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Biomedical subjects

J Faintuch

Publications and source records attributed to J Faintuch.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

[Infections of central venous catheters].

The central venous catheter is considered the lifeline of patients requiring long-term parenteral nutrition, and its infectious complications accordingly represent a frequent cause for hospitalization and morbidity. Modern catheters made of Silastic increase the duration and efficiency of venous access, but their substitution is also more complex and expensive. In a small series of patients undergoing home parenteral nutrition due to short bowel syndrome, and carrying. Silastic catheters, infection of the cannula was treated by administration of systemic as well as local antimicrobial agents. The septic process was resolved without the need of removing the catheters, and with excellent tolerance to the medications. It is concluded that in-situ sterilization of long-term catheters should be attempted in selected cases.

Adult↗
PubMedDate not supplied

[The prognostic value of cholesterol levels in malnourished patients with esophageal carcinoma].

A variety of clinical calculations, including serum cholesterol, have been used as parameters of prognostic value in surgical populations, but there are few studies aimed at patients with esophageal carcinoma. In a set of patients with established esophageal cancer, cholesterol and triglyceride levels were recorded, along with the following parameters: age, sex, body weight, serum albumin, total lymphocytes, and hemoglobin concentration. Manual grip strength was measured, along with delayed cutaneous hypersensitivity response, and the type of surgical treatment was distinguished (palliative versus radical). Total complications and postoperative hospitalisation time are the main indicators used in our study for the surgical results. Patients were divided into two groups: those with serum cholesterol levels over 150 mg/dl (Group I) and those under that figure (Group II). Most nutritional and functional values were lower in Group II patients, for whom the radical surgery rate was also lower, with greater postoperative morbidity. It was concluded that 1): Cholesterol depletion is associated with nutritional and immunological alterations and 2) post-surgical results are poorer in patients with levels below 150 mg/dl.

Adult↗
PubMedDate not supplied

[Nutritional support, free radicals, and antioxidants].

Antioxidants and free radical scavengers are molecules endowed with the ability of neutralizing reactive oxygen species that may accumulate in the organism during various pathologic processes. In circumstances of peroxidation of lipids and damage to enzymatic chains, cell membranes and other structures may be followed by functional losses and even cell death. Many antioxidants are normal constituents of the diet in the form of vitamins, trace elements and amino acids, and other useful properties cannot be easily distinguished from their free-radical scavenging abilities. Much controversy surrounds also the indications of these substances, both for prophylactic and therapeutic purposes. The first large-scale population studies have only recently been arranged, and additional investigations are required in many promising areas, including cancer patients undergoing chemo and radiotherapy.

Antioxidants↗
PubMedDate not supplied

[Comparative study of arginine and glutamine supplements in malnourished surgical patients].

Protein-calorie malnutrition is frequently diagnosed in patients with serious digestive conditions displaying obstructive symptoms, notably in esophageal cancer. In the present study a homogeneous group of subjects affected by esophageal cancer and candidates for elective surgery was randomly treated by one of the following oral supplements: arginine (group I), glutamine (group II), or mixed commercial amino acids (Group III-controls). The methods included nutritional measurements (biochemical and anthropometric assement), immunologic survey (skin tests), and general clinical and surgical findings, with emphasis on surgical morbidity. Body weight remained stable throughout the study, whereas serum albumin, total lymphocytes and skin tests tended to improve in all groups, with statistical confirmation for albumin in arginine-treated cases (group II). Post-operative hospitalization was numerically shorter during glutamine supplementation, and this trend was statistically significant when total morbidity was compared between the groups. It is concluded that: 1) Malnutrition and anergy were a major problem in this population, with equally severe post-operative morbidity; 2) Administration of arginine enabled serum albumin levels to improve; 3) Glutamine-treated subjects displayed reduced post-operative morbidity; 4) No side effects could be attributed to the therapy here employed.

Adolescent↗
PubMedDate not supplied

[Iron-deficiency anemia in enteral nutrition: correlation with tube position].

Enteral alimentation is a commonly employed procedure for pre-operative rehabilitation and nutritional maintenance of depleted patients suffering from esophageal diseases. In a prospective study of 61 cases exhibiting benign (n = 38) and malignant (n = 23) conditions, a commercial polymeric diet was supplied in the proportion of 40 Kcal/kg/day during at least two weeks. The liquid preparation was infused by bolus technique at home, by the patients themselves, via nasogastric (n = 25) or nasoduodenal silastic tube (n = 36). Total food intake, that before treatment had been under 60% of estimated requirements, reached the expected range throughout the therapeutic period, and also iron input was adequate (0.3 mg/kg/day). Standart anthropometric and biochemical assessment of these cases, with included serum iron and hemoglobin concentration, indicated stabilization of general nutritional parameters, but with persistence of moderate anemia(hemoglobin 12.6 +/- 2.0 g/dl; iron 59.2 +/- 35.7 mg/dl). Stratification of the population according to enteral tube position demonstrated similar diagnoses and clinical conditions for both groups. Mean initial iron and hemoglobin concentration was also the same, but final serum iron was increased after gastric administration (p < 0.05) and diminished with duodenal diet (p < 0.05). It is concluded that: home enteral nutrition in malnourished patients with esophageal diseases is consistent with an acceptable nutritional status, but without significant recovery from anemia, serum iron in this population only increases after intra-gastric alimentation; it is probable that this last finding is related to impaired ionization and absorption of dietary iron, when food is introduced in a postpyloric site.

Anemia, Iron-Deficiency↗
PubMedDate not supplied

[Cardiovascular effects of arginine and nitric oxide].

Amino acids are an unusual chemical category because they are endowed with alimentary properties, but at the same time they may determine typical pharmacologic responses in some circumstances. These facts were responsible for the origin of modern pharmaconutrition, which has been using arginine for some time because of its beneficial impact on immune function, nitrogen anabolism and wound healing. The recent identification of its metabolite NO (nitric oxide), a powerful mediator related to a large number of physiologic and pathophysiologic phenomenons, has augmented the interest for this amino acid.

Animals↗
PubMedDate not supplied

[Nutritional assistance to patients during radiotherapy].

With the aim of assessing the possible benefits of nutritional therapy, 140 patients were prospectively studied during radiotherapy of the head and neck (81%) and esophageal cancer (19%). Mean age was 56.0 (17-80), with 114 males and 26 females. Duration of both nutrition and radiotherapy was 78.0 +/- 45 days. Tube feeding was the primary modality in 50.7% of the population, and oral regimens in the remaining 49.3%, but associations between the methods were also used. Enteral diets were supplied under the supervision of a specialized tem for home alimentation (PROSNED). Compliance to the program was 100%, and a lymphocyte count diminished along this period (1933 +/- 1033 vs 1265 +/- 688, p. 0.001). A subjective improvement was reported by 84% of the population, and total calorie intake, that was below 60% of estimated needs in 100% of the cases initially, significantly improved to just 40% inadequate at the end of the observations. Radiotherapy was associated with mucositis in 21% of the patients, taste changes in 79%, xerostomy in 81%, anorexia in 66% and odinophagia in 59%. In the individuals selected for enteral feeding, side-effects were represented by technical problems (20%) and gastrointestinal disorders (13%). All patients completed the nutritional support program and there was no mortality in this series. It is concluded that; 1) Early nutritional support during radiotherapy was able to maintain or improve the nutritional status; 2) Tube feeding, alone or in combination with oral diets, was indicated whenever appropriate and contributed to fulfillment of the energy requirements; 3) Reduction of total lymphocytes could not be prevented by the mentioned therapy; 4) Complications of enteral alimentation were mild and affected a small proportion of the population; 5) Troubles induced by radiotherapy were as frequent as expected, and tended to disturb the intake of food; 6) The compliance to the therapeutic plan was excellent and can be attributed to the efforts of the multidisciplinary team as well as to the help of the specialized home alimentation unit (PROSNED): Diet therapy. Cancer. Nutritional assessment. Radiotherapy. Nutritional support.

Adolescent↗
PubMedDate not supplied

Hematologic disorders in trauma patients during parenteral alimentation with lipids.

Total parenteral nutrition with lipids is a well-accepted modality of metabolic support in seriously ill trauma patients. Intolerance to lipid administration is unusual when dosage limits are not exceeded, and few hematologic disturbances have been recorded with modern fat emulsions. In the course of intravenous alimentation of six adults admitted for traumatic lesions, eosinophilia with or without leukocytopenia was noticed after periods of four days to five weeks. Principal clinical events and hematologic derangements were documented in this population. Sepsis was not always present in the patients by the time of the complication, and in those that did require antibiotics and other drugs, the prescription remained unchanged along the episode. Discontinuation of the nutritional regimen with lipids was followed by normalization of the hematologic profile, suggesting that an acute or sub-acute allergic reaction was responsible. The appearance of skin rash in two occasions reinforces this hypothesis, and the possibility of hemophagocytosis merits consideration in two of the cases who displayed reversible acute leukocytopenia. It is concluded that blood cell aberrations are possible during intravenous feeding with lipids in trauma subjects, but tend to respond to suppression of the lipid-containing nutritional prescription.

Adolescent↗