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Biomedical subjects

J H Vos

Publications and source records attributed to J H Vos.

64 records · Page 4Linked to original sources
PubMed1986

Lobular capillary haemangiomas in young horses.

Seven cases of cutaneous haemangiomas in young horses are described, characterized by scattered, well demarcated but unencapsulated lobules, consisting of capillary sized vascular structures, separated by strands of fibrous tissue. In one case, a more cellular variant was distinguished with minor vasoformative capacity. The morphological features of these haemangiomas are compatible with bovine cutaneous angiomatosis and human granuloma pyogenicum. The lesions are considered to be vascular tumours rather than hamartomas or granulation tissue and "lobular capillary haemangioma" is suggested to designate this type of haemangioma. In one tumour, cavernous vascular structures were also present in addition to the capillary structures and so this tumour is considered to be a combined capillary and cavernous haemangioma.

Animals↗
PubMed1985

Spinal nematodosis in a donkey with posterior paresis.

Spinal nematodosis in a four-year-old donkey is described. The animal showed progressive hindlimb paresis of sudden onset. Necropsy revealed extensive degeneration and inflammation in the lumbosacral part of the spinal cord, caused by a nematode larva of the suborder Strongylina, probably L4 or L5 of Strongylus vulgaris.

Animals↗
PubMed1985

Necrosis and rupture of the aorta and pulmonary trunk in four horses.

Four horses are described with rupture of the aortic arch and pulmonary trunk which resulted in a fistula between these vessels. Ruptures were located near the ligamentum arteriosum. Histological examination of the vessel walls revealed media necrosis which was probably due to intimal thickening and/or medial fibrosis of the vasa vasorum.

Animals↗
PubMed1985

Amyloid in canine mammary tumors.

In canine mammary carcinomas, amyloid was present as amyloid-containing corpora amylacea and as local deposits between neoplastic epithelial cells or in stromal tissue. Histochemical staining methods revealed that this amyloid was not of the AA-type amyloid and contained tryptophan. The possible pathogenesis of this amyloid deposition is discussed.

Adenocarcinoma↗
PubMed1984

Double outlet left ventricle in a dog.

A four-month-old toy poodle bitch with growth retardation, coughing, decreased exercise tolerance and cyanotic mucous membranes had a systolic murmur and cardiomegaly. There was severe concentric hypertrophy of the right ventricle and both the aorta and pulmonic trunk originated from the left ventricle.

Animals↗
PubMed1983

Neurological disorders, virus persistence and hypomyelination in calves due to intra-uterine infections with bovine virus diarrhoea virus. I. Clinical symptoms and morphological lesions.

The clinical and pathological findings after a natural intra-uterine infection with BVD-virus in a Friesian dairy herd are described. The virological and serological aspects will be discussed in a separate paper (30). In a period of 4 years, 11 calves were born with the following nervous symptoms: more or less serious incoordination, tremor, oscillating nystagmus, and a negative blinking reflex. The pupillary and sucking reflexes were normal. No ocular defects, such as lenticular opacity or retinal atrophy were observed. The first calf was born in 1979. Within 6 months the symptoms disappeared. After a normal conception and pregnancy this animal gave birth to 2 clinically normal calves in 1981 and 1982. The second calf died at the age of 2 months, due to an ulcerating enteritis. In 1980, again 8 calves with the same nervous symptoms were born within a period of 3 months. Two calves died at the age of 3 days and 5 weeks respectively; 2 calves were sold when 10 days and 3 weeks old; one calf did not improve and was necropsied at the age of 17 days. The remaining 3 calves showed only a slight hypermetria when examined after 6 months. At that time nystagmus was only visible with ophthalmoscopy. Two calves were slaughtered when 10 months old. The last one, a bull, proved to be sterile and was necropsied at the age of 1 1/2 year. A calf, born in 1981, recovered within a week and was necropsied at the age of 15 days. The last calf, born in 1982, did not improve at all and was necropsied at the age of 14 days. During these 4 years none of the other animals in the herd showed any symptoms due to an acute or chronic BVD-virus infection. At post mortem examination of 6 animals no macroscopically visible malformations were found. Hypomyelination and abnormal glial cells were evident in 5 cases, especially in the two youngest calves which did not show any improvement. One of them had had an obvious thymic hypoplasia. The calf which recovered within a week showed only very slight changes. In one of the calves slaughtered at 10 months, inflammatory lesions were found in the brain. The diagnosis was confirmed by virological investigations. Clinically as well as pathologically there was a close resemblance to Border disease in lambs and congenital tremor in piglets after prenatal exposure to Hog cholera virus.

Animals↗
PubMedDate not supplied

Flow-cytometric DNA ploidy analysis in primary and metastatic canine thyroid carcinomas.

DNA ploidy was measured by flow cytometry in 36 primary malignant thyroid neoplasms (including 6 bilateral tumours which were considered as separate neoplasms) from 30 dogs. In addition, DNA ploidy was determined in local recurrences in 3 dogs, and in 18 metastatic sites from 14 dogs. Aneuploidy was found in 21 of 36 (58%) primary sites. Eighteen of the 21 (86%) aneuploid tumours contained hypodiploid cell populations, with 12 having single hypodiploid peaks, and 6 being multiploid. Three other tumours had single aneuploid peaks with a DNA index (DI) greater than 1.0. The DIs in local recurrences were identical to those in the original neoplasms. Ploidy status (diploid vs. aneuploid) was identical in primary and metastatic sites in 10 out of the 14 dogs. Aneuploidy was more frequent in carcinomas from dogs with distant metastases (78%) than from dogs with less advanced stages of disease (53%), although this difference was not significant. There was no significant correlation between DNA ploidy and histopathological variables. From the strikingly high frequency of hypodiploidy in canine tumours, it is concluded that ploidy evolution in canine neoplasms may differ from that in human tumours.

Aneuploidy↗
PubMedDate not supplied

The canine p53 gene is subject to somatic mutations in thypoid carcinoma.

In many different types of tumors in man and mouse, p53 is the tumor suppressor gene most frequently affected by a combination of somatic mutation and loss of the wildtype allele. In order to develop a molecular tool to study the genetic evolution of tumors in the dog, we have cloned an evolutionary conserved part of the canine homologue of p53. The isolated genomic segment, 534 bp in length, contains the 3' half of exon 5, the complete exon 6 and the 5' half of exon 7, as well as the intronic intervening sequences. The gene organization of this segment shows strong homology to that published earlier for a number of other species, including man, mouse, and Xenopus laevis. This conservation is apparent at the DNA sequence level, as well as at the deduced aminoacid sequence level. mRNA expression can be detected at low levels in normal tissues with increased mitotic activity, and in the Madin-Darby canine kidney cell line. A-->G T transversion was found in 1 out of 23 investigated primary thyroid carcinomas at a position corresponding to codon 174 in the human p53, and was predicted to give rise to an aminoacid substitution in the protein. These results suggest that p53 plays a role in the development of malignancy in the dog, in a way comparable to that in man.

Amino Acid Sequence↗