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Biomedical subjects

J Gruber

Publications and source records attributed to J Gruber.

At least 55 records · Page 3Linked to original sources
PubMed1994

Apoptosis and therapy of malignant diseases of the hematopoietic system.

Apoptosis is essential in the pathogenesis of hematological diseases. A tumor develops, if the balance between cell division and cell death is disturbed. In recent years many genes involved either in blocking or inducing this process have been identified. Additionally, several cytokines which influence apoptosis have been found. Some of these cytokines could also play a role in the development of resistance to chemotherapeutic agents. Many anticancer drugs exert their action via apoptosis. A strategy to selectively induce apoptosis of tumor cells without altering healthy cells and thus reducing the side effects of therapeutic regimens is a major goal for future development of new therapeutic techniques. Blocking the factors which are responsible for resistance is another promising therapeutic approach and could further improve the clinical outcome and finally prolong the life of patients.

Animals↗
PubMed1994

The incidence of mandated maternity benefits.

I consider the labor-market effects of mandates which raise the costs of employing a demographically identifiable group. The efficiency of these policies will be largely dependent on the extent to which their costs are shifted to group-specific wages. I study several state and federal mandates which stipulated that childbirth be covered comprehensively in health insurance plans, raising the relative cost of insuring women of childbearing age. I find substantial shifting of the costs of these mandates to the wages of the targeted group. Correspondingly, I find little effect on total labor input for that group.

Adult↗
PubMed1992

Neurohistological findings after experimental anterior cruciate ligament allograft transplantation.

A multiplicity of surgical operations have been developed in an attempt to achieve satisfactory function after anterior cruciate ligament (ACL) repair. None of these procedures have been able to duplicate the fiber organization, anatomy of the attachment site, vascularity, or function of the ACL. Eighteen foxhounds received a deep-frozen bone-ACL-bone allograft and a ligament augmentation device. Neurohistological changes were evaluated 3, 6 and 12 months following implantation. The modified silver impregnation method and gold chloride technique were used to examine the presence of nerve endings and axons. Two morphologically distinct mechanoreceptors were identified and classified as free nerve endings and Golgi-like tendon receptors respectively. Fine nerve endings frequently ramified freely into ligament collagen bundles. Nerves and blood vessels were commonly associated. As in normal ACLs, both neuroreceptor types were mostly located near the surface of the allografts and at the two bony attachments. This study demonstrated the first histological evidence of viable mechanoreceptors and free nerve endings in transplanted ACL allografts, not previously reported in other ACL substitutes used for ACL reconstruction. Particularly importantly for postoperative rehabilitation, this technique may allow the reconstruction of the proprioceptive functions of normal ACLs.

Animals↗
PubMed1992

Anterior cruciate ligament allograft transplantation for intraarticular ligamentous reconstruction.

A multiplicity of surgical operations have been developed in an attempt to achieve satisfactory function after anterior cruciate ligament (ACL) repair. None of these procedures have been able to reproduce the fiber organization anatomy of attachment site, vascularity, or function of the ACL. Twenty-nine foxhounds received a deep-frozen bone-ACL-bone allograft and a ligament augmentation device (LAD). Biomechanical, microvascular, and histological changes were evaluated 3, 6, and 12 months following implantation. The maximum loads of the allograft/LADs were 34.3% (387.2 N) after 3 months, 49.3% (556.6 N) after 6 months, and 61.1% (698.8 N) after a year. The maximum load was 69.1% (780 N). In general, after 6 months the allografts showed normal collagen orientation. The allografts demonstrated no evidence of infection or immune reaction. No bone ingrowth into the LAD was observed. Polarized light microscopy and periodic acid-schiff staining showed that the new bone-ligament substance interface had intact fiber orientation at the area of the ligament insertion. Microvascular examination using the Spalteholtz technique revealed revascularization and the importance of an infrapatellar fat pad for the nourishment of ACL allografts.

Angiography↗
PubMed1992

Effects of sex steroid analogs on spontaneous autoimmune thyroiditis in obese strain chickens.

Treatment of obese strain chickens, either in ovo or after hatching, with testosterone or various testosterone-derived steroid analogs having no or only weak endocrine activities causes significant protection from spontaneous autoimmune thyroiditis occurring in these birds. This effect is not correlated with the endocrinological properties of these steroids. This observation and similar results in other models for autoimmunity may present a basis for a more selective therapy in human autoimmune diseases in that hormonal side effects no longer preclude this approach.

Age Factors↗
PubMed1992

[Eczema herpeticum in children: clinical picture and therapy].

The authors submit information on the course and therapeutic experience with acyclovir (Zovirax Wellcome Co. and Herpesin Lachema Co.) in 67 children with eczema herpeticatum (EH) who were hospitalized at the Clinic of Infectious Child Diseases in Brno from January 1983 to January 1991. In all instances treatment led to rapid drying of the herpetis eruptions, a shorter period of new eruption and rapid improvement of the serious clinical condition. In none of the children visceral dissemination of the virus of herpes simplex (HSV) were occurred and in none of the children toxic side-effects were found. The authors confirmed the assumed identical course of EH after i. v. administration of acyclovir of foreign or local origin. After i.v. administration frequently dramatic improvement of the general and local finding was recorded, as compared with oral administration. There were no therapeutic differences in the clinical effects of tablets and suspension, the clinical effect being comparable.

Child↗
PubMed1990

A 3-month evaluation of the efficacy of nedocromil sodium in asthma: a randomized, double-blind, placebo-controlled trial of nedocromil sodium conducted by a Canadian multicenter study group.

Nedocromil sodium is a pyranoquinoline dicarboxylic acid derivative, formulated in a metered-dose inhaler. Because nedocromil sodium has in vitro and in vivo anti-inflammatory properties, it was evaluated in a group of steroid-dependent patients with asthma to observe how well it might be tolerated and for evidence of any beneficial effects. In a double-blind, group-comparative study, 127 patients received nedocromil sodium and 61 received placebo, administered as two puffs of 2 mg, four times per day, for 12 weeks. Ten patients developed adverse reactions, seven receiving active drug and three patients receiving placebo. Two patients of each group withdrew because of worsening asthma. Despite selecting patients whose asthma was stable, when they were receiving established therapeutic regimens that included steroids and bronchodilators, it was found that diary-card symptom scores, morning and evening peak expiratory flow rate values, and inhaled beta-agonist usage all demonstrated slight but significant benefit with addition of nedocromil sodium. It is concluded that the inhaled, anti-inflammatory agent, nedocromil sodium, may be added to asthma-treatment regimens with the reasonable expectation of further modest symptomatic benefit.

Adult↗