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Biomedical subjects

J H Drew

Publications and source records attributed to J H Drew.

At least 73 records · Page 4Linked to original sources
PubMed1976

The effect of maternally administered drugs on bilirubin concentrations in the newborn infant.

The effects of drugs administered to pregnant women on bilirubin concentrations in 1,107 consecutively born infants are presented. Administration of narcotic agents, barbiturates, aspirin, chloral hydrate, reserpine, and phenytoin sodium all resulted in lowering of infant serum bilirubin concentrations. Diazepam and, to a lesser extent, oxytocin caused an elevation of infant serum bilirubin concentrations. Although many drugs were shown to alter serum bilirubin levels significantly, the clinical importance of such alterations was not dramatic except possibly in special circumstances. The phenothiazine derivatives, general or local anesthesia, sulfadimidine, ampicillin, and penicillin had no such effect on the newborn infant when given to the mother before delivery.

Bilirubin↗
PubMed1976

Jaundice in infants of Greek parentage: the unknown factor may be environmental.

Studies of infants born in Melbourne, Australia, to parents who migrated from Greece failed to demonstrate an increased incidence or severity of neonatal jaundice. No effect of birthplace of parents within Greece on serum bilirubin levels could be discerned. These findings indicate that the high frequency of severe neonatal jaundice which has been demonstrated throughout Greece, and especially in certain regions of that country, is not carried with those who immigrate. Further studies of this problem in Greece should concentrate on regional environment rather than upon genetic influences.

Australia↗
PubMed1976

Phototherapy. Short and long-term complications.

Use of phototherapy for hyperbilirubinaemia in 300 consecutively treated infants has shown that minor complications are common. With a knowledge of these complications and measures taken to minimize their effects, phototherapy appears to be safe in the short term. The long-term follow-up study showed that growth, and in particular head circumference, was not affected. There was, however, a higher incidence of squints and abnormal developmental performance in those infants treated with phototherapy. This may not have been due to phototherapy usage per se. However, because of these findings, it is suggested that phototherapy should not be used indiscriminately for hyperbilirubinaemia until the results of further long-term studies are available.

Bilirubin↗
PubMed1976

Radiological findings in newborn infants with urinary infection.

Selective suprapubic urine aspiration was performed in 905 of 12 942 consecutive live-born infants and showed the presence of infection in 64 (0-5%). A majority (84%) of the infected infants were males. Radiological abnormalities were detected in 35 (55%). Because of this high incidence of abnormalities, which when diagnosed might alter management, it is suggested that radiological investigations be performed in newborn infants with proven urinary infection.

Female↗
PubMed1975

The effect of fetal and placental weight at birth on weight during early childhood.

A study of children whose birth weights or placental weights were above the 90th or below the 10th percentile for gestational age indicated that bigness at birth tends to be an innate quality, as the majority of those who were large at birth remained oversized. The small at birth are not all destined to remain diminutive, as the children in this category attained a normal distribution curve for weight during the first year of life. Thus smallness at birth may represent intrauterine nutritional deprivation and be overcome with normal access to calories. The influence of the placenta on infant size is temporary and is modified by extrauterine nutrition. Thus, although there was a direct relationship between birth weight and placental weight, the distribution of weight of children with either large or small placentas was not significantly different from the expected normal distribution at one year of age.

Birth Weight↗
PubMed1975

Children born from pregnancies complicated by subnormal oestriol excretion--first year.

This paper is the first of a series concerning the follow-up of children whose mothers had subnormal oestriol excretion during pregnancy. The incidences of still births, neonatal deaths, dysmaturity and major and minor congenital malformations were significantly increased in pregnancies complicated by one or more subnormal oestriol value. Growth parameters and developmental progress were measured of 136 infants who attained the age of one year, and it was encouraging to find that no gross departures from normal were observed.

Birth Weight↗