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Biomedical subjects

J Fraser

Publications and source records attributed to J Fraser.

At least 109 records · Page 6Linked to original sources
PubMed1989

Occupational risks for brain cancer: a New Zealand Cancer Registry-based study.

Occupational risks for brain cancer were evaluated in a New Zealand Cancer Registry-based case-control study. The case subjects were 452 men aged 20 years or older registered under classifications 191 (Cancer of the brain) and 192 (Cancer of other and unspecified parts of the nervous system) of the International Classification of Disease (9th ed) from 1980 to 1984 for whom occupational information was available. The remaining 19,452 men with other cancers registered during an excess of professional and technical workers. An increased risk among workers in agriculture, forestry, and fishing was due to an excess of brain cancer in farmers, with the highest risk found for livestock farmers. Although many comparisons have been made, some of the findings support previous studies and several new hypotheses are suggested.

Adult↗
PubMed1989

Cancer risks among New Zealand meat workers.

The study reports a series of case-referent studies based on the New Zealand Cancer Register and involving 19,904 male cancer patients aged 20 years or more at the time of registration during the period 1980-1984. For each cancer site, the registrations for the remaining sites formed the reference group. An increased risk for lung (OR 1.30, 95% CI 1.06-1.58) and laryngeal (OR 2.01, 95% CI 1.19-3.39) cancer was found among meatworkers. It was confined to men aged less than 65 years at registration. The risk for soft-tissue sarcoma was elevated (OR 1.90, 95% CI 0.90-4.02). The risk estimate for all types of leukemia was elevated moderately (OR 1.45, 95% CI 0.90-2.31), but cell type-specific analyses revealed a greater effect for acute myeloid leukemia (OR 2.12, 95% CI 1.09-4.12). This study adds to the evidence that employment as a meatworker is associated with increased risk for several forms of cancer.

Abattoirs↗
PubMed1988

A national study of sudden infant death syndrome in New Zealand.

Although the sudden infant death syndrome is a major component of New Zealand's high postneonatal mortality rate, little is known about its national epidemiological patterns. In this paper, based on all cases born during 1981-83, the rate of sudden infant death syndrome was 4.2/1000 livebirths. The rate declined with maternal age, birthweight, and length of gestation, but increased with parity and Registrar-General's social class. Exnuptial and male births were also at high risk, as were births to Maori and New Zealand born mothers. There was a significant seasonal pattern and a distinct north-south gradient. The rate of sudden infant death syndrome in the south of the South Island was almost twice that in the north of the North Island. These patterns are, however, similar to those of the other preventable causes of postneonatal mortality. Future research into New Zealand's postneonatal mortality needs to consider all the possible preventable causes of mortality during this period of an infant's life, rather than concentrating on only one group of at-risk infants.

Adult↗
PubMed1988

Development of periodontal disease in a single flock of sheep: clinical signs, morphology of subgingival plaque and influence of antimicrobial agents.

The clinical development of broken mouth over a single reproductive year and the effect of two broad spectrum antibacterial agents upon it was followed in 72 Scottish Blackface ewes aged between two and three years. Using a number of dental health indices especially developed for the purpose, the amount of gingivitis, tooth movement, gum recession and pocketing were quantified and graphed for both the whole population and each group in the drug trial. All clinical features except movement fluctuated significantly with time, the fluctuations often being associated with nutritional or other environmental factors. Despite the extended use of large doses of two antimicrobial agents no significant reduction in the amount of clinical gingivitis or pocketing was evident.

Animals↗
PubMed1987

Time trends and occupational differences in cancer of the testis in New Zealand.

The findings are reported from a New Zealand Cancer Registry-based case-control study involving 427 male patients with testicular cancer registered during the period 1979-1983 and aged 20 years or more at time of registration. Controls were also males chosen from the Cancer Registry with two controls per case, matched on age and year of registration. It was found that, as in other countries, persons in the upper social class groupings were at increased risk of testicular cancer. Persons in professional occupations were also at increased risk, but the odds ratio of 1.09 was much smaller than found in other studies. The previously reported excess risks for farmers, food and beverage workers, forestry workers, and pulp and paper workers were not supported by the New Zealand data. On the other hand, the previously reported excess risk for sales and service workers including members of the armed forces was supported, to some extent, by the New Zealand data with odds ratios of 1.38 (95% confidence limits 0.98-1.93) and 2.15 (95% confidence limits 0.80-5.79), respectively. Other groups with elevated risk include: physicians (odds ratio = 6.50, 95% confidence limits 1.29-32.6); production supervisors (odds ratio = 2.85,95% confidence limits 1.00-8.13); and motor vehicle mechanics (odds ratio = 2.02, 95% confidence limits 0.93-4.42). However, the New Zealand data generally does not suggest that occupational factors (or lifestyle factors associated with occupation) are of major direct importance in the etiology of testicular cancer. The incidence of testicular cancer has a bimodal age distribution in New Zealand and has risen markedly during the period 1948-1979. The New Zealand data differed from patterns observed in other countries in that the relative increase was approximately uniform across age groups rather than being stronger in the younger age groups.

Age Factors↗
PubMed1987

Feasibility study of a statewide pathology-based cancer surveillance system in Minnesota. I. Information characteristics.

The Minnesota Department of Health has completed a 2-year feasibility study comparing the completeness and accuracy of information from pathology-based cancer ascertainment with that of the traditional surveillance method based on hospital discharge records. Overall, for incident cancers, the primary site designation of the pathology-based system was correct for 94.5% of the cancers, and the histologic designation was correct for 97.0% of the cancers. For prevalent cancers the accuracy of both site and histology designation was inadequate at 81.0 and 76.8% respectively. Pathology-based ascertainment was more complete than discharge-based surveillance (98.4% vs. 96.6%), which reflected the growing number of cancers diagnosed in hospital outpatient departments and medical clinics. The major limitation of the pathology-based system was the inability to determine from written pathology reports whether the cancer was newly diagnosed. However, when asked, pathologists correctly determined the incidence status for approximately 75% of the cancers. In light of the results of the feasibility study, Minnesota is implementing a pathology-based system as a cost-effective, scientifically valid method to meet the state's current and future needs for cancer surveillance.

Data Collection↗
PubMed1987

Case-control study of occupation and cancer of the prostate in New Zealand.

A New Zealand Cancer Registry based case-control study involved 617 male patients with prostate cancer registered during 1979 and aged 20 years or more at the time of registration. Controls were also males chosen from the Cancer Registry with two controls per case, matched on age and year of registration. There was an elevated risk in the upper social class groupings. The data did not support the findings, from other countries, of elevated risks in agricultural workers (odds ratio = 1.08, 90% confidence limits 0.86-1.36). The only occupational groups showing elevated risks were sales and service workers (odds ratio = 1.29, 90% confidence limits 0.99-1.69) and teachers (odds ratio = 2.44, 90% confidence limits 1.05-5.70). The New Zealand data do not in general suggest that occupational factors--or lifestyle factors associated with occupation--are of major direct importance in the aetiology of prostate cancer.

Humans↗
PubMed1986

Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

beta 2-Microglobulin (beta 2m) has been thought essential for transport of all major histocompatibility complex class I antigens to the cell surface. Here, we show that the mouse class I antigen H-2Db is expressed at the cell surface even when there is no beta 2m present within the cell. This was established by transfecting the H-2Db gene into the R1E cell line, which lacks beta 2m. The conformation of the Db antigen expressed by the R1E transfectant is very different from that of the native molecule. This Db antigen is not recognized by Db-allospecific and Db-restricted cytotoxic T lymphocytes or by most monoclonal antibodies to the native Db. We show further that a deletion construct of the Db gene, which consists of exon 1 linked to exons 4-8, expresses a truncated Db antigen lacking domains 1 and 2 [Db-(1 + 2)] at the cell surface after transfection into the R1E line. Previous biochemical and crystallographic data have indicated that domain 3 is associated with beta 2m; unexpectedly, Db-(1 + 2) does not associate with beta 2m when the mouse beta 2mb gene is transfected into the R1E transfectant expressing the truncated Db. This suggests that interactions with domains 1 and 2 are important for the paired association of domain 3 and beta 2m in the native Db antigen.

Animals↗
PubMed1986

Leukemia among New Zealand agricultural workers. A cancer registry-based study.

Mortality studies have indicated that workers in agriculture and forestry may be at increased risk of leukemia. Findings are reported from a New Zealand Cancer Registry-based case-control study involving 546 male leukemia patients registered during 1979-1983 and aged 20 years or more at time of registration. Controls were also males chosen from the Cancer Registry with four controls per case, matched on age and year of registration. The case group contained an excess of the occupational category involving agriculture and forestry (odds ratio (OR) = 1.24, 95% confidence interval (CI) = 0.95-1.61) with the greatest relative risk being for livestock farmers (OR = 3.00, 95% CI = 1.23-7.32). There was also an excess of electrical workers (OR = 1.72, 95% CI = 0.92-3.20). The agricultural excess was greatest in patients aged 65 years or more at time of registration (OR = 1.29, 95% CI = 0.94-1.78), particularly in patients with acute myeloid leukemia (OR = 1.55, 95% CI = 0.90-2.67) or acute monocytic leukemia OR = 10.38, 95% CI = 1.99-54.29), although the latter excess only involved five cases. Acute myeloid leukemia was also elevated in meat workers (OR = 2.51, 95% CI = 1.19-5.30).

Adult↗
PubMed1985

Migration and death from malignant melanoma.

The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants from the British Isles, early age at migration was associated with a mortality rate similar to that of New Zealand-born non-Maoris. In a community survey, British immigrants were not less likely to have had severe sunburn, but had fewer moles, than New Zealand-born non-Maoris. The lower melanoma mortality, and the effect of age at migration, could be mediated by differences in mole frequency.

Adolescent↗