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Biomedical subjects

J Haller

Publications and source records attributed to J Haller.

At least 127 records · Page 7Linked to original sources
PubMed1989

Optimal needle size for renal biopsy: in vitro and in vivo evaluation.

To evaluate the success and complication rates of small (16- and 18- gauge) needles in biopsy of the kidney, the authors performed in vitro biopsy in a cadaveric kidney and in vivo renal biopsy in 141 patients. Best results were obtained with a 16-gauge modified Menghini needle. In vitro, 9.7 +/- 5.7 (mean +/- standard deviation) glomeruli were retrieved, and the average length of tissue cores was 17.8 mm +/- 8.2. In vivo, 10.63 +/- 6.64 intact glomeruli were retrieved, and a definitive histologic diagnosis was achieved in 86% of patients. The frequency of major complications with this needle was 3.5%, and of minor complications, 5.8%. No major complications occurred after biopsy was performed with 18-gauge needles of the same design. However, the retrieval rate of glomeruli with these smaller needles was insufficient. An 18-gauge needle with two cutting edges yielded tissue cores of 11.0 mm +/- 3.5 in length. In vitro, 6.6 +/- 2.3 glomeruli were retrieved; in vivo, 9.92 +/- 6.65. A definitive histologic diagnosis was achieved with this needle in 75% of patients, and rates of 7.1% for major complications and 10.7% for minor complications were encountered.

Adult↗
PubMed1989

Fatigue fracture of the sacrum: a case report.

We report a patient with a stress fracture in the sacrum. This may be a cause of hip or back pain. In contrast to typically bilateral insufficiency fractures, fatigue fractures are usually unilateral and the appearances are not diagnostic on scintigraphy. As the plain film findings may be subtle and overlooked, computed tomography is more specific in delineating a sclerotic vertical fracture parallel to the sacroiliac joint. Recognition of the characteristic radiographic pattern in sacral fatigue fractures can avoid incorrect diagnosis and unnecessary tests or treatment.

Adult↗
PubMed1988

Zipper encodes a putative integral membrane protein required for normal axon patterning during Drosophila neurogenesis.

During the development of the central nervous system, Drosophila embryo axons become organized in a stereo-typed fasciculation pattern. We have found that the zipper (zip) gene, initially identified on the basis of a defective larval cuticle in zip mutant embryos, is possibly involved in the establishment or maintenance of the axon pattern during the late stages of neurogenesis. The zip wild-type gene is expressed in the developing nervous system. It codes for a putative integral membrane protein. Both the molecular features of zipper and its biological effect in the nervous system of mutants suggest that zipper is an essential component for cell surface interactions involved in axon patterning, and that the cuticle phenotype of zip mutants is dependent on the primary defects observed in the nervous system.

Amino Acid Sequence↗
PubMed1988

Skeletal involvement in hairy cell leukemia.

The clinical and radiographic aspects of two patients with destructive bone lesions, complicating the course of hairy cell leukemia are presented. The findings are compared with those of 27 previously published cases. The most prominent features of this rare skeletal disorder are osteolysis and widespread or localized demineralisation with predilection for the femoral head and neck. Localized persisting pain is the leading clinical symptom in all cases. Magnetic resonance imaging is helpful in evaluating the extent of bone marrow infiltration and demonstrates focal areas of decreased signal intensity in sites of radiographically detectable bone destruction as well as in bones that appear normal on plain films.

Bone Neoplasms↗
PubMed1988

Biochemical energetics of hierarchy formation in Betta splendens.

Two different stages of hierarchy formation in Betta splendens were considered. Winners and losers in a short social contact, and dominant and submissive individuals after the establishment of a hierarchy, respectively, were identified. Metabolical determinations (free glucose, glycogen and protein content, glycogen and protein synthesis, glucose and amino acid oxidation, carbohydrate degradation) were performed. Winners and dominant individuals were shown to be able to produce more energy per unit time than losers and submissives, respectively. Differences in energy metabolism between individuals found in different stages of hierarchy formation also occurred: the carbohydrate degradation reached very high values after a short social contact. This is related to the noticed substitution of aggressive encounters with threat displays in the course of cohabitation.

Aggression↗
PubMed1988

[Diagnostic imaging of hemangiopericytomas].

Eight patients with histologically verified hemangiopericytomas were examined by conventional radiographic techniques (plain films, angiography including cavography) as well as by duplex sonography, CT and MRI. These imaging techniques detected solid tumors with cystic compartments. A typical computed tomographic finding was intensive contrast enhancement within the tumor. Duplex sonography revealed blood flow in the periphery of the tumor. In contrast to reports by other authors no tumor calcification was found by plain film radiography.

Abdominal Neoplasms↗
PubMed1988

Spontaneous osteonecrosis of the tarsal navicular in adults: imaging findings.

We encountered five otherwise healthy adults with alterations of the tarsal navicular bone compatible with spontaneous osteonecrosis. Four women had bilateral involvement and one man had unilateral involvement. The patients were 23-71 years old. The disorder was initially described by Mueller and Weiss and should not be confused with Koehler disease (osteochondrosis of the tarsal navicular in children). This group of patients was compared with five other patients (29-74 years old) with similar radiographic and clinical changes in whom an underlying disease (rheumatoid arthritis, renal failure, trauma, and lupus erythematosus) associated with osteonecrosis was known. Routine radiography in both groups defined characteristic abnormalities of the navicular bone (decreased size, a comma-shaped configuration, increased radiodensity, fragmentation, and medial or medial and dorsal osseous protrusion). MR in three patients confirmed alterations consistent with osteonecrosis. Three of the patients without underlying disease had bilateral involvement on plain films, with flat feet and hindfoot valgus deformity, leading to local pain and deformity. In a fourth patient, bilateral distribution was documented by MR as marrow alterations. Although no certain pathogenic explanation for spontaneous osteonecrosis of the tarsal navicular is known, trauma and chronic stress changes caused by physiologic pressure on the medial longitudinal arch in hindfoot valgus and increased tension forces of the plantar aponeurosis during weight-bearing (in pes planus) may be important. Discrimination of primary from secondary osteonecrosis of the tarsal navicular bone is not possible by radiologic means alone, although bilateral distribution, particularly in women, favors the diagnosis of spontaneous disease.

Adult↗
PubMed1988

[High-resolution sonography in cryptorchism].

The importance of high-resolution sonography in the localization of undescended testes was displayed by an evaluation of 18 patients. In 15 patients the testis was not palpable on one side. In 3 cases, there was retention of the testis on both sides. Out of 17 testes in the inguinal region or in the external iliac region, 16 were located sonographically. There were 4 intraabdominal testes, and 2 were located sonographically. The retained and impalpable testes were in superficial positions in most cases. Hence, sonography proved to be the primary imaging method for localization. The importance of computed tomography, magnetic resonance imaging and phlebography of the internal spermatic vein are also discussed.

Adolescent↗
PubMed1988

Septic arthritis.

Infectious arthritis is a commonly encountered clinical problem which may result from articular contamination by a wide variety of organisms. Involvement of an articulation may occur by one of four mechanisms: hematogenous spread, spread from a contiguous source of infection, direct implantation, or postoperative contamination. Distribution is typically monoarticular with a swollen, erythematous, and painful joint. The radiographic differential diagnosis includes limited rheumatoid arthritis, gout, synovial osteochondromatosis, and pigmented villonodular synovitis. In order to prevent complications, including growth disturbances, articular destruction with ankylosis, osteomyelitis, or soft tissue extension, early diagnostic arthrocentesis is important. Radiographic abnormalities, which include soft tissue swelling, joint space loss, periarticular osteopenia, and central or marginal osseous erosions, may be delayed following clinical onset of infection. Advanced imaging techniques such as scintigraphy, CT, or MRI may allow accurate diagnosis of the infectious process at an earlier stage.

Arthritis, Infectious↗
PubMed1988

Arthrography, tenography, and bursography of the ankle and foot.

A brief description of normal anatomy and common arthrographic, tenographic, and bursographic procedures is presented. The described procedures are important diagnostic tools and do not carry major risk. Therefore, these procedures can be performed on an outpatient basis.

Ankle↗
PubMed1987

Effect of dimethyl sulfoxide on island flap perfusion and survival in rats.

Investigations of the effect of dimethyl sulfoxide (DMSO) on skin flap survival have generated mixed results. In addition, to our knowledge, the effect of systemic DMSO on skin flap blood perfusion has not been previously studied. For this study, 48 rats were divided into three groups: (1) a control group, (2) a group injected with DMSO postoperatively only (for seven days), and (3) a preoperatively injected group (for three days preoperatively and seven days postoperatively). The DMSO was given intraperitoneally at a dose of 1.5 g/kg. On each rat, an abdominal island flap (3 X 6 cm) was raised and restored to its original site. Laser Doppler velocimetry and perfusion fluorometry were used to monitor flap perfusion immediately following surgery (day 0) and on postoperative day 3. Flap survival was significantly greater in the DMSO-treated groups when compared with the control group. Significant increases in blood perfusion were noted in the treated flaps on day 3.

Animals↗
PubMed1987

The gooseberry-zipper region of Drosophila: five genes encode different spatially restricted transcripts in the embryo.

Genetic analysis of the Drosophila chromosome region 60 E9-F1 identified two functions affecting embryonic development; gooseberry (gsb), a segment polarity gene, and zipper (zip), an unclassified gene which affects cuticle formation severely. By contrast, molecular analysis revealed five genes with different temporal and spatial patterns of expression in the embryo. Candidate genes for gsb and zip functions were identified. Two adjacent genes are eventually expressed in regular stripes within the posterior region of each segment. One of them is expressed initially in a pair-rule mode; the second gene expresses reduced levels of transcripts in a mutant which leaves the transcribed region and the sequences up to the second gene intact. This observation, the patterns of transcripts in the embryo and the genetic data suggest that both genes are involved in gooseberry segmentation function. zip is expressed in neural tissue and not in epidermal anlagen. Embryos lacking zip activity also develop abnormal neural tissue consistent with the argument that the zip cuticle phenotype is a secondary effect. Additional newly identified genes are expressed in specific domains of the embryo, covering mesoderm anlagen and the dorsal region of embryos at blastoderm stage, respectively.

Journal Article↗
PubMed1987

Accessory spleen: presentation as a large abdominal mass in an asymptomatic young woman.

Accessory spleen hypertrophy is usually related to hematologic, lymphomatous, and rheumatoid diseases. We describe here the case of an 18-year-old asymptomatic woman who presented with a very large accessory spleen occupying the lower abdomen. Its appearance on abdominal sonogram, computed tomogram, and hepatosplenic scintigraphy is correlated with the resected specimen.

Abdominal Neoplasms↗
PubMed1987

Duplex sonography of tumors of the carotid body.

Five histologically confirmed tumors of the carotid body and seven lymph node metastases in the area of the carotid bifurcation were investigated with real-time sonography. In addition, 10 patients underwent measurements of intratumorous flow by way of a pulsed Doppler system. The typically hypervascular tumors of the carotid body revealed flow signals with standardized adjustment of Doppler sonography. The hypovascularized lymph node metastases did not demonstrate flow on Doppler sonography. In all patients, either preoperative angiography or enhanced computerized tomography was done and these studies confirmed the degree of vascularization of the mass as determined by Doppler sonography. Duplex sonography permitted noninvasive demonstration of hypervascular tumors in the area of the carotid bifurcation, a finding highly suggestive of nonchromaphil paraganglioma of the carotid body.

Adult↗
PubMed1987

Dorsal and neural expression of a tyrosine kinase-related Drosophila gene during embryonic development.

Sequence analysis of an embryonic transcript of Drosophila predicts a tyrosine protein kinase-related gene. The prediction is based on several protein domains that are homologous to the functional domains of kinase-related oncogenes and several serine, threonine, and tyrosine protein kinases. For this reason, we named this gene Drosophila tyrosine kinase related (dTKR). dTKR maps into chromosome band 2R 60F1. It is initially expressed at blastoderm stage, showing transient transcript accumulations at dorso-lateral positions of the embryo and differences along its longitudinal axis. At later stages of embryogenesis, dTKR transcripts are found exclusively in neural anlagen. Both the region-specific pattern of expression and the putative kinase function are consistent with the suggestion of a regulatory role for this gene during development, which remains to be elucidated.

Amino Acid Sequence↗
PubMed1987

[Occult and clinically suspected testicular tumor. Assessment using real-time sonography].

The diagnostic value of real-time-sonography was evaluated in 62 patients with suspected and occult testicular tumors. In 28 patients intratesticular tumors were identified on real-time-sonograms. In addition 7 clinically occult tumors were diagnosed by real-time-sonography. It was not possible to differentiate between orchitis and tumors on sonograms (3 cases). There was correlation only between the morphologic appearance of tumors on sonograms and the corresponding histology. Using high frequency transducers sonography proved to be an useful diagnostic modality to identify or to rule out occult intratesticular tumors.

Diagnosis, Differential↗