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Biomedical subjects

J F Jimenez

Publications and source records attributed to J F Jimenez.

46 records · Page 3Linked to original sources
PubMed1981

Testicular leydig cell hyperplasia as a cause of familial sexual precocity.

Testicular Leydig cell hyperplasia was observed in two brothers presenting with progressive sexual precocity at 2 yr of age. Virilization was shown to result from increased secretion rather than decreased clearance of gonadal testosterone. Testosterone hypersecretion appeared to be gonadotropin independent, as basal and gonadotropin-releasing hormone-induced serum LH concentrations were low by both RIA and bioassay. Adrenal steroidogenesis was demonstrated to be normal by ACTH stimulation, dexamethasone suppression, and split adrenal venous function tests. Testicular histology revealed immature reproductive structures in the 2 yr old, but advanced spermatogenesis in the 3 yr-old brother. The etiology of both Leydig cell hyperplasia and reproductive testicular maturation in the absence of significant gonadotropin secretion remains to be established.

Child, Preschool↗
PubMed1981

Melanotic neuroectodermal tumor of infancy and fetal hydantoin syndrome.

Fetal hydantoin syndrome (FHS), a characteristic pattern of altered growth and development, has been well described in recent years in offsprings of epileptic mothers taking phenytoin or other hydantoin anticonvulsants during the gestational period. Recent reports of neuroblastoma in three patients with the FHS further raise the questions of the "oncogenic effect " of hydantoin compounds. A case of melanotic neuroectodermal tumor of infancy (MNTI) has been studied clinically and pathologically including light microscopy, histochemistry, and electron microscopy. This case strengthens the evidence for the teratogenic and oncogenic effects of hydantoin compounds and we believe that it represents the first reported case of FHS associated with MNTI. It would be most important from a clinical standpoint to carefully scrutinize individuals with the FHS for neoplasias. Furthermore, detailed gestational drug history in children with neuroblastoma and other neoplasias should be carefully searched for, with the hope of clarifying the definitive oncogenic effect of hydantoin compounds.

Abnormalities, Drug-Induced↗
PubMed1978

Treatment of pyonephrosis: a comparative study.

Our study is a comparison of treatments used for 97 patients with pyonephrosis. The patients were divided into 3 groups: 1) cases in which a primary nephrectomy was done, 2) cases in which nephrectomy was secondary to drainage through a nephrostomy and 3) cases in which nephrectomy was secondary to drainage through a translumbar percutaneous puncture with an Ingram catheter indwelling. Patients in whom nephrostomy and puncture were used had the highest percentage of complications, while primary nephrectomy produced the best results. Therefore, we believe that primary nephrectomy is the procedure of choice, using drainage through a puncture only when the general status of the patient does not permit primary nephrectomy.

Drainage↗
PubMed1977

Impotence and diabetes mellitus.

Impotence is a rather frequent symptom in the diabetic patient. The aetiology of this problem is not clear. Urodynamic and hormonal examinations have been performed in a group of 10 diabetics with impotence in order to evaluate its neurogenic and endocrine factor. The determination of the parameters that effect micturition are dependent on the erector nerve, which at the same time participates in erection, demonstrating the existence of a neuropathy of the erector nerve and shows if it is responsible for the impotence. The hormonal examinations were all normal. The different urodynamic alterations which have been found are tabulated and the importance of a simple determination of voiding time, as a proof in the screening of these patients, is emphasized.

Adult↗
PubMed1977

Anorchi.

Anorchia was diagnosed in 3 patients after a hormonal study entailing the basic determination of FSH, LH and testosterone by a radioimmunoassay technique and by later stimulation with HCG. 2,000 IU are administered during 3 consecutive days with a new testosterone determination 24 and 72 h after the last administration. If the result is negative, the test is repeated but the HCG dose is doubled. A new negative response confirms the diagnosis of anorchia. If the results are positive a spermatic phlebography allows localization of the testicles or the remains of Wolffian origin in order to simplify surgery.

Adolescent↗
PubMed1975

Preliminary report of an immunological study in urological cancer.

In this study, 32 cases of cancer of the genito-urinary tract are discussed from the viewpoint of immunology. In eight cases treated surgically, there has been no evidence of recurrence over a period of 1-4 years. Those with a good immunological response have a satisfactory course. Patients with a good response have been treated by radical surgery depending on the stage of the tumour, whilst those with a poor response have been treated less radically by reduction of the tumour mass in the hope that a better response may develop. The authors of this report feel that the 'inhibition of the lymphocyte migration test' is a very important factor to evaluate in the study and immunological evolution of the patient. Also, and concerning cases with good immunological response, the poor results after surgery makes us consider the importance and value of blocking factors of the serum closely related to the B type lymphocytes.

Female↗
PubMedDate not supplied

The caudal regression syndrome in infants of diabetic mothers.

Ultrasonography as part of the pre-natal diagnosis in high risk pregnancies may detect a number of fetal malformations that need to be re-evaluated for continuation or termination of pregnancy. Two fetuses, in two different patients with diabetes mellitus, were found to have significant intrauterine malformations detected by ultrasonography at 18 and 20 weeks gestational age, respectively. Post-mortem examination on both fetuses demonstrated the findings known as the caudal regression syndrome. The clinico-pathological features and obstetrical management of diabetic mothers whose pregnancies are complicated with this rare malformation are discussed.

Abnormalities, Multiple↗
PubMedDate not supplied

[Renal heamangioma (author's transl)].

Two cases of renal haemangioma. The literature is reviewed, 150 cases being presented. The aetiology is variously taken to be a tumour or malformation. The predominant clinical sign is haematuria. The authors stress the difficulty of making the diagnosis preoperatively. Amongst the various histological types, the cavernous variety is the most common. Treatment is essentially surgical though radiotherapy has centain indications.

Female↗