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Biomedical subjects

J Frick

Publications and source records attributed to J Frick.

At least 127 records · Page 7Linked to original sources
PubMed1982

BCG-induced orchitis: structural changes during the degeneration of seminiferous tubules of rats and rabbits.

The effect of BCG-induced orchitis on the structure of the seminiferous tubules in rats and rabbits was investigated by light and electron microscopy. The formation of cavities between Sertoli cells and the displacement of the cells of the spermatogenic cycle are the earliest changes to be observed. Individual Sertoli cells and the displacement of the cells of the spermatogenic cycle are the earliest changes to be observed. Individual Sertoli cells degenerate and separate from spermatocytes and spermatids. The latter form multinuclear complexes by a broadening of the intercellular bridges. The nuclei of spermatids undergo ring-like chromatin condensation in the rat and swelling in the rabbit. After the loss of spermatocytes and spermatids from the germinal epithelium, the remaining Sertoli cells have a very irregular shape and contain many residual bodies, which are probably derived from previously phagocytosed spermatids. They often contain crystalline inclusions. The nuclei of Sertoli cells show small chromatin condensations. In the rabbit, the tubular wall increases considerably in diameter. In the vicinity of a granuloma in the interstitium caused by BCG inflammatory cells accumulate around the wall of the seminiferous tubules. Although the basal lamina seems to be an obstacle, penetration of macrophages into the tubular lumen could be observed. However, this occurred only after the degeneration of the germinal epithelium.

Animals↗
PubMed1982

Spermatogenesis in men treated with injections of medroxyprogesterone acetate combined with testosterone enanthate.

The effects of a combination of medroxyprogesterone acetate and testosterone enanthate, on the exocrine and endocrine testicular function were examined in adult men. The treatment was carried out with 2 different regimens and lasted for 8 months. Group I received an initial injection of 1000 mg medroxyprogesterone acetate and 500 mg testosterone enanthate followed by monthly maintenance dose of 150 mg medroxyprogesterone acetate and 500 mg testosterone enanthate. In group II, after an initial high dose of 1000 mg medroxyprogesterone acetate and 250 mg testosterone enanthate treatment was given as biweekly injections of 75 mg medroxyprogesterone acetate and 250 mg testosterone enanthate. Complete spermatogenic arrest of variable duration was achieved in all 9 subjects enrolled. Restoration of spermatogenesis occurred in both groups, in a few cases during the treatment, and there was a delay of full recovery of sperm counts up to 5 months after cessation of therapy. None of the subjects enrolled in this study complained of decrease in libido or change in sexual behaviour. Clinical evaluation and measurements of various urine and serum components revealed no significant changes during the treatment period. The dosage and the different administration schedule of the hormone combination described here was inadequate to maintain azoospermia in all subjects during treatment.

Adult↗
PubMed1982

Testicular function after torsion.

A group of 20 patients with torsion was investigated. The study indicated that immediate surgical intervention with a period of torsion of the testis of less than 6 h will prevent impairment of testicle function. The histology of testicular biopsies taken from such patients revealed only interstitial oedema and, at the most, partial necrosis. If torsion time exceeded 6 h testicular histology revealed severe alterations, and surgical correction could not prevent atrophy of the testis. Patients with pathological spermiograms showed FSH values over or at the upper limit of the normal range. As far as can be concluded from one single basal hormone determination, the testosterone secretion remained unaltered. Libido, potency and virilization remained normal.

Adolescent↗
PubMed1981

[Bromocriptine induced cystic tumour regression in advanced prolactinomas (author's transl)].

Conservative treatment with bromocriptine was performed in three patients with macroprolactinomas and increased prolactin levels. Lowering of prolactin levels to normal or subnormal values was possible in all cases. One extensive prolactinoma with retro- and suprasellar parts showed regression to a large extent and cystic degeneration. Transient occurrence of liquorrhoea is considered as a consequence of tumour regression. In cases of parasellar prolactinoma recurrence and intrasellar prolactinoma diminution and cystic degeneration were observed while on bromocriptine treatment. Bromocriptine dosage varied between 3.75 and 30 mg/d. Treatment was performed between 20 and 26 months. There were no serious side effects. Bromocriptine treatment offers an alternative to surgery in macroprolactinomas and prolactinoma recurrences.

Adult↗
PubMed1981

Sonography in blunt renal trauma.

In 27 patients with blunt renal trauma, sonography was used as diagnostic method. In principle, sonography was performed after the urogram. In 15 cases pathological findings were present: 5 subcapsular and perirenal hematomas; 3 ruptured kidneys and 1 renal pedicle injury; in 6 cases pre-existing lesions of the kidneys were present (1 cyst, 3 hydronephrotic kidneys and 2 tumors). A positive urogram and a pathological sonogram lead to the angiography in particular when the possibility of injury of other organs is suspected, or when urographically a nonfunctioning kidney simulates a lesion of the renal pedicle. The adoption of this diagnostic sequence is most economical, it provides the clearest findings and is the least irksome for the patients.

Adolescent↗
PubMed1981

Subdermal implants of different steroidal compounds for treatment of endocrinological disorders.

Various types of steroid-containing implants were used in the treatment of benign prostatic hypertrophy, congestive prostatitis, and hypogonadism. 2 Silastic capsules, each containing 22-23 mg of ethinyl estradiol, were inserted subcutaneously in 5 men with benign prostatic hypertrophy. A decline in testosterone levels to less than 1 ng/ml was attained within 6 months following insertion. 6-8 Silastic capsules containing 21-23 mg each of testosterone were implanted in 15 men: 2 castrates and 13 hypogonadals. Testosterone levels increased initially, reaching the highest level at 3 months. Thereafter, the testosterone concentrations declined but remained slightly above pretreatment levels at 9 months. In a group of 9 subjects, 7 men with hypogonadism and 2 women with hypernephroma were treated with 2 rods, each containing approximately 200 mg testosterone propionate. Testosterone concentrations showed initial rises but did not remain elevated. 12 male subjects, 6 with congestive prostatis and 6 with benign prostatic hypertrophy, were treated with a combination of 3 levonorgestrel rods and 3 estrone rods. Each rod contained 40 mg of steroid. This regimen had a therapeutic effect but was only partially successful in inhibiting spermatogenesis.

Adult↗
PubMed1981

[Surgical management of vesico-renal reflux in adults].

27 units of ureterorenal reflux in adults were operated and analyzed between 1976 and 1980. It was shown that adequate preservation of function in refluxive kidneys with scarring grades I and II can be achieved by means of ureteroneocystostomy after the method of Cohen. The early removal of unilateral refluxive kidneys with high grade scarring is imperative. In cases of bilateral occurrence the indication for operative treatment should depend on the function demonstrated by isotopic investigations.

Adolescent↗
PubMed1980

Androgen substitution with testosterone containing nasal drops.

Testosterone proprionate in form of eye drops will not be absorbed. A good absorption takes place following the administration of testosterone containing nasal drops in the form of an emulsion of pure testosterone. A quick, significant testosterone increase but of only short duration takes place. Unpleasant side effects were not observed. This treatment may be clinically applicable to male patients in the climacteric period.

Administration, Intranasal↗
PubMed1980

The effect of chronic administration of a synthetic LH-RH analogue intranasally in cryptorchid boys.

Eighteen boys with either unilateral or bilateral cryptorchidism were treated with a synthetic LH-RH analogue ("D-Leu 6, Des-Gly-10 LH-RH ethylamide") intranasally. The peptide was dissolved in aqueous solution (25 micrograms in 0,2 ml) and administered in the form of nasal drops. The patients were divided in two groups: in group A, 50 micrograms of the synthetic LH-RH analogue were administered intranasally every 48 h for 36 days; in group B same dose was given every 24 h. Additionally, in 4 cases a LH-RH test prior the trial was performed with the same peptide. The nasal administration resulted in a fivefold increase of LH and of FSH plasma concentration in 30 min and in 60 min, respectively. The endocrine profiles for T, LH and FSH were studied in each group over the treatment period and in group B (same dose was given every 24 h) a significant decrease of the LH and FSH plasma levels could be found. The clinical effect of treatment was same in the both groups. In the whole material 44% had either unilateral or bilateral descent of the testis after the therapy.

Administration, Intranasal↗
PubMed1980

[Experiences with neoimplantation of the ureters following Cohen's method (author's transl)].

In the years 1977 to 1979 three operative procedures were used by us to correct vesico-ureteric reflux. The results in relation to 82 re-implanted ureters are presented. The indications for anti-reflux surgery are discussed in relation to the Cohen and Grégoir techniques. The Politano-Leadbetter technique was replaced by the Cohen method. The latter is simpler to perform and has a lower complication rate.

Humans↗
PubMed1979

Collagenase--a marker enzyme in human bladder cancer?

Collagenase activity in human bladder carcinomas was measured against 14C-labeled collagen as substrate. Enzymes activity in vivo increased with the degree of penetration of the bladder wall. It was not detectable or low in the cases of superficially infiltrating tumours (A, B1 B2) and high in the cases of deeply infiltrating tumours (C, D). These results suggest that collagenase activity of advanced tumours is predominantly expressed in the pervesical layer of the bladder wall. A quantitative estimate of this enzyme may thus help to distinguish between Stage C and Stage C tumour.

Adenocarcinoma↗
PubMed1979

Pregnancies associated with sperm concentrations below 10 million/ml in clinical studies of a potential male contraceptive method, monthly depot medroxyprogesterone acetate and testosterone esters.

A potential male contraceptive approach was evaluated in clinical trials involving monthly injections of depot medroxyprogesterone acetate and either subdermal implants of testosterone propionate or monthly injections of testosterone enanthate. Pregnancies occurred in partners of 9 men with recent sperm counts of 10 million/ml or below. In 5 of the 9 instances, the sperm counts were less than 1 million/ml. It appears that male contraceptive methods involving spermatogenic suppression may require attainment and maintenance of azoospermia. The pregnancy rate cannot be calculated, because the extent of other contraceptive use is uncertain. There were no spontaneous abortions. 6 pregnancies were carried to term, and all progeny were normal, based on physical examination at birth or 3 months after birth.

Contraceptive Agents, Male↗
PubMed1979

Electron microscopic stereological analysis of the normal human prostate and of benign prostatic hyperplasia.

Normal and benign hyperplastic prostatic tissue was studied by quantitative electron microscopic measurements. Quantitative morphological procedures provide values for volume, surface, number of tissue and cellular components within human prostatic tissue. When a comparison is made of the stereological data of the glandular cell of benign prostatic hyperplasia to that of the normal human prostate no statistically significant difference in the relative volumetric amount of the cell organelles is indicated. An attempt was made to characterize the fine structure of the smooth muscle cells of the stromal area (fibromuscular) in normal and benign hyperplastic prostatic tissue. In benign prostatic hyperplasia a significant increase in the relative amount of organelles in the smooth muscle cell was found, indicating an activation of these cells. Light microscopic analysis has revealed that benign prostatic hyperplasia is primarily a stromal disease.

Cytological Techniques↗
PubMed1979

Ultrasonic diagnosis of the retroperitoneal space.

A precondition for ultrasonic diagnosis of the retroperitoneum is an optimal preparation of the patient to eliminate flatulence in the intestines. If the large vessels of the retroperitoneum are well demarcated, the optimal examination conditions are present. Tumorous and cystic changes of 2 cm or more, can be visualized. Difficulties, however, in the coordination and the differentiation of retroperitoneal tumors from organic tumors (pancreatic tail, splenic and gynecological tumors) can arise. Tumor changes in the lymphatic nodes, the adrenal gland and the sympathetic trunk, tumors in the retroperitoneum from other causes, and aortic aneurysms are discussed.

Adrenal Gland Neoplasms↗
PubMed1979

Renal arterial thrombosis after the contralateral removal of a pelvic kidney.

In a 19-year-old female a pelvic kidney, on the left side, was removed because of recurrent urinary tract infections, severe abdominal complaints and a pathological isotope-nephrography. Following nephrectomy a severe uremia with cerebral edema and pneumonia developed based on a medial necrosis of the artery of the right kidney. After surgical correction the function of the right solitary kidney returned to normal.

Adult↗