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Biomedical subjects

J Erikssen

Publications and source records attributed to J Erikssen.

At least 109 records · Page 6Linked to original sources
PubMed1984

Five-year follow-up of ECG aberrations, latent coronary heart disease and cardiopulmonary fitness in various age groups of Norwegian cross-country skiers.

A cross-sectional sample of 122 middle-aged and elderly long-time active, well-trained male cross-country skiers were studied in 1976 to assess the prevalence of possible latent coronary heart disease (CHD). One hundred and seventeen skiers were reexamined five years later to assess the prognostic significance of a number of ECG aberrations encountered in 1976, and to assess the CHD incidence among athletes. One had died and four did not participate in the restudy, but none of these five men had had cardiac disease. The findings at the time of the two surveys were remarkably similar. All had excellent physical performance and a stable life habit pattern. Only three had given up regular training in the observation period. There was a very high prevalence of sinus bradycardia, first degree AV blocks, left ventricular hypertrophy (LVH) and incomplete right bundle branch block. Pathologic exercise ECGs were found on both occasions. Of 23 men with "pathologic" exercise ECG, 21 had LVH. Five had codable Q waves according to the Minnesota code, but none had symptoms of CHD. Two developed angina pectoris during the follow-up and none had had myocardial infarction. It is concluded that the large number of ECG aberrations found in middle-aged and elderly athletes are mainly related to physiological adaptation to training and that training seems to protect against CHD.

Adult↗
PubMed1984

Heart volumes in healthy middle-aged men. A seven-year prospective investigation.

The heart volume was followed over a 7-year period in 819 healthy men aged 40 to 59 years. The subjects were selected on the basis of unremarkable clinical findings and technically satisfactory films on two occasions 7 years apart. On both occasions the mean heart volume in the upright position was 390 ml/m2 (96.6% below 500), uninfluenced by age, and moderately larger in subjects with high physical fitness. Inclusion of subjects who were healthy during the baseline examination, but who developed heart disease or other diseases during the follow-up period, would have increased the mean heart volume by 15 ml/m2. Latent coronary heart disease did not influence the heart volume, but intercurrent myocardial infection increased the follow-up volumes significantly.

Age Factors↗
PubMed1983

False suspicion of coronary heart disease: a 7 year follow-up study of 36 apparently healthy middle-aged men.

Latent coronary heart disease was suspected in 115 of 2014 apparently healthy middle-aged men after a baseline cardiovascular survey. One hundred five of these men underwent angiography and 36 were found to have normal coronary arteries (group 1). A 7 year follow-up survey revealed that: (1) three had died of sudden cardiac death, (2) four had received a diagnosis of cardiomyopathy, (3) one had developed aortic dilatation/aortic regurgitation since the baseline survey, (4) they all had a significantly more rapid decline in their physical performance and maximal heart rate levels from the time of the baseline survey to follow-up than did randomly selected normal controls (group 2), and (5) thallium study results were normal in both groups (27 and 26 patients), but technetium ventriculography revealed a subnormal increase in ejection fraction during exercise (less than 5% units) in 14 of 27 group 1 subjects and in 4 of 26 group 2 subjects. Thus, incipient heart disease may be present in subjects in whom coronary angiographic examination has removed a previous suspicion of coronary heart disease.

Adult↗
PubMed1982

PR interval in middle-aged men with overt and latent coronary heart disease compared to PR in angionegative and normal men of similar age.

PR was measured prospectively in 2014 apparently healthy men ranging in age from 40 to 59 years (P subjects), and retrospectively in 652 hospitalized men with a diagnosis of coronary heart disease (CHD) (R subjects). A cardiovascular survey examination suggested CHD in 115 of the 2014 P subjects, coronary angiography of 105 of these confirmed this suspicion in 69. The following observations concerning PR were made: (1) the shortest PR was found in angiopositive P subjects, intermediate PR in 1832 normal P subjects, and PR was longest in 36 angionegative subjects. (2) PR was shortest in angiopositive P subjects with triple-vessel disease, and longest in P subjects with single-vessel disease, (3) PR increased with age, and an inverse association was found between PR and resting heart rate in P-subjects. (4) In 98 of 1832 normal P subjects, all without signs or symptoms of heart disease, PR was greater than or equal to 0.22 s. (5) Prolonged PR was no more frequent among the 652 R subjects than among P subjects, despite significant CHD in 595, and a frequent use of drugs known to delay atrioventricular conduction. It is suggested that advanced stable clinical CHD only rarely gives rise to prolonged PR at rest, and that PR in subjects with latent CHD may have somewhat shorter PR than age counterparts without symptoms or signs of CHD. Conflicting data in the literature are probably related to differences in material and methods.

Adult↗
PubMed1982

Coronary artery disease with and without angina--two different entities?

Coronary heart disease (CHD), previously neither diagnosed nor suspected, was strongly suspected in 115 of 2014 men aged 40-59 years during a cardiovascular survey examination. Sixty-nine of 105 men who underwent diagnostic coronary angiography had pathologic angiograms. Twenty-six of these 69 had angina pectoris (AP) with and without pathologic exercise ECGs and 43 had pathologic exercise ECG as the only indicator of CHD. The extent of coronary artery changes was similar in the two groups. The men without AP were in almost all respects similar to 1832 men labelled as normals. The men with AP differed in several respects from their non-AP angiographic counterparts and from their non-AP angiographic counterparts and from the normals: they had more dyspepsia, a higher stress score, higher serum cholesterol and triglycerides, lower antithrombin III levels in the blood and lower blood platelet retention values. These results indicate that coronary artery disease with and without AP may represent somewhat different pathogenetic entities.

Adult↗
PubMed1982

Comparison of beta-adrenoceptor blockers under maximal exercise (pindolol v metoprolol v atenolol).

1 The time-related, comparative beta-adrenoceptor blocking effect of metoprolol 150 mg twice daily, atenolol 100 mg once daily and pindolol 7.5 mg twice daily on heart rate, blood pressure, work performance, blood lactate, free fatty acids and plasma catecholamines was studied in ten males aged 19--25 years by means of repeated maximal bicycle exercise tests. 2 At steady state several differences in effects were noted among the drugs. These could be explained by differences in beta 1-selectivity, potency of the chosen drug-doses and intrinsic sympathomimetic activity (ISA). 3 This study emphasizes the importance of including strong sympathetic stimuli in any model used for comparing beta-adrenoceptor blockers with and without ISA in order not to underrate the effects of beta-adrenoceptor blockers with ISA. 4 In the chosen doses pindolol was more effective, and atenolol less effective than metoprolol in suppressing heart rate and blood pressure responses to maximal exercise.

Adrenergic beta-Antagonists↗
PubMed1982

Detection of coronary artery disease with gated cardiac blood-pool scintigraphy: comparison of cold pressor test and dynamic exercise.

Forty-six subjects (11 normals with no cardiac disease, 13 persons with a 'false' positive exercise ECG test, and 22 patients with coronary artery disease) were investigated with ECG-gated cardiac blood-pool imaging at rest, during cold pressor stimulation, and during supine bicycle exercise. Changes in left ventricular ejection fraction and intervention induced regional wall motion abnormalities were measured. Cold pressure stimulation did not induce anginal pain in any person, but were generally found more unpleasant than dynamic exercise. Dynamic exercise detected significantly more coronary artery disease patients (20/22, 91%) than did cold stimulation (13/22, 59%) (P less than 0.02). Specificity of dynamic exercise and cold stimulation was not significantly different. It is concluded that cold stimulation is less sensitive than dynamic exercise in the detection of patients with ischaemic heart disease with gated cardiac blood-pool imaging.

Cold Temperature↗
PubMed1982

Platelet function related to the development and presenting symptoms in coronary artery disease. An epidemiological study in apparently healthy men.

Among 2014 apparently healthy men aged 40-59 years platelet function was studied with Hellem's retention method in 488 men. In 55 of these 488 men coronary heart disease (CHD) was strongly suspected and coronary angiography confirmed the diagnosis in 34 of 51 angiographied men. Platelet responsiveness was significantly lower among those who had angina pectoris than among their CHD-suspect counterparts without angina, regardless of coronary angiographic findings. Since angiopositive men without angina and 408 "normals" had similar retention values, it seems as if presenting symptoms, but not the development of CHD are linked to platelet function. During a near maximal bicycle exercise test significantly higher peak exercise blood pressure was found among men with very low retention values than among men with retention values in the middle and upper range. This could not be explained by differences in maximal heart rate or work performance. This indicates that blood pressure regulation during exercise may in part be linked to platelet function related mechanisms.

Adult↗
PubMed1982

Routine radionuclide techniques in evaluation of patients with suspected coronary heart disease.

Myocardial scintigraphy with thallium-201 and electrocardiogram-gated left ventriculography with technetium-99m labelled red blood cells were applied in four groups of subjects: 25 with no signs or symptoms of cardiovascular disease (group 1), 28 with a "false" positive exercise electrocardiogram (group 2), 14 with angina pectoris and normal coronary angiograms (group 3), and 43 with angina pectoris and fixed coronary artery stenoses (group 4). In groups 1 and 4 the radionuclide findings were in accordance with clinical and invasive measurements. In groups 2 and 3 the most important finding was the lack of increase in left ventricular ejection fraction during exercise in about half of these subjects (even a decrease in 25%), indicating subnormal myocardial reserve. The additional finding of pathological myocardial biopsies in four of these patients suggests that asymptomatic ST depression in patients with normal coronary angiograms may in some cases represent an early, preclinical sign of cardiomyopathy.

Angina Pectoris↗
PubMed1982

Latent ischemic heart disease in sea captains.

For 110 apparently healthy Norwegian captains on ocean-going ships a near maximal bicycle exercise test revealed a pathological exercise electrocardiogram for 10.0%, while the corresponding results for a comparable group of Oslo men and a group of Norwegian sea pilots were 4.6 and 11.8%, respectively. The significant difference in prevalence between the captains and Oslo men could not be explained by differences in serum lipids, blood pressure, or a family history of coronary heart disease. The captains were taller and more physically fit than the Oslo men, but they were significantly heavier and had a more rapid age decline in physical performance capacity and a higher prevalence of heavy smokers. Ten of the 11 captains with a pathological exercise electrocardiogram were, or had been, heavy smokers (greater than or equal to 20 cigarettes/d). A high caloric intake in relation to caloric expenditure, heavy smoking, and poorly defined factors such as stress, irregular workhours, and varying climatic conditions are factors to be considered as explanations for these findings. The claim by captains that they have a higher risk than average for developing coronary heart disease was to some extent corroborated in the present study.

Adult↗
PubMed1981

Coronary risk factors and physical fitness in healthy middle-aged men.

In 1832 healthy men aged 40-59 years subjected to a near maximal bicycle exercise test, physical fitness decline with age. Higher levels of physical fitness were in all age groups associated with lower cigarette consumption, blood pressure, serum triglycerides, hemoglobin and with better pulmonary function. Serum cholesterol, however, was independent of changes in physical fitness. In view of the beneficial effect of high physical activity on the well-known coronary risk factors, it is surprising that it has proved so difficult to show a protective effect of increased physical fitness and activity in coronary heart disease and its manifestations.

Adult↗
PubMed1981

Coronary heart disease in Norwegian sea-pilots: part of the occupational hazard?

A near maximal bicycle exercise test revealed a prevalence of positive exercise ECG's of 8/68 among apparently healthy sea-pilots and 93/2014 among apparently healthy men of comparable age in Oslo (P less than 0.01). This difference could not be explained in terms of differences in commonly accepted coronary heart disease risk factors (cholesterol/triglycerides, smoking habits and blood pressure). Reasons for the difference should be sought in the working environment of the pilots as well as in possible unfavourable life habits adapted during leisure time as indicated by a relative increase in body weight and somewhat lower working capacity in pilots than in age matched counterparts from Oslo.

Adult↗
PubMed1981

Effect of timolol on platelet aggregation in coronary heart disease.

The immediate effect of beta-blockers versus placebo in platelet function was studied in ten healthy men one hour after either 40 mg propranolol, 5 mg timolol or placebo was given. Both beta-blockers had similar platelet effects. They increased the ADP-threshold in a platelet aggregation test and reduced the plasma level of beta-thromboglobulin whereas the primary aggregation remained unchanged. Forty-four patients were given timolol 10 mg twice daily or corresponding placebo medication in a secondary prevention trial after a myocardial infarction. At rest and also immediately after a near maximal exercise test the platelet function was similar on timolol and placebo. During exercise a lower ADP-threshold and a higher plasma level of beta-thromboglobulin was observed irrespective of whether the patients received placebo or timolol. Thus, the acute platelet inhibiting effect of timolol observed after a single dose disappeared during chronic timolol treatment. During 24 hours continuous ambulatory ECG monitoring patients on timolol treatment had significantly less arrhythmias than patients on placebo. A general effect on platelets cannot explain this antiarrhythmic effect of timolol during chronic therapy.

Adult↗
PubMed1981

Angiographic and risk factor characteristics of subjects with early onset ischaemic heart disease.

Sixty-six consecutive patients less than 40 years of age with angiographically documented coronary artery disease and coronary heart disease took part in a study aimed at (1) identifying the presence of factors which might explain the premature onset of ischaemic heart disease, and (2) assessing the distribution and severity of the coronary artery lesions. For comparisons we have used a study of risk factors in 1832 men defined as "normals" according to a recent comprehensive examination. The findings show that the typical early onset coronary heart disease case is an overweight, heavily smoking male "blue collar" worker, with high serum levels, a marginally raised blood pressure, and a high prevalence of coronary heart disease among first degree relatives. Coronary angiography showed a preponderance of one vessel disease. In particular, left anterior descending artery lesions were common, which might have contributed to the early manifestation of disease.

Adult↗