Two groups of seven pregnant sows were farrowing either naturally after 111-114 days of gestation or prematurely after 109 days following an injection of 125 micrograms/animal of a prostaglandin analogue. Colostrum intake was controlled individually on piglets during the first 24 h of life. Measurements of IgG, IgA and IgM were performed on 3 samples of colostrum after 0, 12 and 24 h following the birth of the first piglet, then in the serum of the piglets, sampled at 4, 12 and 42 days of age. Then, we calculated the total amount of Ig intake during the first 24 h of life and an estimation of the Ig stores of each piglet on the basis of weight, blood volume, and hematocrit at different ages. Results showed a marked average difference in the birth weight in favour of mature piglets as well as an increased colostrum intake: 315 vs an average of 213 g for premature piglets. Considerable variations between sows were found in the initial level of colostral IgG, independently of the gestation length. Two thirds of the IgG intake by piglets occurred during the first 12 h. Total Immunoglobulin intake in the first day was respectively 15.8 g vs 25.1 g for premature or mature piglets. Total estimated Ig content in the serum of 4 day-old piglets was also lower for premature ones (2.55 vs 3.2 g/animal), representing 10 to 27% of the total amount of Igs ingested during the first day of life.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1983

[Occurrence and diagnosis of virus diseases of the gastrointestinal tract in calves in the Czechoslovakian SSR].

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Animals↗

PubMed1982

Teratogenic and clastogenic effects of BUdR in mice.

Pregnant mice (C57B1/6JFfm) were treated with BUdR on day 9 of gestation. For doses ranging from 300 to 1,200 mg/kg b.w. of BUdR the teratogenic effect in near-term fetuses was analyzed. The findings confirm the phase and dose dependency of the induced malformations found by other authors. They also demonstrate, however, a BUdR-specific induction of special malformations. For a dose of 1,200 mg/kg of BUdR the effect on mitotic rates and the induction of chromosomal aberrations were investigated. Mitotic rates were counted in single organs as well as in total homogenized embryos. The methods are equally useful. The embryos were analyzed 3, 6, 12, and 24 hours after BUdR treatment either after homogenization or in serial sections. Decrease of mitotic rates has been found to be most remarkable at 3 and 12 hours after treatment. At 24 hours only the neural tissue showed a slight decrease of the mitotic rate. Chromosomal aberrations are induced at all times, but the highest rates are seen at 3 and 12 hours after treatment. The aberrations are of the chromatid type.

Abnormalities, Drug-Induced↗

PubMed1982

[Diagnosis of bovine coronaviruses using mouse erythrocyte suspensions stabilized with formalin].

Bovine coronavirus isolated from calf faeces diseased with gastroenteritis and passaged to colostrum-free calves agglutinated mouse and rat erythrocytes. The agglutination reaction depended on temperature and took place only at a temperature of 4 degrees C. At a temperature of 37 degrees C the agglutinate broke down within 15 minutes. The coronavirus could be detected by the haemagglutination test in the contents of the small and large intestines and in the faeces of experimentally and naturally infected calves. The agglutination capacity of mouse erythrocytes was not affected by careful fixation of these erythrocytes with formalin and subsequent lyophilization and remained unchanged for as long as 52 weeks of storage at a temperature of 4 degrees C. It was demonstrated by a comparative examination of 182 samples of the faeces of calves suffering from diarrhoea that haemagglutination test was as sensitive as electron microscopy.

Animals↗