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Biomedical subjects

J H Vos

Publications and source records attributed to J H Vos.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Tumor cells and extracellular matrix with special reference to mamma tumors in dogs and cats].

The essence of the cell-matrix interaction in tissues is that cells influence the composition of the extracellular matrix but that, on the other hand, components of the matrix are also involved in the regulation of growth and differentiation of the cells. Interaction is also found to occur in tumours though in a different way, so that infiltration and metastasis and the occurrence of scirrhous carcinomas are the result. Canine and feline mammary tumours are interesting objects for the study of this interaction since fibroadenomatous changes, in which connective tissue is the predominating tissue, is a common finding in cats only, whereas mixed and complex mammary tumours, producing matrix components of varying type, are common tumours in dogs.

Animals↗
PubMed1990

The use of keratin antisera in the characterization of a feline thymoma.

A cystic mass in the anterior mediastinum of a 9-year-old female European Shorthair cat was classified as a lymphocytic thymoma based on its histopathological features which were in accordance with those reported in the literature concerning feline thymomas. The application of a polyclonal keratin antiserum and monoclonal keratin antisera RCK 102, RKSE 60 and RGE 53 resulted in staining of foetal feline thymic cells, oesophageal epithelial cells as well as numerous stellate tumour cells and Hassall's corpuscles. As a result, the epithelial origin of the neoplastic cells could be established and the classification of thymoma confirmed. The results indicate the value of keratin antisera in the differentiation of thymoma and non-epithelial tumours in the anterior mediastinum.

Animals↗
PubMed1989

[Myasthenia gravis and a thymoma in a cat].

A classical combination of myasthenia gravis and a thymoma is reported for the first time in a cat. The clinical symptoms, pathophysiological and histopathological characteristics are discussed.

Animals↗
PubMed1989

Canine capillary and combined capillary-cavernous haemangioma.

Six cases of capillary haemangiomas in the skin and one case in the tongue of dogs are described. There was no breed or age predisposition (average age was 8.9 years), but there was a prevalence of male dogs. In three cases, cavernous haemangioma-like structures were also found, so these tumours are considered to be combined capillary and cavernous haemangiomas.

Animals↗
PubMed1989

Non-exfoliative canine cytology: the value of fine needle aspiration and scraping cytology.

The results of the cytological and histological examination of 348 canine lesions, localised in various organs, were compared with respect to the tumourous or non-tumour nature of the lesions and the malignancy or benignancy of tumours. The retrieval rate was 92.5%. Regarding the distinction between tumourous and non-tumourous lesions, the cytological examination showed a diagnostic accuracy of 83.9%, a sensitivity of 95.6%, a specificity of 65.4% and a predictive value for the presence of tumour of 93.5%. The diagnostic accuracy of cytology concerning the differentiation in malignancy and benignancy of the neoplasms was 83.7%, with a sensitivity of 86.8%, a specificity of 79.4% and a predictive value for the presence of malignant tumour of 85.6%. These results confirm the value of non-exfoliative cytology as a diagnostic method, providing rapid and valuable information with regard to diagnosis and prognosis and, consequently, for therapeutic handling. An eventual histological diagnosis remains indicated, especially in case of soft-tissue and mammary lesions.

Animals↗
PubMed1989

Keratin staining of canine epithelial tissues by a polyclonal antiserum.

The keratin distribution pattern in various canine epithelial tissues has been studied using a commercially available rabbit antiserum, raised against human skin keratins, in an immunoperoxidase staining method with the peroxidase-antiperoxidase complex (PAP). The staining results of two fixation methods were compared. Paraffin sections after fixation in Carnoy's solution showed optimal results, whereas paraffin sections after fixation in 10% buffered formalin resulted in a strongly reduced keratin staining reaction. Keratinizing and non-keratinizing stratified epithelial showed a strong staining reaction. Glandular epithelium and the non-stratified epithelia of internal organs e.g. liver, kidney and intestine did not react with the antiserum. However, glandular ductal epithelium, myoepithelial cells and basal cells in various epithelial tissues showed a positive staining reaction. The results indicate the presence of different keratin types in these canine epithelial tissues. The keratin distribution pattern is compared with the distribution pattern observed in tissues of other species.

Animals↗
PubMed1989

An immunohistochemical study of canine tissues with vimentin, desmin, glial fibrillary acidic protein, and neurofilament antisera.

In a wide range of canine tissues the immunoreactivity with commercially available antisera against intermediate filament antigens viz. vimentin, desmin, glial fibrillary acidic protein (GFAP) and neurofilament proteins, was studied. In addition, the results of formalin and Carnoy fixation were compared. Carnoy fixation appeared to result in optimal reactivity for all antisera. Epithelial cells did not react with any of the antisera, with exception of ovarian surface epithelium, which showed staining with the vimentin and desmin antisera. The vimentin antiserum induced staining of several cell types viz. fibroblasts, endothelial cells, chondrocytes, Schwann cells, ependymal cells, astrocytes, Leydig cells, synovial cells, podocytes and some parietal cells of Bowman's capsule. Sertoli cells showed a faint staining reaction. Muscle cells in various tissues reacted with the desmin antiserum. In the kidney a varying number of parietal cells appeared to react as did a restricted number of epithelial cells of proximal tubules and loops of Henle. GFAP reactivity was confined to glial cells, predominantly fibrous astrocytes, Schwann cells and axons. Additionally, some neuronal cell bodies in peripheral ganglia showed staining of varying intensity. Neurofilament staining was restricted to axons and some neurons. The immunoreactivity of canine tissues with these antisera is compared to findings in other species. The results confirm a broad interspecies cross-reactivity of these antisera. They can be used in studying the nature of canine tissues.

Animals↗
PubMed1989

Canine perineal tumours.

One hundred and thirty nine canine perineal tumours were histologically evaluated. The vast majority (134 tumours = 96.4%) appeared to originate from the characteristic glandular structures of this region. They were classified as well differentiated perianal gland tumours (58.3%), as moderately or poorly differentiated perianal gland tumours (21.6%) and as carcinomas without perianal gland differentiation (16.5%). Only 5 tumours (3.6%) appeared to originate from non-characteristic perineal structures. A prominent male predominance was found with respect to the perianal gland tumours, whereas the carcinomas showed a distinct female predisposition. Tumours showing perianal gland differentiation almost invariably will have a benign behaviour. The carcinomas lacking any perianal gland differentiation often show a distinct malignant behaviour with metastases to regional lymph nodes and internal organs. These malignant neoplasms showed morphological and clinical features comparable to canine anal sac gland adenocarcinomas and carcinoids in man and animals.

Adenocarcinoma↗
PubMed1988

[Pieris japonica pieris poisoning in 2 goats].

Two fatal cases of Japanese pieris poisoning in goats are reported. The clinical symptoms of the two animals consisted in vomiting, salivation, excitation and depression. Despite rumenotomy and symptomatic treatment, the goats died within four days after the onset of the symptoms. Pulmonary oedema accompanied by lobular aspiration pneumonia was found to be present in one goat at autopsy. Hyperaemia, pulmonary oedema and acute tubular nephrosis were observed in the other animal.

Animals↗
PubMed1987

[Oropharyngeal tumors in dogs and cats: a review].

The literature on canine and feline oropharyngeal tumours is reviewed. Particularly in dogs, these neoplasms are not uncommon. Papillomas, and particularly epulides, are the most common benign tumours in dogs. Four types of epulides are differentiated viz. fibromatous, ossifying, acanthomatous and giant cell epulis. Acanthomatous epulides frequently infiltrate into bone locally and are potentially capable of transforming themselves into squamous cell carcinomas. Malignant melanoma, squamous cell carcinoma and fibrosarcoma are the most important malignant neoplasms which usually show a highly malignant biological character. Benign oropharyngeal tumours are uncommon in cats. Squamous cell carcinoma is the most common feline neoplasm. Canine and feline odontogenic and bone tumours are briefly discussed, other uncommon oropharyngeal tumours being merely referred to.

Animals↗
PubMed1986

[Mycotic placentitis in cattle].

Two cases of bovine mycotic placentitis are reported. The two cows did not show any clinical symptoms before or during premature delivery of two clinically normal calves. In both placentas a severe placentitis accompanied by extensive necrosis and a large number of hyphae was present in two placentas. Aspergillus fumigatus was isolated in one case. The literature on bovine mycotic placentitis is reviewed in the discussion.

Animals↗
PubMed1986

Dystrophy-like myopathy in the cat.

Two cases of feline myopathy are described which were associated with moderate locomotor disturbances. At necropsy, a pale coloured skeletal musculature was found with severe hypertrophy of diaphragmatic musculature. Histologically, the myopathy was characterized by varying fibre diameter, internal nuclei, moderate degeneration and necrosis of solitary muscle fibres and slight to moderate endomysial and perimysial fibrosis. Only very few regenerating muscle fibres were present. The histological findings are compatible with those found in human muscular dystrophies and so this feline myopathy may be considered as a dystrophy-like myopathy.

Animals↗