Biomedical subjects
Publications and source records attributed to J Feit.
Focal nonhemorrhagic lesion in the splenium of the corpus callosum in a patient with epilepsy treated with antiepileptic drugs was observed with MRI imaging. We have found only one such case during the past 2 years (series of MRI examinations of approximately 500 patients with various forms of epilepsy).
We prepared a digital atlas of non-tumourous skin pathology. Currently, the available digital atlases can go beyond the scope of written publications, especially with regards to ease of access, speed of preparation, updating information, fair price and unlimited capacity. This atlas can be used as a diagnostic aid, as well as for postgraduate and pregraduate teaching.
Gastric carcinoma is an extremely rare cancer in children. A case is presented of a 9-year-old boy admitted to The University Hospital Brno with a 4-month history of abdominal pain, anorexia, weight loss, nausea, and vomiting. Several of his family members died from or have been treated for cancer. Barium meal examination performed 2 months prior to admission was nondiagnostic. When gastroendoscopy, laparoscopy, and abdominal computer tomography scan were performed, the diagnosis of adenocarcinoma of the stomach was established. The patient died 10 days after admission because of rapid cancer spread. Miliary metastases of the peritoneum, mesenterium, omentum, liver, bowels, lungs, heart, bone marrow, and skin were found. No penetration through the hematoencephalic barrier was noticed.
A teaching database for pathology was prepared comprising around 1250 questions. Five answers belonged to each question, only one of them being correct. Preparation of questions was partly based on testing sets from Medical School of the University of Loma Linda, Ca., partly on those used in 2nd Department of Pathology, Masaryk University Medical School, Brono. In addition, set of computer programmes for automatic generation, printing and evaluation of tests was prepared. They were verified with Brno students.
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Neonatal micropolygyria (MG) was studied concerning a possible proportion of neuroblastic migration in its formal pathogenesis. Section of three selected groups of neonatal brains yielded complete series of frontal histotopograms. Findings were compared with experimental MG induced in the period of neuroblastic migration. Group A: Registration of residual neuroblastic migration in cerebral cortex. There was found that the residual migration could participate on production of MG as late as in the 27th week of gravidity (weight of 1000g). Group B: Evaluation of neuroblastic migration in partial necrosis. Migrating neuroblasts were found in neonatal cerebral cortex with hypoxic encephalopathy. A correlation existed with experimental data proving that MG neonatal cerebral cortex could be produced by neuroblastic migration through fields of partial necrosis. Group C: Detailed investigation concerned 4 neonates with MG due to hypoxic necroses- 2 cases with probable lesion of big vessels perfusion after thromboembolia and 2 cases with cortical vessels perfusion lesion in toxoplasmosis and rubella meningoencephalitis. Findings were compared with experimental MG and correlated with the data from group A and B. Results showed that the production of MG formations in neonatal brain (atypical irregular MG cortex, 4-layer-MG cortex, intracortical nodules, MG intracortical microsulci, neuronal protrusion into molecular layer and pia mater, intracortical and subcortical neuronal heterotopias) can be participated by neuroblastic migration in the transformation of injured immature cerebral cortex. Probable timing of various MG formations and of a relation of MG to ulegyria were presented.
Description of a database system for registration of biopsies in a IBM-PC (AT) compatible computer. The system enables simple registration of bioptic findings for needs of diagnosis, teaching, seminars, and research.
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Leukocyte adherence inhibition (LAI) assay was employed to detect cell-mediated immune response in breast cancer patients of clinical stages I and II. Twenty-one breast cancer extracts were screened in 232 breast cancer patients and 343 healthy persons. The activity of individual extracts differed remarkably. Overall, LAI response was 58.6% (136/232) correct and 18.9% (65/343) false positive. Fifteen extracts were not suitable from the clinical point of view. Only two extracts gave a constantly high rate of tumor-specific LAI-positive values in breast cancer patients, ie, 83.3% (25/30) and low percentage of false positive results in controls, ie, 4% (2/50). A further study dealt with the possible relation between the activity of extracts (expressed in percentage of positive LAI results in the tumor group) and histology of primary tumor of patients whose tumor tissue was used for extraction. This relationship could not be proven statistically. We investigated also whether the percentage of correct LAI responses in breast cancer patients could be affected by histological agreement or disagreement (grading and node involvement) between primary tumor of extract donor and primary tumor of patients tested. No significant relationship was found in this respect.
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Tumor "specific" immune recognition was assayed in 125 patients with various breast diseases including breast cancer of clinical stage I and II, 22 patients with other malignancies and 64 healthy persons employing leukocyte adherence inhibition test (LAI). In the group of breast cancer patients (BC) there were 81% of positive responders (52/65) with a mean nonadherence index (NAI) value 67.4. Sensitization to extract derived from breast cancer was detected in 38.3% (23/60) of patients with benign breast diseases (BBD). The mean NAI value was significantly lower comparing to NAI value of BC patients (34.8 vs. 67.4) but exceeded the upper limit of normal values. The most frequent positive responders of BBD group were found in patients with proliferative mastopathy (11/17). Our study brought further evidence that BC patients and in a lesser degree BBD patients are sensitized to some antigen(s) contained in selected breast tumor extracts. However, high proportion of false positive results in healthy persons (14.1%) and mainly considerable number of positive responders in BBD patients represent a major limitation for clinical diagnostic usefulness of the LAI assay.
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Using the histochemical reaction for the demonstration of TPPase the shape and distribution of the Golgi apparatus (GA) of the ventricular zones of the CNS of rats was studied during embryonal and postnatal development. In the cells of the ventricular zone of the spinal cord, the Hypothalamus, the Thalamus, the N. caudatus and the Cerebral cortex two forms of GA can be distinguished: Form 1 GA has the shape of small rods or grains placed in the ventricular process of the cell at various distances from the nucleus. In the spinal cord and the Hypothalamus the 1st form correlates with the period of neuroblastic production, and the same correlation probably exists in other regions of the CNS also. Form 2 GA is in sequence with form 1; it is characterized by a large beam shape, situated supranuclearly near to the nucleus. The relation of form 2 to gliogenesis is discussed. In the alar region of the spinal cord only form 1 GA occurs. The GA of cells of the subventricular zone has on average a lower enzymatic activity than that of the ventricular zone. By day 18 intra uterinam the subventricular cells have the shape of very small grains (1 micron) or are not visible. From day 18 intra uterinam cells with a large GA begin to appear and steadily grow in number until postnatally they form the majority of the subventricular layer. Autoradiographical investigation and a comparison with published data showed that cells without GA and with discrete GA are stem cells and those with a large GA are glioblasts. Glioblasts are arranged in the subventricular zone with the GA pointing in the direction of migration. According to the ratio of glioblasts and stem cells topographical regions can be divided into early, transitional and permanent phases of glioproduction. The gel method of demonstrating TPPase is highly suitable for study of the differentiation of the CNS and for observing the progress of glioproduction.
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