Biomedical subjects
J Foussereau
Publications and source records attributed to J Foussereau.
Allergy to MBT and its derivatives.
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[Complications and complexities of reading skin tests].
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[Various aspects of cosmetic allergy in Strasbourg].
Intending to determine the substances responsible in Strasbourg for allergies to cosmetics, we checked through all our cases from 1973 to 1980. Two main causes of the allergies were determined: Cosmetic cream and skin lotion (31.2% of cases) as well as nail enamel (20.8%). The importance of allergy to these enamels is notable compared with the extremely low figures found in the other countries (USA 1%, Sweden 6%).
Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig).
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Allergic contact dermatitis to plastic table cloth and phenyl indole.
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Contact dermatitis to phenylbutazone-piperazine suppositories (Carudol) and piperazine gel (Carudol).
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Patch testing with hexavalent chromium salts in different vehicles and with nickel and cobalt in petrolatum.
In approaching the question as to which test preparations are most suitable for patch testing of metals, 25 chromium sensitive patients were tested with 0.5% potassium dichromate either in water or petrolatum. The aqueous solution proved better than the petrolatum preparation at a 48 h reading with Neodermtest Roc. No difference in sensitivity was recorded between 4 hexavalent chromium salts. 3 patients who were only sensitive to chromium solution in water also reacted positively to a 1% cobalt chloride solution and a 5% nickel sulfate solution in petrolatum.
[Tropical woods and contact eczema].
An enquiry was carried out in Zaire among workers handling different woods. The aim of the investigation was to establish which woods provoke undesirable reactions of the skin and mucous membranes. Besides the well known toxic woods, 6 types of wood were identified, which had not been known to be cause of these reactions: --Autranella congolensis (dermatitis; ocular and respiratory manifestations); --Drypetes gossweileri (dermatitis; ocular and respiratory manifestations); --Ceiba pentandra (essentially pruriginous manifestations); --Diba di Nzambi (common name) and Ficus capensis (bullous dermatitis); --Combretodendron macrocarpum (dermatitis; ocular and respiratory manifestations).
[A case of allergy to dibutylthiourea caused by diver's footgear (author's transl)].
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[Irritation and allergy to acrylates and methacrylates. - Part I: Common monoacrylates and monomethacrylates (author's transl)].
Acrylates and methacrylates are industrial chemicals with insufficiently known irritating and allergenic effects. In this paper, the simple monoacrylates and monomethacrylates are considered. Methyl acrylate is an irritant, giving a reaction in 10 out of 30 patients, when tested at 20 p. 100 in olive oil. It is also an allergen (2 out of 22 cases). Because of its irritating properties, the concentration of 2 p. 100 is proposed for allergeric investigations. Methyl methacrylate, at 20 p. 100 in olive oil, is not an irritant for humans, although we have observed a sensitization rate of about 15 p. 100 with an undiluted product. In animal studies (technic of Kligman and Magnusson), 10 p. 100 of the subjects reacted to a working concentration of 1 p. 100 in petrolatum (allergenicity degree II). A risk of sensitization due to test repetition exists, about 9 p. 100 and 15 p. 100 for methyl acrylate (20 p. 100) and undiluted methyl methacrylate, respectively. For the latter, sensitization appears around the 16 th-18th day and may be preceeded by an irritation (1 out of 3 cases). Allyl acrylate and allyl methacrylate are irritants which should be studied at a concentration of about 0,1 p. 100. A 5 p. 100 concentration in olive oil seems appropriate for studying allergies to the following monoacrylates and monomethacrylates: acrylamide and acrylonitrile, n-butyl, cyclohexyl, ethyl, ethyl-2-hexyl, ethoxy-2-ethyl, phenyl acrylates, cyclohexyl dodecyl, ethyl-2-hexyl, ethoxy-2-ethyl, methyl methacrylates.
[Irritation and allergy to acrylates and methacrylates. - Part II: Polyfunctional acrylic monomers (author's transl)].
Acrylates and methacrylates are industrial chemicals with insufficiently known irritating and allergic effects. After considering simples monoacrylates and monomethacrylates, this paper deals with the n-ethyleneglycol acrylates and methacrylates and some polyol polyacrylates and polymethacrylates. All of the diacrylates tested are irritants for humans at 3 p. 100 in olive oil but there is no irritation at 0,1 p. 100. Monomethacrylate and dimethacrylate are not irritants at 3 p. 100 in olive oil. Studies with animals confirm that diacrylates are more irritating than dimethacrylates and the Magnusson and Kligman method shows that the substances induce delayed hypersensitivity. Cross reactions were observed in homogeneous series (diacrylates or dimethacrylates) but not between series. These results are in good agreement with clinical observations. The irritating power of 5 polyacrylates and polymethacrylates of other polyols were tested in animals. For some of them, clinical observations indicate an allergic potential.
[Investigation of contact allergies in 100 cases of ulcus cruris (author's transl)].
In a group of 100 patients with ulcus cruris, the incidence of contact allergies was determined. Patch tests were applied with 18 products that might have come into contact with the skin. These products comprised drugs and excipients (preservatives and ointment vehicles) potential ingredients of tapes or of elastic bandages. Peru balsam (14%), wool-wax alcohols (10%), Nestosyl owing to its para-aminobenzoate component (7%), neomycin (5%) and Thyme oil (5%) were the allergens most frequently encountered.
Eau de Javel and prevention of chromate allergy in France.
"Eau de Javel" (liquid bleach) is a common cause of chromate contact allergy. A historical review explains the reasons for the addition of sodium dichromate after the First World War. The chromium content in different brands of eau de Javel has been determined by flameless atomic absorption spectrophotometry. The results indicate that the chromium content is very low (0.03--3.65 mg/l) in French brands, whereas it is still important (7.06--82.9 mg/l) in Belgian brands, such an observation indicates that the almost complete removal of chromate in most brands of French eaux de Javel is a good example of prevention in the field of contact dermato-alllergology.
Cross-sensitivity between aminoside antibiotics.
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Is hair dyed with PPD-like dyes allergenic?
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Contact dermatitis in children.
It is generally admitted that contact dermatitis seldom appears in children. Eighty-seven cases, however, have been diagnosed at the Department of Allergology of the Dermatological Clinic in Strasbourg in the past 10 years (1969-1978). No element of atopic diathesis could be found in any of them. We have reviewed the cases with a positive patch test to try to derive both theoretical and practical conclusions.
[Contact allergy to N-isopropyl N'-phenylparaphenylenediamine (IPPD) in different individual protective devices (author's transl)].
N-isopropyl N'-phenylparaphenylenediamine, a known sensitizer, is searched for in different elastomeric formulations. Systematic chemical analysis as well as clinical investigations have been performed, especially on gloves, boots and respiratory protective devices. Some cases remain unaccounted for: some IPPD-sensitized people do not react to the contact of objects containing IPPD, other react to objects in which even thorough analysis failed to detect this compound. A better knowledge of the allergologic profile of sensitized people and better analytical detection limits might be desirable.