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Biomedical subjects

J Gottlieb

Publications and source records attributed to J Gottlieb.

At least 91 records · Page 5Linked to original sources

Special-class EMR children mainstreamed: a study of an aptitude (learning potential) X treatment interaction.

Academic, personal, and social growth were compared for special-class EMR children who were assigned randomly to regular grades or retained in special classes at three time intervals: prior to the assignment, 2 month after assignment, and at the conclusion of the school year. There were no significant differences between the two groups prior to or 2 months after reintegration. After one school year, the reintegrated children were more internally controlled, had more positive attitudes toward school, and were more reflective in their behavior. The hypothesis that the more able students by the learning potential criterion would benefit more from regular than special-class placement was supported. These students expressed more positive feelings toward themselves as students, felt others perceived them as more competent, and behaved more reflectively when they were integrated than when assigned to special class. The high-able (learning potential) students performed more competently academically than the low-able (learning potential) students, regardless of placement.

Achievement↗

A phase II study of methyl CCNU in the treatment of solid tumors and lymphomas: a Southwest Oncology Group study.

In March of 1972, the Southwest Oncology Group initiated a Phase II study, No. 7200, utilizing methyl-CCNU in the treatment of patients with solid tumors and lymphomas. Initially, they received 200 mg/m2 orally as a single dose every 6 weeks. The dose was subsequently reduced in poor-risk patients to 150 mg/m2. There were 69 responses noted in 675 evaluable patients (10%). The highest response rates were noted in patients with Hodgkin's disease (13/31, 35%), malignant gliomas of the brain (8/29, 28%), anaplastic carcinomas of the lung (5/20, 25%), and squamous cell carcinomas of the head and neck (5/29, 17%). Squamous cell tumors appeared to be more responsive than adenocarcinomas (15% vs. 5%, respectively). Hematologic toxicity was cumulative, and was influenced by dose and prior treatment. There appeared to be no cross-resistance in patients previously treated with alkylating agents. Methyl-CCNU is an active antineoplastic agent. Further studies are indicated in order to determine relative effectiveness.

Adenocarcinoma↗

Public attitudes toward mentally retarded children.

The recent trend toward integrating mentally retarded children in the community and public school warrants examination of public attitudes toward these children. Factor analysis of equestionnaire responses of 430 adults revealed for factors underlying attitudes toward retarded children: positive stereotype, segregation in the community, segregation in the classroom, and perceived physical and intellectual handicap. Older respondents, parents of school-aged children, and people with no previous contact with a retarded person tended to favor segregation of retarded children in the community. Results of this study suggest that attitudes of these groups must be addressed if retarded persons are to be successfully integrated into society.

Adult↗