Search PubMed⌕ Search

Biomedical subjects

J Eriksen

Publications and source records attributed to J Eriksen.

At least 127 records · Page 7Linked to original sources
PubMed1980

Common variable immunodeficiency and purine nucleotidase and nucleoside phosphorylase deficiency. A case report.

The results of immunological and purine enzyme investigations in an adult male patient with common variable immunodeficiency, recurrent lymph node granuloma and splenomegaly are presented. Serum immunoglobulins were present in trace amounts only and a progressive loss of Ig-bearing peripheral lymphocytes were demonstrated. Furthermore, the mitogenic responses to PHA. ConA and PWM were markedly reduced and the ratio of T.m/T.g cells was decreased. Finally, a combined deficiency of lymphocyte purine 5-nucleoside phosphorylase was demonstrated in the patient.

Adult↗
PubMed1979

Association between HLA-A1,B8 in children with extrinsic asthma and IgA deficiency.

The tissue types, immunoglobulin levels, and the presence of circulating autoantibodies were investigated in 57 children. Fifteen of these children suffered from bronchial asthma and, in addition, had no or very little IgA in their serum and saliva (Group 1 patients). Another fifteen children with asthma but normal immunoglobulin levels in serum and saliva (Group 2 patients), seven patients with selective IgA deficiency but without allergic diseases (Group 3 patients), and twenty healthy children served as controls. Sixty per cent of the Group 1 patients had the phenotype HLA-A1,B8, whereas this tissue type was found only in 27, 14 and 15 per cent, respectively, of the Group 2 and Group 3 patients and the healthy children. Furthermore, high IgM- and IgE levels were observed in most Group 1 patients, and in five of these patients (33 per cent) autoantibodies were present in the serum. In addition, eczema and glomerulonephritis occurred rather frequently in this group of patients. Conversely, normal immunoglobulin levels and absence of circulating autoantibodies were found in the remaining three groups of children. The results emphasize the heterogeneity of the IgA deficiency syndrome, and the question is raised as to whether the tissue type HLA-A1,B8 observed in most Group 1 patients reflects the abnormal immune reactivity of these patients.

Adolescent↗
PubMed1979

Percutaneous cannulation of the dorsalis pedis artery. A prospective study.

Strain-gauge plethysmography was used to determine the systolic arterial pressure in the great toe of 38 patients (aged 23-70 yr) undergoing lung surgery. In eight patients (21%) manual compression of the dorsalis pedis artery reduced the arterial pressure in the great toe to less than 40 mm Hg, and cannulation of the artery was not attempted. In 24 of 30 patients with adequate collateral arterial supply, a Teflon cannula (Venflon 1.20) was inserted percutaneously to the dorsalis pedis artery. Median cannulation time was 160 min. Six patients (25%, 95% confidence limits 10-47%) developed thrombosis of the artery and, in one, unsuccessful cannulation caused thrombosis. In two patients, recanalization of the artery occurred between the 2nd and the 8th day after operation. In four patients, examination 3-5 months after cannulation revealed a persisting decrease in the function of the dorsalis pedis artery. This suggests that the dorsalis pedis artery should not normally be selected for cannulation.

Adult↗
PubMed1979

Relationships between oxygen and carbon dioxide tensions and acid-base balance in arterial blood and in medullary blood from long bones in dogs.

By means of an invasive technique the relations between arterial and medullary gas tensions PO2 and PCO2), and arterial and medullary acid-base balance (pH and standard bicarbonate) were determined in long bones in seven anaesthetized dogs. A semilogarithmic correlation was found between the arterial oxygen tension and the oxygen tension in the medullary blood. Between the arterial carbon dioxide tension and the medullary blood carbon dioxide tension a linear correlation was demonstrated A linear correlation was also found between arterial pH and standard bicarbonate values and the corresponding values obtained from medullary blood. With regard to the parameters investigated no difference was demonstrated between epiphyseal, metaphyseal or diaphyseal medullary blood.

Acid-Base Equilibrium↗
PubMed1979

Observations on long bone medullary pressure in relation to mean arterial blood pressure in the anaesthetized dog.

To study the influence of variations in mean arterial pressures (MAP) on long bone medullary pressures, seven anaesthetized dogs were investigated. The medullary pressures were measured in the epiphyseal, the metaphyseal and the diaphyseal regions and remained rather constant when MAP was above 80 mmHg. Below this level of MAP a statistically significant (P less than 0.01) reduction of the medullary pressures was seen. Comparing the mean medullary pressures obtained with ranges of MAP of 81--100 mmHg (the control medullary pressures) and of 61--80 mmHg, the greatest decline was seen in the epiphyseal and the diaphyseal regions, from 25.2 mmHg to 8.1 mmHg and from 26.7 mmHg to 8.3 mmHg, respectively. The corresponding decrease in the metaphyseal region was from 18.9 mmHg to 10.9 mmHg. The mean values of intraosseous pressure measured by our technique were between 20--30 mmHg and this is in accordance with measurements in normal humans found by other authors.

Animals↗
PubMed1979

Observations on long bone medullary pressures in relation to arterial PO2, PCO2 and pH in the anaesthetized dog.

To investigate the influence of variations in arterial oxygen tensions (PaO2), arterial carbon dioxide tensions (PaCO2), and arterial pH on long bone medullary pressures, seven anaesthetized dogs were investigated. Comparing the control medullary pressures, i.e. the mean medullary pressures obtained at the normal range of PaO2 (75--110 mmHg) with the mean medullary pressures corresponding to the range of PaO2 of less than 75 mmHg, statistically significant (P less than 0.05) decreases were seen in both epiphyseal, metaphyseal and diaphyseal medullary pressures, from 27.6 +/- 5.0 to 15.5 +/- 3.6 mmHg, from 23.5 +/- 2.9 to 13.9 +/- 2.3 mmHg and from 27.7 +/- 3.9 to 18.3 +/- 2.5 mmHg (all mean values +/- s.e. mean), respectively. Hyperoxia, hypocapnia, hypercapnia or metabolic acidosis had no effect on medullary pressures in any of the regions studied.

Animals↗
PubMed1979

Genetic transformation in Streptococcus sanguis. Spontaneous and induced competence of selected strains.

Nine strains of Streptococcus sanguis were examined for competence in genetic transformation with streptomycin resistance (str-r) as marker. Eight strains belonged to serogroup H and one to the newly-described serogroup W. Seven of the strains, one of which was the reference strain NCTC 7868 (strain Challis), were competent with str-r DNA from strain Challis. Strains NCTC 9124 (strain Wicky) and 480 were incompetent. The efficiency of transformation was examined in four different media. Use of Todd Hewitt broth gave frequencies of transformants as high as the more complex media. Addition of serum to the transformation media was not essential for the development of competence. The presence of a competence factor (CF) in the culture filtrate of strain Challis was confirmed. The factor transferred strain Wicky to competence with a great variation in the number of transformants and had no influence on strain 480. On the other hand, this spontaneously incompetent strain became competent after addition of culture filtrate from the competent strain 13b, in contrast to Wicky which now remained incompetent. Thus, it is suggested that several factors are involved in the induction of competence of S. sanguis.

Bacterial Proteins↗
PubMed1978

Postanaesthetic postural stability following thiopental or propanidid anaesthesia.

Using a quantitative Romberg-test performed on a computerized force-plate-system, postural stability was tested in 39 patients before and 3 hours after general anaesthesia with either thiopental (20 patients) or propanidid (19 patients). Sway-tendencies in the sagittal and the transversal direction were recorded. Comparing pre- and postoperative test results, patients anaesthetized with thiopental had a decreased postural stability 3 hours after anaesthesia, indicated by a significantly (P less than 0.05) increased sway-tendency of 22.6% in the sagittal direction. No change occurred in sway-tendency in the transversal direction in this group. In the propanidid group no significant differences were found between pre- and postoperative test results.

Adolescent↗
PubMed1978

More on cross-reactions of Pneumococci and Klebsiella.

Earlier studies are extended to the higher-numbered K-types of Klebsiella, several of which may now be fitted into the previously found groups. Additional correlations between chemical structure and serological specificity are given, not only among the higher K-types, but also for several which were previously uninterpretable because structures were not known at the time. K1, K5, K6, K7 and K56 are shown to form a related group, although the reasons for their cross-reactivities are not always the same.

Antibodies, Bacterial↗
PubMed1977

Postoperative pulmonary function in obese patients after upper abdominal surgery.

The pulmonary course after jejuno-ileal by-pass operation in six massively obese patients (mean weight 130.2 kg) was followed for the first 5 postoperative days by means of arterial blood gas analysis and measurements of forced vital capacity (FVC), forced expired volume in the first second (FEV1.0) and peak expiratory flow rate (PEFR). The patients were extubated in the operating room and were breathing spontaneously in the postoperative period. Pao2 and FVC reached their minimum values in the first 24 postoperative hours (respectively, 74% and 45% of their preoperative values), but were almost restored in 5 days. PEFR had at this time reached 77% of its preoperative value FEV1.0% (FEV1.0%in per cent of FVC) did not change from the pre- to the postoperative period, but remained about 70%.

Adult↗
PubMed1977

Evaluation of impedance cardiography druing anesthesia in extremely obese patients.

In three anesthetized markedly obese patients, non-invasive stroke volumes (the transthoracic electrical impedance method) were compared to simultaneously obtained invasively measured stroke volumes (dye-dilution method). Close correlations were obtained (r = 0.90--0.98) between the two methods, although constant lower impedance stroke volumes were found in these patients when the values usually employed for the electrical resistivity of the blood (zeta) were used for calculation of the impedance stroke volume. No statistically significant difference (P greater than 0.10) between the two methods was found when a zeta of 175 ohm X cm was used for the calculations, or when the percentage changes in stroke volumes were analyzed. The impedance method is safe and reliable; it also permits non-invasive measurements of stroke volume during anesthesia in markedly obese patients.

Anesthesia↗
PubMed1977

Pulmonary function in obese patients scheduled for jejuno-ileostomy.

Preoperative pulmonary parameters were evaluated in 37 extremely obese but otherwise healthy patients. They were on average 100.9% overweight. X-ray of the chest, electrocardiograms, and residual volume, vital capacity, total lung capacity, maximum breathing capacity, forced expired volume in 1 second, and related ratios were all within the normal range. The alveolar-arterial oxygen gradient and the arterial carbon dioxide tension were also within the normal range. The only abnormal finding was a substantially reduced arterial oxygen tension. It is suggested that the measurement of functional residual capacity, closing volume, and the slope of the alveolar plateau (phase III in the single breath nitrogen washout technique) might give more valuable information.

Adult↗