Miconazole in fungal endophthalmitis.
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Candidiasis↗
Biomedical subjects
J Gallo
Publications and source records attributed to J Gallo.
The treatment of severe Raynaud's phenomenon with verapamil.
Verapamil was evaluated in 16 patients with severe Raynaud's phenomenon. Fifty per cent of patients experienced subjective improvement by history, but only one patient had a substantial reduction in the frequency of Raynaud's phenomenon as assessed by diary analysis. We conclude that verapamil is not effective in most patients with severe Raynaud's phenomenon.
Clinical Trials as Topic↗
Serotypes of red clover necrotic mosaic virus. II. Typing of 34 isolates.
Examination of 34 isolates of red clover necrotic mosaic virus (RCNMV) from Czechoslovakia in agar gel double diffusion precipitation tests and immunoelectrophoresis in agarose gel showed that 16 isolates belonged to serotype B, 6 isolates to serotype C and 4 isolates to serotype A; 3, 1 and 4 isolates represented mixtures of serotypes A + B, A + C and B + C, respectively. The distribution of the individual RCNMV serotypes in Czechoslovakia is not bound to definite geographic areas; two serotypes were even involved in mixed infections of single plants. Isolates of a given serotype were serologically and electrophoretically identical with the respective type isolate, i.e. there was a correlation between antigenic properties and electrophoretic mobility.
Immunodiffusion↗
Serotypes of red clover necrotic mosaic virus. I. Characterization of three serotypes.
Three serotypes (A, B and C) were distinguished based on serological differences between isolates of red clover necrotic mosaic virus (RCNMV). Isolate TpM34, representative of serotype A, induced the formation of antibody only against homologous antigen. By contrast, isolate TpM48, representative of serotype B, induced the formation of 3 groups of antibody; the group of type-specific antibody was present in a higher titre than the other two antibody groups. Isolate 63/70, representing serotype C, also induced the production of type-specific antibody in a higher titre as compared with antibodies reacting with type A and B antigens. The distinct behaviour of the 3 serotypes was also manifested on immunoelectrophoresis in agarose gel. In anionic barbital buffer, serotypes A and C showed a higher mobility than representatives of serotype B, but in cationic environment serotype A showed a higher mobility than serotypes B and C.
Antigens, Viral↗
[Cerebral emergencies and solar activity (author's transl)].
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Cerebrovascular Disorders↗
Subcutaneous parotid effusion after mandibular osteotomy.
A case of subcutaneous parotid secretion after extraoral vertical mandibular osteotomy for prognathism has been described. The possible causes have been discussed and a rationale for conservative management has been suggested.
Humans↗
Corneal rings with gram-negative bacteria.
Corneal rings have been described with corneal ulcerations caused by Gram-negative bacteria. Corneal rings were produced by intracorneal injections of viable Pseudomonas aeruginosa as well as heat-inactivated suspensions of Gram-negative bacteria (P aeruginosa and Escherichia coli) but not Gram-positive bacteria (Staphylococcus aureus) or Freund's adjuvant. It is suggested that endotoxin is the factor responsible for their production since purified endotoxin produced corneal rings after intracorneal injection. Histopathological examination of the areas corresponding to the corneal rings disclosed that the rings represented accumulations of polymorphonuclear leukocytes. Direct immunofluorescent studies of the corneal rings revealed staining for properdin and C3 complement but not for immunoglobulins. The present report suggests that endotoxin has the ability to stimulate the alternate pathway of complement through properdin activation with the production of chemotactic fragments that attract polymorphonuclear leukocytes into the cornea.
Animals↗
Transmission of alfalfa mosaic virus through Nicandra physaloides seeds and its localization in embryo cotyledons.
Alfalfa mosaic virus (AMV) was found to be transmitted through seeds of Nicandra physaloids L. The average seed transmission rate of the AMV isolates T6, LMBG-4 and ST amounted to 23, 4 and 0 per cent, repectively. In the cytoplasm of parenchyma cells of embryo cotyledons of seeds from plants infected with the T6 isolate, electron microscopy revealed AMV aggregates of type 2A and aggregations of irregularly viral particles with a tendency to subparallel alignment, representing early stages of type 2A aggregates.
Cytoplasm↗
[A primary epithelioid hemangioendothelioma localized in the pulmonary valve].
A case of epithelioid haemangioendothelioma sited at pulmonary valve, with an excrescence growing invading pulmonary artery troncus and its principal branches, in a 56-year-old woman is reported. The evolutive behavior simulated some clinical situations which made difficult the diagnosis: a mild-moderate pulmonary stenosis, a general syndrome, and, finally, an acute pulmonary thromboembolism that carried to an aggressive management which conducted to the entity diagnosis.
Emergencies↗
Findings in 50 AIDS virus-infected patients with positive oral Candida cultures.
Oral candidiasis is a common complication of HIV-infected-individuals. The purpose of this study was to evaluate clinical and laboratory findings to assess the impact and efficacy of antifungal treatment. This preliminary report describes findings in 50 HIV-positive, candida culture-positive subjects (49 males, 1 female; mean age: 39 years). The group had been known HIV-positive for a mean of 28 months, and 19 met the CDC/WHO definition for AIDS (63%, KS, 21% PCP). Thirty-four of the fifty patients had oral signs of candidiasis, with almost half having both atrophic (red) and pseudomembranous (white) components. In quantitating the cultures, the higher colony forming unit counts in general were correlated with clinical signs and pain. The other most common oral manifestations were periodontal disease, hairy leukoplakia and xerostomia. The most common candida species was albicans (84%). Response to initial antifungal therapy was satisfactory clinically, but erratic regarding CFU quantitation, species changes, and bacterial emergence. In summary, oral candidiasis is a complex infection with uncertainties as to the significance of quantitation and achieving control.
Acquired Immunodeficiency Syndrome↗
Three recent cases of the total artificial heart before transplantation.
Three recent cases from one institution using the total artificial heart (TAH) before transplantation are reviewed. The first patient was implanted for 12 hours with the pneumatic Phoenix total artificial heart after failure of a donor heart 1 day after transplant. Following retransplantation the patient died from severe pulmonary edema, pulmonary hypertension, right ventricular failure, and Pseudomonas septicemia. The second patient was implanted with the Jarvik-7 total artificial heart for rapidly deteriorating idiopathic cardiomyopathy. Major complications during the 9 1/2-day implant consisted of severe pulmonary edema for the first 4 days and a multifocal cerebral embolic event on the seventh day after implantation from which he fully recovered. Major problems after transplant included disseminated toxoplasmosis and two mild episodes of rejection. The patient was discharged 68 days after surgery and remains well. The third patient was a 40-year-old woman with rapidly progressing acute influenza A viral myocarditis. Despite immunosuppressive and antiviral therapy, cardiogenic shock with multiple organ failure developed. The 70 ml Jarvik-7 was implanted for 4 1/2 days. Acute humoral rejection from autoantibodies and alloantibodies led to a cardiac arrest on the second day after transplantation. A second 70 ml Jarvik-7 implant was followed by severe multisystem and infectious complications. After prolonged intensive care support, the patient recovered and is now awaiting transplantation. Nearly 100% cytotoxic antibody reactivity caused by multiple antigenic stimuli is preventing ready access to donor hearts for this patient. We view the current role of the total artificial heart as a tool to preserve life until a suitable donor heart can be found, reverse the end-organ effects of progressive heart failure and low output, and restore transplant candidacy in selected patients with temporary reversible contraindications to transplantation.
Adult↗