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Biomedical subjects

J F Jimenez

Publications and source records attributed to J F Jimenez.

At least 37 records · Page 2Linked to original sources
PubMed1985

Spurious elevated platelet counts associated with bacteremia.

Spuriously elevated automated platelet counts secondary to in vivo bacteremia have not been reported previously. Two patients are described with blood cultures positive for Escherichia coli and Klebsiella pneumoniae, respectively, and bacteria present on peripheral blood smear. Those bacteria caused falsely elevated platelet counts to be generated by the Ortho ELT-8. These cases illustrate an unusual artifact and demonstrate that spurious counts can be generated by laser optical blood cell counters.

Adult↗
PubMed1985

Acute cytoreduction techniques in the early treatment of hyperleukocytosis associated with childhood hematologic malignancies.

Early and effective cytoreduction for high peripheral white blood cell counts in pediatric patients with acute leukemia may be helpful in preventing complications secondary to hyperviscosity. It also may be a useful adjunct to systemic chemotherapy. As an alternative to automated apheresis for this purpose, manual exchange transfusion is efficacious and does not require hemapheresis instrumentation and disposables and the related special staff. Two patients, a neonate with acute myeloblastic leukemia and a white blood cell count of 422.2 k/microliter as well as a 2 1/2-year-old with an admission diagnosis of acute promyelocytic leukemia and a white blood cell count of 617.4 k/microliter, underwent manual exchange hemotherapy for acute cytoreduction. The procedures were tolerated well, and significant leukocyte removal was achieved, with the respective leukocyte reductions being 81.1 and 68.7%. The techniques available for pediatric cytoreduction are compared, with emphasis on their efficiency and safety and appropriateness for very small children.

Acute Disease↗
PubMed1985

Primary intracranial immunoblastic lymphoma in infancy.

Primary intracranial lymphoma is uncommon in any age group, but it is especially rare in childhood. This report describes a previously healthy, 14-month-old female infant who developed a primary intracranial immunoblastic (probable B-cell) lymphoma which remained confined to the central nervous system until the time of death, 23 months after diagnosis. She appears to be the youngest patient with documentation of such a diagnosis by light and electron microscopy and by histochemical and immunoperoxidase studies. An immunological investigation was negative. Significant maternal and paternal family histories of malignancy suggest that a genetic predisposition, combined with postzygotic events such as viral infection, may be responsible for this familial cluster of tumors, and for this patient's unusual presentation.

Brain Neoplasms↗
PubMed1984

Megacystis-microcolon-intestinal hypoperistalsis syndrome: case report and review of the literature.

We report a case of the megacystis-microcolon-intestinal hypoperistalsis syndrome and review the literature. Generally, this disease affects female neonates and is usually fatal within the first year of life. All patients have microcolon megacystis, intestinal hypoperistalsis, abdominal distention and dilated small bowel. Although the dilated bowel and urinary tract suggest an obstruction, such is not usually the case and surgical intervention is not always necessary. The abdominal distension results primarily from distension of the urinary tract.

Colon↗
PubMed1984

Rhinosporidiosis. A report of two cases from Arkansas.

Two human native cases of ocular-conjunctival rhinosporidiosis from Arkansas are believed to be the first documented reports in this part of the country. The common mode of infection was accidental injury to the eye by possible contaminated soil-dust. The appearance of the polypoid growth was relatively fast, 6-16 days, and unresponsive to topical antibiotic and steroid treatment. Surgical excision, with one recurrence in one case, was the elective treatment. Both patients are asymptomatic 10-12 months after treatment, respectively, with no evidence of other recurrence, dissemination, or major complications. From 1939 to September, 1983, only nine cases of conjunctival rhinosporidiosis were reported in the United States.

Adult↗
PubMed1984

Cranial sonography: anatomic and pathological correlation.

Through the acoustic window of the anterior fontanelle, coronal and parasagittal sonograms of the infant and premature neonate are easily obtained. Supplementary axial images are obtained through the lateral skull vault. The normal anatomy of axial, coronal, and sagittal sonograms will be demonstrated by correlating normal infant brain images with cadaver brain slices at similar levels. The relevant anatomical structures will be identified and labeled. Pathological entities, i.e., intracerebral hemorrhage, brain tumors, arteriovenous malformations, hydrocephalus, and congenital malformation syndromes will be included. Neonatal ultrasound is an inexpensive, innocuous, and noninvasive technique for examining the brain of the newborn infant. It does not require sedation and can be performed either within the radiology department or in the newborn intensive care unit.

Brain↗
PubMed1984

Nasopharyngeal brain heterotopia--a cause of upper airway obstruction in infancy.

The finding of mature neuroglial tissue in a mass from the head and neck region of a child raises four differential diagnostic possibilities: teratoma, encephalocele, glioma, and heterotopic brain tissue. We present a review of the literature and discuss the clinical, radiographical, and pathological features of a rare nasopharyngeal brain heterotopia in an infant causing upper airway obstruction.

Airway Obstruction↗
PubMed1983

Renovascular hypertension in an infant with segmental renal artery stenosis and hypoplasia of the abdominal aorta.

Hypoplasia of the abdominal aorta is a rare cause of renovascular hypertension. Arteriographic studies of the renal vasculature are presented from an infant with hypoplasia of the abdominal aorta and segmental renal artery stenosis. The renovascular hypertension was cured by partial nephrectomy. There was no difference in the parenchymal histology in the tissue from the congenitally ischemic lower pole of the kidney and the vascularized upper pole. In this unique case with decreased renal blood flow during fetal development there was no evidence that parenchymal ischemia can cause renal parenchymal hypoplasia.

Aorta, Abdominal↗
PubMed1983

Sonographic recognition of multiple cystic encephalomalacia.

Multiple cysts in both hemispheres were detected in four children under 1 year of age by real-time sonographic sector scanning. These cysts, typical of multiple cystic encephalomalacia, followed viral encephalitis in two, bacterial meningitis in one, and bacterial meningitis superimposed on intracerebral hemorrhage in one. The diagnosis of multiple cystic encephalomalacia, which has a grave prognosis, is readily made with high-resolution real-time sonography.

Brain↗
PubMed1983

Chronic camphor ingestion mimicking Reye's syndrome.

Camphor is a potentially dangerous drug which nevertheless remains popular as a home remedy. Because of its hepatoneurotoxic effects, camphor toxicity may clinically mimic Reye's syndrome. The differentiation between the two requires histologic examination of liver tissue, further emphasizing the need for a liver biopsy to establish the diagnosis of Reye's syndrome.

Biopsy↗
PubMed1982

Lymphoid polyps (focal lymphoid hyperplasia) of the colon in children.

Lymphoid polyps (focal lymphoid hyperplasia) of the colon are rare in children. These lesions are benign, but must be differentiated from malignant lymphomas. Grasp biopsies of the lesion are inadequate for this purpose and the polyp should be submitted in toto for pathologic examination. No treatment other than local excision is warranted. Two cases are presented and the literature is reviewed.

Adolescent↗
PubMed1982

The histopathology of camptomelia (bent limbs). A dyschondrogenesis.

Camptomelia is well established syndrome in which the most prominent osseous feature is bowing of the long bones. Although several patients have died, usually due to respiratory insufficiency caused by defects of the cartilage of the tracheal rings and lower respiratory tract, histologic studies of the bone in camptomelia have led to conflicting conclusions about pathogenesis. A complete autopsy of a neonatal case, including serial sections of the long bones, revealed normal enchondral growth sequences of the epiphyseal plate. In the diaphysis, centering around the angle of the bend, the cylinderization process was markedly abnormal. Extensive new secondary trabeculae formed on the concave (posterior) surface of the bone during resorption on the convex (anterior) surface. A cone of dense new bone formed at the apex at the convex anterior angle of the bend. These findings supported previous suggestions that bone formation and remodeling processes were normal. With the variation of bone involvement in different patients, these features indicate that camptomelia is the result of an abnormality of cartilage anlage formation, probably owing to a transient exogenous teratogen. Camptomelia is the preferred term. Basically, the syndrome is a dyschondrogenesis.

Bone and Bones↗
PubMed1981

Neonatal myotubular myopathy: neuropathy and failure of postnatal maturation of fetal muscle.

The natural course of the pathologic features in striated muscle was studied in a full-term infant with myotubular myopathy. At 5 days of age a muscle biopsy revealed that more than 90 percent of muscle fibers fulfilled histologic, histochemical and electron microscopic criteria of fetal myotubes. The infant died unexpectedly at 9 months of age from spontaneous rupture of a multifocal cavernous hemangioma of the liver. Postmortem examination revealed that progressive maturation of the fetal muscle had not occurred postnatally, and more than 90 percent of myofibers were still apparent myotubes. This maturational arrest was generalized to all striated muscles. The only changes detected since the neonatal period were hypertrophy of the small population of large fibers, but with minor cytoarchitectural alterations, and loss of the incomplete histochemical differentiation with ATPase stains or dedifferentiation not attributed to postmortem diffusion. Involvement of the gubernaculum testis accounted for the undescended testicles. The brain and spinal cord appeared normal. Evidence of degenerating and regenerating axons in the sciatic nerve suggested that the etiology of this maturational arrest of fetal muscle may be neurogenic.

Aging↗