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Biomedical subjects

J Erikssen

Publications and source records attributed to J Erikssen.

At least 127 records · Page 7Linked to original sources
PubMed1980

ABO blood groups and coronary heart disease (CHD). A study in subjects with severe and latent CHD.

The view based on epidemiological and laboratory data that blood group A subjects (=A) have clinically significant higher thrombotic potential than blood group 0 subjects (=O), is supported by the present finding of a significantly higher platelet retention in A than 0. The completely normal AB0 distribution found among 71 cases of proven latent CHD, and the disproportionate excess of 0 vs. A in a consecutive series of 191 coronary artery bypass candidates apparently conflict with epidemiological data indicating a higher risk of achieving CHD in A than 0. The conflict may be solved by suggesting a) that the "thrombotic proneness" in A compared with 0 causes a poorer prognosis in CHD among the former, leaving a disproportionate excess of 0 among longterm CHD survivors, and b) that AB0-related factors have had an insignificant, independent impact on the evolution of preclinical coronary artery disease in our 71 men with latent CHD.

ABO Blood-Group System↗
PubMed1980

The relation between the levels of HDL cholesterol and the capacity for removal of triglycerides.

In twenty-two men with "normal" findings clinically, by exercise ECG and laboratory tests, we performed an i.v. fat tolerance test, measurement of LCAT activity and the activities of post-heparin triglyceride lipases, and estimated serum lipids. HDL cholesterol was positively correlated to lipoprotein lipase (r=0.50, p < 0.05) and to the fractional removal rate of exogenous fat (r=0.59, p < 0.01), and negatively to the fasting levels of triglycerides (r=-0.65, p < 0.01). LCAT was neither correlated to HDL cholesterol nor to the fat removal rate. Our reseults confirm that a high triglyceride removal capacity is closely correlated to a high level of HDL. The association between the catabolism of triglyceride-rich lipoproteins and HDL was thus further substantiated.

Cholesterol↗
PubMed1980

Blood pressure responses to bicycle exercise testing in apparently healthy middle-aged men.

1,678 normal males between 40 and 60 years of age were subjected to a near maximal bicycle exercise test. 1,309 reached 90% of the maximal predicted heart rate. Data given for blood pressure, pulse responses and work capacity. The group which did not reach 90% of the maximal predicted heart rate had lower resting pulse and blood pressure, lower work capacity and showed a smaller rise in systolic blood pressure during work. The results may be used as a standard for normal blood pressure response during near maximal exercise.

Adult↗
PubMed1979

Resting heart rate in apparently healthy middle-aged men.

Resting heart rate (fcrest) was measured by a standardized technique in 2,014 men aged 40-59 years during a cardiovascular survey. All men were thought to be healthy prior to the survey examination. According to the survey findings, the material was subdivided into 5 clinical subgroups, according to survey findings of coronary heart disease (CHD), or suspect symptoms, or signs. Coronary angiography was performed in 105 subjects with particularly strong suspicions of CHD. FCrest varied between 61-63 among the 5 groups (p greater than 0.10). In 1832/2014 defined as "normals" the following findings were made: 1. Mean fcrest 61 (SD 9.7), and almost identical values obtained by auscultation and from resting ECGs in the same persons. 2. Linear drop in fcrest by age (-0.126 beats/year, p less than 0.001). 3. Increase in fcrest with increasing systolic blood pressure. Since there is no generally accepted technique for measuring fcrest it is suggested that the wide variation in fcrest reported in the literature at least in part may be due to differences in techniques.

Adult↗
PubMed1979

Seasonal variation in work performance and heart rate response to exercise. A study of 1,835 middle-aged men.

A near maximal bicycle exercise test in 1,835 presumably healthy Norwegian men indicated a seasonal variation in physical fitness. Thus, the total amount of work performed was significantly higher, and the work pulse on equivalent loads significantly lower during the summer than during the autumn. Although the differences were small, they may invalidate comparisons made between exercise tests in populations tested at different seasons of the year. In particular, there was a considerable and sudden change in the above mentioned parameters from June--August to September--October.

Adult↗
PubMed1979

High density lipoproteins, insulin secretion and coronary risk factors in latent coronary insufficiency.

Coronary heart disease (CHD) risk factors were studied in presumably healthy men, examined for preclinical CHD. Coronary angiography was performed in most "latent CHD" subjects. High density lipoprotein (HDL) cholesterol and apoproteins did not differ significantly between men with latent CHD (some with angiographic changes) and men without evidence of CHD. HDL cholesterol was positively correlated with physical activity. Insulin secretion was, however, positively associated with physical inactivity, body weight and serum triglycerides. Men with the highest insulin secretion had the lowest glucose tolerance. The study confirms the covariance between HDL cholesterol, insulin secretion, serum triglycerides, body weight and physical activity, but does not support the theory that HDL is a major "negative risk factor" in middle-aged men with preclinical CHD.

Adult↗
PubMed1979

Prevalence and significance of the fourth heart sound (S4) in presumably healthy middle-aged men, with particular relation to latent coronary heart disease.

As part of a cardiovascular survey phonocardiography and auscultation concentrating on the presence/absence of S4 were studied prospectively in 1714 presumably healthy men aged 40--59 yr. The following conclusions were reached: (1) routine phonocardiograms revealed an S4 in greater than 50%; (2) auscultation suggested the presence of S4 in greater than 30%; (3) interobserver variation was approximately 1/6 in the blind interprelation of the phonocardiograms by 2 observers; (4) approximately 3/4 of reported audible S4s were correctly identified; (5) a direct association between S4 and the length of the PQ (PR) interval was found, and (6) a positive association between higher blood pressure and S4, but (7) no association to age, latent coronary heart disease (CHD) nor various CHD risk factors. Thus an S4 is of little diagnostic value in screening of apparently healthy middle-aged subjects, but probably is not a completely innocent finding as suggested recently by some investigators.

Adult↗
PubMed1978

Significance of P wave terminal force in presumably healthy middle-aged men.

In a material comprising 695 males aged 40 to 60 years without cardiovascular disease, the prevalence of abnormal P wave terminal force in V1 (V1Ptf) (less than or equal to - 0.03 mm. second) at rest was 7.1 per cent, whereas the prevalence five minutes after a near-maximal exercise test was 25.4 per cent. Abnormal V1Ptf was associated with a slightly higher systolic and diagstolic blood pressure, maximal rise of systolic blood pressure, and maximal rate-pressure product during the exercise test. The prevalence of abnormal V1Ptf was not significantly higher in another group of 95 individuals who were angiographied because of strong suspicion of latent coronary heart disease (CHD) according to exercise electrocardiogram. An abnormal V1Ptf may be considered as a possibly clinically unimportant anomaly in otherwise healthy middle-aged men. V1Ptf is not suitable as a tool for the diagnosis of latent CHD.

Adult↗
PubMed1978

The effect of smoking on selected coronary heart disease risk factors in middle-aged men.

Associations between smoking and selected factors supposed to promote coronary heart disease (CHD) were studied in 1832 healthy men, 809 of whom were smokers. Triglycerides were 7% higher in smokers; the heaviest smokers had the highest levels. Unfavourable changes were not seen in the other parameters in smokers. There was no trend indicating an influence of smoking on total and HDL cholesterol in the individuals who had abstained from smoking for a few hours just before the examination. Body mass index and weight, blood pressure and resting heart rate were lower in smokers, whereas heart volume, glucose tolerance, thyroid function and ECG findings did not differ significantly in smokers and non-smokers. The present study indicates that smoking promotes the development of CHD independently of the commonly accepted CHD risk factors.

Adult↗
PubMed1978

ECG aberrations, latent coronary heart disease and cardiopulmonary fitness in various age groups of Norwegian cross-country skiers.

To assess the prevalence of possible, latent coronary heart disease (CHD) among physically active men, 149 elite cross-country skiers in three age groups (26-33, 43-50 and 58-64 years) were invited for an examination which included clinical examination, Vitalogram, resting ECG, and a near maximal bicycle test. Of the invited men, 122 participated, i.e. 81.8%. The following findings were made: Normal clinical findings in all except 2, low resting heart rate, lung function parameters of about normal mean; voltage signs of left ventricular hypertrophy in resting ECG in 61/122, incomplete right bundle branch block in 14/122, codable Q waves (Minnesota Code, MC) in 5/87 from the highest age groups, ischaemic exercise ECG changes of MC 4.1 or 4.2 types in 11/87 vs. 1/35 in the two oldest vs. the youngest age group. Physical performance was very high in all age groups, but regular training did not seem to inhibit the normal age-dependent decline in physical performance. The resting and exercise ECG data in the two oldest age groups did not differ favourably from similar data obtained in sedentary men of the same age from approximately the same geophraphic area. Thus, it is possible that regular strenuous exercise and training may not protect against the development of CHD. The implications of such a view are briefly discussed.

Adult↗
PubMed1978

Smoking, lung function, physical performance and latent coronary heart disease in presumably healthy middle-aged men.

During a cardiovascular survey comprising 2014 presumably healthy men aged 40-59 years, latent (previously undetected) coronary heart disease (CHD), lung function and physical performance were related to differences in smoking habits. The survey examination classified 1 832 individuals as "normals" (without clinical signs/symptoms of CHD). Among the others, a strong supicion of CHD was found in 115, of whom 105 had diagnostic coronary angiography. No angiography was performed in another 35 individuals with slight, albeit typical angina pectoris. The remaining 42 men were excluded from this presentation for various reasons. The following findings were obtained: 1) in the 69 men with positive coronary angiography, the extent of coronary atheromatosis was positively related to the number of cigarettes smoked. 2) The smoking habits of the 35 individuals with slight angina pectoris but no angiography did not differ from those of the "normals". 3) Physical performance during a near maximal bicycle exercise test and lung function according to spirometry were strongly and negatively related to smoking (in "normals"). 4) Previous smokers and never-smokers among "normals" had almost identical lung function and physical performance.

Adult↗
PubMed1977

Chronic effect of smoking on platelet count and "platelet adhesiveness" in presumably healthy middle-aged men.

In 386 men aged 40-49 years the number of platelets was related to differences in smoking habits. "Platelet adhesiveness" (retention) was estimated by a glass bead filter method in 376 of these men. The estimation of "adhesiveness" was performed in native blood without anticoagulants at least 12 hr after the last cigarette smoked. A small but statistically highly significant increase in platelet count, in number of "adhesive platelets" and percentage of "adhesive platelets" was found in smokers as compared with non-smokers, the highest values being found in the heaviest smokers and vice versa. Such smoking-related changes in platelet count and reactiveness might unfavourably influence the tendency towards coronary thrombosis, and might in part explain the deleterious effects of smoking on coronary heart disease morbidity and mortality.

Adult↗