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J Friedman

Publications and source records attributed to J Friedman.

301 records · Page 17Linked to original sources
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Gene-centromere mapping in Xenopus laevis.

Gynogenesis was used to map eight loci to their centromeres in Xenopus laevis. Several loci remote from their centromeres were identified. This information may be useful in distinguishing gynogenetic diploid progeny produced by suppression of second polar bodies from gynogenetic diploid progeny homozygous at all loci produced by suppression of first cleavage of gynogenetic haploids.

Animals↗
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[Distal occlusions].

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Audiometry↗
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Long-acting diltiazem CD is safe and effective in a hypertensive Mexican-American population.

STUDY OBJECTIVE: To evaluate the safety and effectiveness of diltiazem CD for reducing blood pressure in Mexican-American patients with mild to moderate hypertension. DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Twelve clinical sites in the United States. PATIENTS: Patients with baseline diastolic blood pressures between 95 and 115 mm Hg. INTERVENTIONS: Patients were treated with an average daily dose of diltiazem CD 246 mg (60 patients) or placebo (58 patients) to achieve a trough diastolic blood pressure below 90 mm Hg. MEASUREMENTS AND MAIN RESULTS: Diltiazem CD significantly reduced mean diastolic blood pressure compared with placebo, -8.2 versus -4.1 mm Hg, respectively (p=0.0025). Diastolic blood pressure below 90 mm Hg or a reduction of 10 mm Hg or more was achieved by 57% of diltiazem CD versus 28% of placebo recipients. Systolic blood pressure and heart rate were also reduced with diltiazem CD. Adverse events were mild, with similar frequency for diltiazem CD (15%) and placebo (19%). CONCLUSION: Diltiazem CD is safe and effective in hypertensive Mexican-Americans, and diastolic blood pressure reductions compare with those in non-Hispanic white patients.

Adolescent↗