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Biomedical subjects

J Gough

Publications and source records attributed to J Gough.

At least 91 records · Page 5Linked to original sources
PubMed1972

Pulmonary disability in coal workers' pneumoconiosis.

Results from a correlation survey which compared radiological and physiological findings during life with detailed morbid anatomical findings in the lungs of 247 deceased miners and ex-miners with pneumoconiosis were used to assess the extent and significance of their pulmonary disability.Coal workers' pneumoconiosis usually caused progressive impairment of ventilation, which in the simple type of disease was not related to radiological category. In such cases the presence of emphysema was found to be a more important factor in determining the impairment of ventilation than the radiological category of simple pneumoconiosis.

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PubMed1970

Emphysema in coal workers' pneumoconiosis.

A correlation survey has been carried out between the pathological, physiological, and radiological findings pertaining to emphysema in 247 deceased coal miners and ex-miners, most of whom had been diagnosed as suffering from coal workers' pneumoconiosis during life. The pathological findings, which included large lung sections and detailed histology in every case, were compared with similar findings in a contrast non-mining population matched for age and sex.The results indicated that emphysema was much more common among the coal miners, both with simple and with complicated pneumoconiosis, than among the contrast group. In addition the extent of the emphysema as measured by a recognized "counting" method carried out on paper-mounted lung sections was remarkably closely related to ventilatory impairment as evidenced by the forced expiratory volume in one second.Extensive emphysema was more commonly found in those pneumoconiosis cases, both simple and complicated, showing the finer punctiform type of radiological change than in cases showing the larger micronodular and nodular opacities.

Adult↗
PubMed1970

Identification of mineral particles in pneumoconiotic lungs.

An extraction replication technique has been used for the study, by electron microscopy, of lung tissue from a number of different cases of pneumoconiosis. The technique provides a relatively simple means of studying the surface area of replicated tissues, and any foreign particles present which are either replicated or extracted from the tissue can be identified. A set of standard micrographs of different types of mineral particles likely to be encountered should be kept for reference. Most of the particles identified by this technique were beyond the limits of resolution of optical microscopy. Furthermore, the procedure involves the minimum of chemical and physical treatment. The histochemical diagnosis and industrial history was confirmed in the first two cases described, by the electron microscopy investigations. The third case presented an uncertain histological and industrial history, but an electron microscopy study confirmed the presence of the mineral particle considered responsible for the clinical condition. The fourth and fifth cases described illustrate the use of this technique in identifying a particular type of pleomorphic mineral, and illustrating its position in situ in relation to surrounding tissue.

Adult↗
PubMed1967

Significance of a "starry sky" in lymphosarcomata in Britain.

Four cases of lymphosarcomata are described in which the histological pattern was identical to that seen in Burkitt's lymphoma. The anatomical distribution was dissimilar in that the disease predominantly affected the reticulo-endothelial system. The arrangement of the histiocytes and lymphoid cells in these tumour groups is similar to that of macrophages and lymphocytes in rosettes seen in leucocyte cultures under certain conditions, and it is suggested that an immunological factor may be responsible for these appearances.

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