrombosis followed by subdural hematoma.

A case of superior sagittal sinus thrombosis followed by a subdrual hematoma is reported. A 33-year-old woman, who presented with serious neurological deficits, made a remarkable recovery with mild residual. She had a thin subdural fluid collection, which eventually developed into a subdural hematoma. After evacuation of the hematoma, she had no neurological deficits. Treatment of cerebral venous and dural sinus thrombosis is discussed.

Adult↗

Conservative management of congenital defect of skull and scalp.

A case of congenital defect of the scalp and skull, treated conservatively with success, is reported. The defect of the scalp healed rapidly and the underlying osseous defect closed within eight months. The course of obliteration of the osseous defect was followed using radiological methods.

Bone Diseases↗